CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = S : Mut = V367L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
S	367	V367L		nonsyn	Gtc	Ctc	3246	3241	0.99846	22661-22663
S	367	V367L		nonsyn	GtC	CtA	3246	4	0.00123229	22661-22663
S	367	V367L		nonsyn	GtC	CtT	3246	1	0.000308071	22661-22663

Details of the mutation V367L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
S	367	V367L	Gtc	Ctc	3241	3246	All	0.00062
S	367	V367L	GtC	CtA	4	3246	All	0.000001
S	367	V367L	GtC	CtT	1	3246	All	0
S	367	V367L	Gtc	Ctc	1760	1761	AY.37	0.556258
S	367	V367L	GtC	CtT	1	1761	AY.37	0.000316
S	367	V367L	Gtc	Ctc	884	884	B.1.1.7	0.000791
S	367	V367L	Gtc	Ctc	115	115	B.1.617.2	0.000433
S	367	V367L	Gtc	Ctc	81	81	AY.4	0.000126
S	367	V367L	Gtc	Ctc	49	49	B.1.2	0.000431
S	367	V367L	Gtc	Ctc	34	34	AY.44	0.000207
S	367	V367L	Gtc	Ctc	32	32	AY.43	0.000142
S	367	V367L	Gtc	Ctc	23	23	AY.3	0.000229
S	367	V367L	Gtc	Ctc	22	22	AY.25	0.000132
S	367	V367L	Gtc	Ctc	13	13	AY.20	0.000505
S	367	V367L	Gtc	Ctc	13	13	B.1.177	0.000171
S	367	V367L	Gtc	Ctc	12	12	AY.29	0.000189
S	367	V367L	Gtc	Ctc	10	10	AY.4.2	0.000217
S	367	V367L	Gtc	Ctc	10	10	AY.47	0.000311
S	367	V367L	Gtc	Ctc	10	10	P.1.14	0.000478
S	367	V367L	Gtc	Ctc	10	10	Q.8	0.001649
S	367	V367L	Gtc	Ctc	9	9	AY.103	0.000056
S	367	V367L	Gtc	Ctc	8	8	AY.13	0.001288
S	367	V367L	Gtc	Ctc	8	8	P.1	0.000126
S	367	V367L	Gtc	Ctc	7	7	C.37	0.000812
S	367	V367L	Gtc	Ctc	5	6	B.1.1	0.000091
S	367	V367L	GtC	CtA	1	6	B.1.1	0.000018
S	367	V367L	Gtc	Ctc	6	6	B.1.429	0.000141
S	367	V367L	Gtc	Ctc	5	5	AY.23	0.000349
S	367	V367L	Gtc	Ctc	5	5	AY.46	0.00052
S	367	V367L	Gtc	Ctc	5	5	AY.65	0.002665
S	367	V367L	Gtc	Ctc	5	5	AY.75	0.00028
S	367	V367L	Gtc	Ctc	5	5	Q.3	0.000725
S	367	V367L	Gtc	Ctc	4	4	AY.16	0.001519
S	367	V367L	Gtc	Ctc	3	4	B.1	0.000027
S	367	V367L	GtC	CtA	1	4	B.1	0.000009
S	367	V367L	Gtc	Ctc	4	4	B.1.36	0.000584
S	367	V367L	Gtc	Ctc	3	3	AY.102	0.00008
S	367	V367L	Gtc	Ctc	3	3	AY.39	0.000074
S	367	V367L	Gtc	Ctc	3	3	AY.5	0.000062
S	367	V367L	Gtc	Ctc	3	3	AY.98	0.000237
S	367	V367L	Gtc	Ctc	3	3	B.1.571	0.029126
S	367	V367L	Gtc	Ctc	2	2	A.2.5	0.000998
S	367	V367L	Gtc	Ctc	2	2	AY.26	0.000057
S	367	V367L	Gtc	Ctc	2	2	AY.33	0.000134
S	367	V367L	Gtc	Ctc	2	2	AY.39.1	0.000079
S	367	V367L	Gtc	Ctc	2	2	AY.45	0.000243
