CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = S : CodonNum = 145

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
S	145	Y145H		nonsyn	Tac	Cac	54598	54591	0.999872	21995-21997
S	145	Y145H		nonsyn	TaC	CaT	54598	7	0.00012821	21995-21997
S	145	Y145N		nonsyn	Tac	Aac	12191	12177	0.998852	21995-21997
S	145	Y145N		nonsyn	TaC	AaT	12191	14	0.00114839	21995-21997
S	145	Y145Y		syn	taC	taT	3147	3147	1	21995-21997
S	145	Y145del		del	TAC	---	3074	3074	1	21995-21997
S	145	Y145D		nonsyn	Tac	Gac	825	809	0.980606	21995-21997
S	145	Y145D		nonsyn	TaC	GaT	825	16	0.0193939	21995-21997
S	145	Y145S		nonsyn	tAC	tCT	100	64	0.64	21995-21997
S	145	Y145S		nonsyn	tAc	tCc	100	35	0.35	21995-21997
S	145	Y145S		nonsyn	tAC	tCA	100	1	0.01	21995-21997
S	145	Y145C		nonsyn	tAC	tGT	77	41	0.532468	21995-21997
S	145	Y145C		nonsyn	tAc	tGc	77	36	0.467532	21995-21997
S	145	Y145del1		del	Tac	-ac	43	22	0.511628	21995-21997
S	145	Y145del1		del	taC	ta-	43	7	0.162791	21995-21997
S	145	Y145del1		del	TAc	-Nc	43	6	0.139535	21995-21997
S	145	Y145del1		del	TAC	CG-	43	3	0.0697674	21995-21997
S	145	Y145del1		del	tAc	t-c	43	3	0.0697674	21995-21997
S	145	Y145del1		del	tAC	t-N	43	1	0.0232558	21995-21997
S	145	Y145del1		del	TAC	-NN	43	1	0.0232558	21995-21997
S	145	Y145del2		del	TAC	--A	30	20	0.666667	21995-21997
S	145	Y145del2		del	TAc	--c	30	7	0.233333	21995-21997
S	145	Y145del2		del	tAC	t--	30	2	0.0666667	21995-21997
S	145	Y145del2		del	TAC	C--	30	1	0.0333333	21995-21997
S	145	Y145F		nonsyn	tAc	tTc	18	18	1	21995-21997
S	145	Y145T		nonsyn	TAc	ACc	16	9	0.5625	21995-21997
S	145	Y145T		nonsyn	TAC	ACT	16	7	0.4375	21995-21997
S	145	Y145L		nonsyn	tAC	tTA	13	12	0.923077	21995-21997
S	145	Y145X		nonsyn	taC	taA	13	10	0.769231	21995-21997
S	145	Y145X		nonsyn	taC	taG	13	3	0.230769	21995-21997
S	145	Y145L		nonsyn	TAc	CTc	13	1	0.0769231	21995-21997
S	145	Y145K		nonsyn	TaC	AaA	5	5	1	21995-21997
S	145	Y145P		nonsyn	TAc	CCc	4	2	0.5	21995-21997
S	145	Y145P		nonsyn	TAC	CCT	4	2	0.5	21995-21997
S	145	Y145I		nonsyn	TAC	ATT	2	1	0.5	21995-21997
S	145	Y145I		nonsyn	TAc	ATc	2	1	0.5	21995-21997
S	145	Y145Q		nonsyn	TaC	CaG	2	1	0.5	21995-21997
S	145	Y145Q		nonsyn	TaC	CaA	2	1	0.5	21995-21997
S	145	Y145G		nonsyn	TAc	GGc	1	1	1	21995-21997
S	145	Y145E		nonsyn	TaC	GaA	1	1	1	21995-21997
