CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = S : Mut = Y145N
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| S | 145 | Y145N | nonsyn | Tac | Aac | 12191 | 12177 | 0.998852 | 21995-21997 | |
| S | 145 | Y145N | nonsyn | TaC | AaT | 12191 | 14 | 0.00114839 | 21995-21997 |
Details of the mutation Y145N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| S | 145 | Y145N | Tac | Aac | 12177 | 12191 | All | 0.002329 |
| S | 145 | Y145N | TaC | AaT | 14 | 12191 | All | 0.000003 |
| S | 145 | Y145N | Tac | Aac | 9994 | 10000 | B.1.621 | 0.88466 |
| S | 145 | Y145N | TaC | AaT | 6 | 10000 | B.1.621 | 0.000531 |
| S | 145 | Y145N | Tac | Aac | 1739 | 1744 | B.1.621.1 | 0.879616 |
| S | 145 | Y145N | TaC | AaT | 5 | 1744 | B.1.621.1 | 0.002529 |
| S | 145 | Y145N | Tac | Aac | 113 | 114 | B.1 | 0.001035 |
| S | 145 | Y145N | TaC | AaT | 1 | 114 | B.1 | 0.000009 |
| S | 145 | Y145N | Tac | Aac | 38 | 38 | B.1.1.7 | 0.000034 |
| S | 145 | Y145N | Tac | Aac | 37 | 37 | B.1.623 | 0.01985 |
| S | 145 | Y145N | Tac | Aac | 27 | 27 | AY.25 | 0.000162 |
| S | 145 | Y145N | Tac | Aac | 19 | 19 | B.1.617.2 | 0.000072 |
| S | 145 | Y145N | Tac | Aac | 16 | 17 | AY.44 | 0.000097 |
| S | 145 | Y145N | TaC | AaT | 1 | 17 | AY.44 | 0.000006 |
| S | 145 | Y145N | Tac | Aac | 14 | 14 | AY.43 | 0.000062 |
| S | 145 | Y145N | Tac | Aac | 11 | 11 | AY.26 | 0.000311 |
| S | 145 | Y145N | Tac | Aac | 10 | 10 | B | 0.001278 |
| S | 145 | Y145N | Tac | Aac | 8 | 8 | AY.20 | 0.000311 |
| S | 145 | Y145N | Tac | Aac | 8 | 8 | B.1.1 | 0.000145 |
| S | 145 | Y145N | Tac | Aac | 8 | 8 | B.1.177.73 | 0.00453 |
| S | 145 | Y145N | Tac | Aac | 8 | 8 | B.1.351 | 0.000238 |
| S | 145 | Y145N | Tac | Aac | 6 | 6 | AY.103 | 0.000037 |
| S | 145 | Y145N | Tac | Aac | 5 | 5 | AY.102 | 0.000133 |
| S | 145 | Y145N | Tac | Aac | 5 | 5 | P.1 | 0.000079 |
| S | 145 | Y145N | Tac | Aac | 4 | 4 | AY.117 | 0.000338 |
| S | 145 | Y145N | Tac | Aac | 4 | 4 | AY.3 | 0.00004 |
| S | 145 | Y145N | Tac | Aac | 3 | 4 | AY.4 | 0.000005 |
| S | 145 | Y145N | TaC | AaT | 1 | 4 | AY.4 | 0.000002 |
| S | 145 | Y145N | Tac | Aac | 4 | 4 | AY.92 | 0.001149 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | A | 0.001161 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | A.2.5 | 0.001497 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | AY.100 | 0.000138 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | AY.110 | 0.000338 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | AY.39 | 0.000074 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | AY.4.2.1 | 0.000447 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | AY.42 | 0.000121 |
| S | 145 | Y145N | Tac | Aac | 3 | 3 | B.1.429 | 0.000071 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | A.2.5.1 | 0.009615 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.119 | 0.000071 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.23 | 0.000139 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.29 | 0.000032 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.35 | 0.000466 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.46 | 0.000208 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.52 | 0.001629 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.67 | 0.000929 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.75 | 0.000112 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | AY.75.1 | 0.000361 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | B.1.157 | 0.00597 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | B.1.533 | 0.019231 |
| S | 145 | Y145N | Tac | Aac | 2 | 2 | P.1.12 | 0.000968 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | A.23.1 | 0.000704 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.1 | 0.000396 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.101 | 0.00049 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.113 | 0.000142 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.12 | 0.000316 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.27 | 0.000065 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.34.1 | 0.00051 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.36 | 0.000148 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.4.3 | 0.000842 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.45 | 0.000122 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.46.6 | 0.000072 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.47 | 0.000031 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.48 | 0.000465 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.5.3 | 0.000337 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.53 | 0.000288 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.54 | 0.000095 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.74 | 0.000116 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.9 | 0.000068 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | AY.99.2 | 0.000092 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.161 | 0.003534 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.236 | 0.006897 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.263 | 0.001558 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.28 | 0.000311 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.306 | 0.000438 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.348 | 0.000796 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.523 | 0.001563 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.1.99 | 0.02381 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.167 | 0.007812 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.177 | 0.000013 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.2 | 0.000009 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.221 | 0.000071 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.326 | 0.007576 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.36.27 | 0.000763 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.367 | 0.000792 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.380 | 0.006623 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.399 | 0.001934 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.427 | 0.00005 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.459 | 0.004082 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.497 | 0.000315 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.526 | 0.000024 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.630 | 0.005236 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.1.638 | 0.052632 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.4 | 0.002208 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | B.55 | 0.00295 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | C.37 | 0.000116 |
| S | 145 | Y145N | Tac | Aac | 1 | 1 | P.1.14 | 0.000048 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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