S	367	V367L	Gtc	Ctc	2	2	AY.54	0.000191
S	367	V367L	Gtc	Ctc	2	2	AY.60	0.001876
S	367	V367L	Gtc	Ctc	2	2	AY.9.2	0.000073
S	367	V367L	Gtc	Ctc	2	2	B.1.1.216	0.001781
S	367	V367L	Gtc	Ctc	2	2	B.1.1.294	0.002532
S	367	V367L	Gtc	Ctc	2	2	B.1.1.33	0.000842
S	367	V367L	Gtc	Ctc	2	2	C.38	0.016129
S	367	V367L	Gtc	Ctc	1	2	P.2	0.000187
S	367	V367L	GtC	CtA	1	2	P.2	0.000187
S	367	V367L	GtC	CtA	1	1	A	0.000387
S	367	V367L	Gtc	Ctc	1	1	AY.100	0.000046
S	367	V367L	Gtc	Ctc	1	1	AY.110	0.000113
S	367	V367L	Gtc	Ctc	1	1	AY.111	0.000183
S	367	V367L	Gtc	Ctc	1	1	AY.119	0.000035
S	367	V367L	Gtc	Ctc	1	1	AY.120	0.000037
S	367	V367L	Gtc	Ctc	1	1	AY.14	0.000088
S	367	V367L	Gtc	Ctc	1	1	AY.36	0.000148
S	367	V367L	Gtc	Ctc	1	1	AY.4.5	0.000107
S	367	V367L	Gtc	Ctc	1	1	AY.46.6	0.000072
S	367	V367L	Gtc	Ctc	1	1	AY.61	0.000105
S	367	V367L	Gtc	Ctc	1	1	AY.64	0.000595
S	367	V367L	Gtc	Ctc	1	1	AY.7	0.000196
S	367	V367L	Gtc	Ctc	1	1	AY.71	0.000475
S	367	V367L	Gtc	Ctc	1	1	AY.73	0.000665
S	367	V367L	Gtc	Ctc	1	1	AY.74	0.000116
S	367	V367L	Gtc	Ctc	1	1	AY.75.1	0.00018
S	367	V367L	Gtc	Ctc	1	1	AY.9.1	0.000084
S	367	V367L	Gtc	Ctc	1	1	AY.92	0.000287
S	367	V367L	Gtc	Ctc	1	1	AY.98.1	0.000048
S	367	V367L	Gtc	Ctc	1	1	AY.99.2	0.000092
S	367	V367L	Gtc	Ctc	1	1	B	0.000128
S	367	V367L	Gtc	Ctc	1	1	B.1.1.222	0.000204
S	367	V367L	Gtc	Ctc	1	1	B.1.1.28	0.000311
S	367	V367L	Gtc	Ctc	1	1	B.1.1.284	0.000107
S	367	V367L	Gtc	Ctc	1	1	B.1.1.417	0.002703
S	367	V367L	Gtc	Ctc	1	1	B.1.1.50	0.000679
S	367	V367L	Gtc	Ctc	1	1	B.1.169	0.014925
S	367	V367L	Gtc	Ctc	1	1	B.1.177.80	0.001912
S	367	V367L	Gtc	Ctc	1	1	B.1.243	0.00007
S	367	V367L	Gtc	Ctc	1	1	B.1.258.17	0.000104
S	367	V367L	Gtc	Ctc	1	1	B.1.258.7	0.001912
S	367	V367L	Gtc	Ctc	1	1	B.1.36.29	0.000517
S	367	V367L	Gtc	Ctc	1	1	B.1.389	0.001002
S	367	V367L	Gtc	Ctc	1	1	B.1.438.1	0.000107
S	367	V367L	Gtc	Ctc	1	1	B.1.456	0.003268
S	367	V367L	Gtc	Ctc	1	1	B.1.466.2	0.000391
S	367	V367L	Gtc	Ctc	1	1	B.1.547	0.02439
S	367	V367L	Gtc	Ctc	1	1	B.1.596	0.000087
S	367	V367L	Gtc	Ctc	1	1	B.1.630	0.005236
S	367	V367L	Gtc	Ctc	1	1	L.1	0.001905
S	367	V367L	Gtc	Ctc	1	1	P.1.12	0.000484
S	367	V367L	Gtc	Ctc	1	1	P.7	0.004367
S	367	V367L	Gtc	Ctc	1	1	Q.1	0.000126
S	367	V367L	Gtc	Ctc	1	1	R.1	0.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.