S	145	Y145V		nonsyn	TAc	GTc	1	1	1	21995-21997
S	145	Y145A		nonsyn	TAc	GCc	1	1	1	21995-21997

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
S	145	Y145H	Tac	Cac	54591	54598	All	0.010441
S	145	Y145H	TaC	CaT	7	54598	All	0.000001
S	145	Y145H	Tac	Cac	45654	45656	AY.4.2	0.990175
S	145	Y145H	TaC	CaT	2	45656	AY.4.2	0.000043
S	145	Y145N	Tac	Aac	12177	12191	All	0.002329
S	145	Y145N	TaC	AaT	14	12191	All	0.000003
S	145	Y145N	Tac	Aac	9994	10000	B.1.621	0.88466
S	145	Y145N	TaC	AaT	6	10000	B.1.621	0.000531
S	145	Y145H	Tac	Cac	5610	5614	AY.4.2.1	0.835816
S	145	Y145H	TaC	CaT	4	5614	AY.4.2.1	0.000596
S	145	Y145Y	taC	taT	3147	3147	All	0.000602
S	145	Y145del	TAC	---	3074	3074	All	0.000588
S	145	Y145del	TAC	---	2094	2094	B.1.1.7	0.001875
S	145	Y145N	Tac	Aac	1739	1744	B.1.621.1	0.879616
S	145	Y145N	TaC	AaT	5	1744	B.1.621.1	0.002529
S	145	Y145H	Tac	Cac	1115	1115	AY.4	0.001735
S	145	Y145D	Tac	Gac	809	825	All	0.000155
S	145	Y145D	TaC	GaT	16	825	All	0.000003
S	145	Y145H	Tac	Cac	804	804	B.1.617.2	0.003027
S	145	Y145H	Tac	Cac	787	787	B.1.1.7	0.000705
S	145	Y145Y	taC	taT	557	557	AY.4	0.000867
S	145	Y145D	Tac	Gac	229	229	AY.4	0.000356
S	145	Y145Y	taC	taT	209	209	AY.44	0.001272
S	145	Y145del	TAC	---	201	201	B.1.618	0.810484
S	145	Y145del	TAC	---	189	189	B.1.637	0.013811
S	145	Y145Y	taC	taT	171	171	B.1.617.2	0.000644
S	145	Y145Y	taC	taT	167	167	P.1	0.002631
S	145	Y145Y	taC	taT	125	125	AY.39	0.003089
S	145	Y145Y	taC	taT	120	120	AY.43	0.000532
S	145	Y145N	Tac	Aac	113	114	B.1	0.001035
S	145	Y145N	TaC	AaT	1	114	B.1	0.000009
S	145	Y145Y	taC	taT	112	112	B.1.2	0.000986
S	145	Y145D	Tac	Gac	90	104	B.1.1.7	0.000081
S	145	Y145D	TaC	GaT	14	104	B.1.1.7	0.000013
S	145	Y145S	tAC	tCT	64	100	All	0.000012
S	145	Y145S	tAc	tCc	35	100	All	0.000007
S	145	Y145S	tAC	tCA	1	100	All	0
S	145	Y145del	TAC	---	93	93	AY.4	0.000145
S	145	Y145Y	taC	taT	83	83	AY.25	0.000499
S	145	Y145Y	taC	taT	82	82	AY.3	0.000816
S	145	Y145Y	taC	taT	81	81	AY.99.2	0.007465
S	145	Y145Y	taC	taT	79	79	B.1.568	0.087778
S	145	Y145C	tAC	tGT	41	77	All	0.000008
S	145	Y145C	tAc	tGc	36	77	All	0.000007
S	145	Y145Y	taC	taT	77	77	B.1.177	0.001014
S	145	Y145S	tAC	tCT	58	77	B.1.621	0.005134
S	145	Y145S	tAc	tCc	18	77	B.1.621	0.001593
S	145	Y145S	tAC	tCA	1	77	B.1.621	0.000089
S	145	Y145Y	taC	taT	70	70	B.1.177.21	0.005353
