CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = S : Mut = I410T

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
S	410	I410T		nonsyn	aTc	aCc	35	28	0.8	22790-22792
S	410	I410T		nonsyn	aTC	aCA	35	5	0.142857	22790-22792
S	410	I410T		nonsyn	aTC	aCT	35	1	0.0285714	22790-22792
S	410	I410T		nonsyn	aTC	aCG	35	1	0.0285714	22790-22792

Details of the mutation I410T within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
S	410	I410T	aTc	aCc	28	35	All	0.000005
S	410	I410T	aTC	aCA	5	35	All	0.000001
S	410	I410T	aTC	aCG	1	35	All	0
S	410	I410T	aTC	aCT	1	35	All	0
S	410	I410T	aTc	aCc	8	8	B.1.617.2	0.00003
S	410	I410T	aTc	aCc	6	7	B.1.1.7	0.000005
S	410	I410T	aTC	aCA	1	7	B.1.1.7	0.000001
S	410	I410T	aTc	aCc	1	3	AY.44	0.000006
S	410	I410T	aTC	aCG	1	3	AY.44	0.000006
S	410	I410T	aTC	aCT	1	3	AY.44	0.000006
S	410	I410T	aTC	aCA	2	2		0.111111
S	410	I410T	aTc	aCc	2	2	AY.43	0.000009
S	410	I410T	aTc	aCc	2	2	B.1.1	0.000036
S	410	I410T	aTc	aCc	1	2	B.1.1.326	0.001761
S	410	I410T	aTC	aCA	1	2	B.1.1.326	0.001761
S	410	I410T	aTc	aCc	2	2	B.1.525	0.000226
S	410	I410T	aTc	aCc	2	2	B.1.596	0.000174
S	410	I410T	aTc	aCc	1	1	AY.103	0.000006
S	410	I410T	aTc	aCc	1	1	B.1.1.519	0.00004
S	410	I410T	aTc	aCc	1	1	B.1.2	0.000009
S	410	I410T	aTC	aCA	1	1	B.1.258.17	0.000104
S	410	I410T	aTc	aCc	1	1	B.1.351	0.00003

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.