CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = S : Mut = E180V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
S	180	E180V		nonsyn	gAa	gTa	3665	3662	0.999181	22100-22102
S	180	E180V		nonsyn	gAA	gTT	3665	2	0.000545703	22100-22102
S	180	E180V		nonsyn	gAA	gTC	3665	1	0.000272851	22100-22102

Details of the mutation E180V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
S	180	E180V	gAa	gTa	3662	3665	All	0.0007
S	180	E180V	gAA	gTT	2	3665	All	0
S	180	E180V	gAA	gTC	1	3665	All	0
S	180	E180V	gAa	gTa	2285	2285	AY.4	0.003556
S	180	E180V	gAa	gTa	1073	1073	B.1.234	0.141575
S	180	E180V	gAa	gTa	58	58	B.1.617.2	0.000218
S	180	E180V	gAa	gTa	55	55	B.1.2	0.000484
S	180	E180V	gAa	gTa	33	34	B.1	0.000302
S	180	E180V	gAA	gTT	1	34	B.1	0.000009
S	180	E180V	gAa	gTa	26	26	B.1.1	0.000472
S	180	E180V	gAa	gTa	24	24	B.1.287	0.727273
S	180	E180V	gAa	gTa	12	12	AY.54	0.001144
S	180	E180V	gAa	gTa	12	12	B.1.596	0.001046
S	180	E180V	gAa	gTa	6	6	AY.43	0.000027
S	180	E180V	gAa	gTa	6	6	AY.44	0.000037
S	180	E180V	gAa	gTa	6	6	AY.64	0.003571
S	180	E180V	gAa	gTa	6	6	B.1.1.7	0.000005
S	180	E180V	gAa	gTa	5	5	B.1.177	0.000066
S	180	E180V	gAa	gTa	4	4	AY.39	0.000099
S	180	E180V	gAa	gTa	4	4	B.1.177.21	0.000306
S	180	E180V	gAa	gTa	3	3	AY.102	0.00008
S	180	E180V	gAa	gTa	3	3	AY.119	0.000106
S	180	E180V	gAa	gTa	3	3	AY.88	0.002653
S	180	E180V	gAa	gTa	3	3	B.1.1.220	0.005576
S	180	E180V	gAA	gTT	1	2		0.055556
S	180	E180V	gAa	gTa	1	2		0.055556
S	180	E180V	gAa	gTa	2	2	AY.103	0.000012
S	180	E180V	gAa	gTa	2	2	AY.11	0.002677
S	180	E180V	gAa	gTa	2	2	AY.29	0.000032
S	180	E180V	gAa	gTa	2	2	AY.3	0.00002
S	180	E180V	gAa	gTa	2	2	B.1.240	0.000431
S	180	E180V	gAa	gTa	2	2	B.1.580	0.00813
S	180	E180V	gAa	gTa	1	2	P.1.15	0.000232
S	180	E180V	gAA	gTC	1	2	P.1.15	0.000232
S	180	E180V	gAa	gTa	1	1	AY.14	0.000088
S	180	E180V	gAa	gTa	1	1	AY.23	0.00007
S	180	E180V	gAa	gTa	1	1	AY.25	0.000006
S	180	E180V	gAa	gTa	1	1	AY.39.1	0.00004
S	180	E180V	gAa	gTa	1	1	AY.42	0.00004
S	180	E180V	gAa	gTa	1	1	AY.47	0.000031
S	180	E180V	gAa	gTa	1	1	AY.53	0.000288
S	180	E180V	gAa	gTa	1	1	AY.69	0.000187
S	180	E180V	gAa	gTa	1	1	AY.74	0.000116
S	180	E180V	gAa	gTa	1	1	AY.92	0.000287
S	180	E180V	gAa	gTa	1	1	B.1.1.519	0.00004
S	180	E180V	gAa	gTa	1	1	B.1.1.521	0.005348
S	180	E180V	gAa	gTa	1	1	B.1.177.81	0.000189
S	180	E180V	gAa	gTa	1	1	B.1.243	0.00007
S	180	E180V	gAa	gTa	1	1	B.1.311	0.000275
S	180	E180V	gAa	gTa	1	1	B.1.429	0.000024
S	180	E180V	gAa	gTa	1	1	B.1.437	0.020833
S	180	E180V	gAa	gTa	1	1	B.1.524	0.001406
S	180	E180V	gAa	gTa	1	1	D.2	0.000075
S	180	E180V	gAa	gTa	1	1	P.1	0.000016
S	180	E180V	gAa	gTa	1	1	W.4	0.001351

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.