S	145	Y145Y	taC	taT	68	68	AY.103	0.000422
S	145	Y145Y	taC	taT	60	60	B.1	0.00055
S	145	Y145D	Tac	Gac	56	56	B.1	0.000513
S	145	Y145H	Tac	Cac	48	48	AY.33	0.003205
S	145	Y145del	TAC	---	46	46	AY.43	0.000204
S	145	Y145D	Tac	Gac	46	46	B.1.177	0.000606
S	145	Y145del1	Tac	-ac	22	43	All	0.000004
S	145	Y145del1	taC	ta-	7	43	All	0.000001
S	145	Y145del1	TAc	-Nc	6	43	All	0.000001
S	145	Y145del1	TAC	CG-	3	43	All	0.000001
S	145	Y145del1	tAc	t-c	3	43	All	0.000001
S	145	Y145del1	tAC	t-N	1	43	All	0
S	145	Y145del1	TAC	-NN	1	43	All	0
S	145	Y145H	Tac	Cac	42	42	B.1.314	0.315789
S	145	Y145Y	taC	taT	42	42	B.1.526	0.000987
S	145	Y145Y	taC	taT	41	41	AY.120	0.001524
S	145	Y145H	Tac	Cac	40	40	AY.43	0.000177
S	145	Y145N	Tac	Aac	38	38	B.1.1.7	0.000034
S	145	Y145Y	taC	taT	37	37	AY.100	0.001702
S	145	Y145Y	taC	taT	37	37	AY.5	0.000764
S	145	Y145Y	taC	taT	37	37	B.1.497	0.011646
S	145	Y145N	Tac	Aac	37	37	B.1.623	0.01985
S	145	Y145H	Tac	Cac	35	35	AY.102	0.000928
S	145	Y145Y	taC	taT	35	35	AY.102	0.000928
S	145	Y145Y	taC	taT	34	34	AY.26	0.000963
S	145	Y145Y	taC	taT	33	33	B.1.160.30	0.098214
S	145	Y145H	Tac	Cac	33	33	B.1.258	0.002196
S	145	Y145del	TAC	---	32	32	Q.8	0.005277
S	145	Y145Y	taC	taT	31	31	B.1.561	0.012306
S	145	Y145del2	TAC	--A	20	30	All	0.000004
S	145	Y145del2	TAc	--c	7	30	All	0.000001
S	145	Y145del2	tAC	t--	2	30	All	0
S	145	Y145del2	TAC	C--	1	30	All	0
S	145	Y145Y	taC	taT	30	30	B.1.1	0.000544
S	145	Y145H	Tac	Cac	28	28	AY.3	0.000278
S	145	Y145H	Tac	Cac	28	28	AY.39	0.000692
S	145	Y145N	Tac	Aac	27	27	AY.25	0.000162
S	145	Y145H	Tac	Cac	27	27	AY.44	0.000164
S	145	Y145D	Tac	Gac	26	26	AY.26	0.000736
S	145	Y145Y	taC	taT	26	26	B.1.1.44	0.062651
S	145	Y145Y	taC	taT	25	25	B.1.160	0.00078
S	145	Y145del2	TAC	--A	19	24	B.1.1.7	0.000017
S	145	Y145del2	TAc	--c	4	24	B.1.1.7	0.000004
S	145	Y145del2	TAC	C--	1	24	B.1.1.7	0.000001
S	145	Y145del	TAC	---	23	23	AY.25	0.000138
S	145	Y145del	TAC	---	23	23	B.1	0.000211
S	145	Y145H	Tac	Cac	23	23	B.1.2	0.000203
S	145	Y145Y	taC	taT	23	23	B.1.243	0.0016
S	145	Y145H	Tac	Cac	22	22	AY.25	0.000132
S	145	Y145Y	taC	taT	22	22	AY.42	0.000885
S	145	Y145Y	taC	taT	22	22	B.1.466.2	0.008607
S	145	Y145H	Tac	Cac	21	21	AY.121	0.002842
S	145	Y145del	TAC	---	20	20	B.1.2	0.000176
S	145	Y145C	tAc	tGc	20	20	C.39	0.377358
S	145	Y145D	Tac	Gac	19	20	P.1	0.000299
S	145	Y145D	TaC	GaT	1	20	P.1	0.000016
S	145	Y145Y	taC	taT	19	19	B.1.429	0.000447
S	145	Y145del	TAC	---	19	19	B.1.526	0.000447
S	145	Y145N	Tac	Aac	19	19	B.1.617.2	0.000072
S	145	Y145D	Tac	Gac	19	19	P.1.14	0.000908
S	145	Y145F	tAc	tTc	18	18	All	0.000003
S	145	Y145D	Tac	Gac	18	18	AY.103	0.000112
S	145	Y145Y	taC	taT	17	17	AY.27	0.0011
S	145	Y145N	Tac	Aac	16	17	AY.44	0.000097
S	145	Y145N	TaC	AaT	1	17	AY.44	0.000006
S	145	Y145H	Tac	Cac	17	17	B.1.621	0.001505
S	145	Y145T	TAc	ACc	9	16	All	0.000002
S	145	Y145T	TAC	ACT	7	16	All	0.000001
S	145	Y145del	TAC	---	16	16	AY.4.2	0.000347
S	145	Y145D	Tac	Gac	16	16	B.1.1	0.00029
S	145	Y145Y	taC	taT	15	15	AY.29	0.000237
S	145	Y145Y	taC	taT	15	15	AY.47	0.000467
S	145	Y145Y	taC	taT	15	15	B.1.621	0.001328
S	145	Y145del	TAC	---	15	15	P.1	0.000236
S	145	Y145N	Tac	Aac	14	14	AY.43	0.000062
S	145	Y145C	tAC	tGT	13	14	AY.44	0.000079
S	145	Y145C	tAc	tGc	1	14	AY.44	0.000006
S	145	Y145Y	taC	taT	14	14	AY.75	0.000784
S	145	Y145Y	taC	taT	14	14	B.1.232	0.007523
S	145	Y145H	Tac	Cac	14	14	B.1.427	0.000707
S	145	Y145D	Tac	Gac	14	14	B.1.429	0.000329
S	145	Y145D	Tac	Gac	14	14	B.1.526	0.000329
S	145	Y145del	TAC	---	14	14	B.1.582	0.006869
S	145	Y145L	tAC	tTA	12	13	All	0.000002
S	145	Y145X	taC	taA	10	13	All	0.000002
S	145	Y145X	taC	taG	3	13	All	0.000001
S	145	Y145L	TAc	CTc	1	13	All	0
S	145	Y145H	Tac	Cac	13	13	AY.120	0.000483
S	145	Y145D	Tac	Gac	13	13	AY.25	0.000078
S	145	Y145D	Tac	Gac	13	13	B.1.351	0.000386
S	145	Y145del	TAC	---	12	12	AY.102	0.000318
S	145	Y145Y	taC	taT	12	12	B.1.214.2	0.007194
S	145	Y145Y	taC	taT	12	12	B.1.381	0.09375
S	145	Y145del	TAC	---	12	12	B.1.617.2	0.000045
S	145	Y145del1	Tac	-ac	12	12	B.1.621	0.001062
S	145	Y145T	TAC	ACT	6	12	B.1.621	0.000531
S	145	Y145T	TAc	ACc	6	12	B.1.621	0.000531
S	145	Y145Y	taC	taT	11	11	AY.113	0.001566
S	145	Y145N	Tac	Aac	11	11	AY.26	0.000311
S	145	Y145Y	taC	taT	11	11	AY.59	0.005826
S	145	Y145D	Tac	Gac	11	11	B.1.1.37	0.002122
S	145	Y145del	TAC	---	11	11	B.1.177	0.000145
S	145	Y145Y	taC	taT	11	11	B.1.177.64	1
S	145	Y145Y	taC	taT	11	11	B.1.596	0.000959
S	145	Y145H	Tac	Cac	10	10	AY.103	0.000062
S	145	Y145del	TAC	---	10	10	AY.42	0.000402
S	145	Y145Y	taC	taT	10	10	AY.46.5	0.001984
S	145	Y145N	Tac	Aac	10	10	B	0.001278
S	145	Y145Y	taC	taT	10	10	B.1.1.28	0.003112
S	145	Y145D	Tac	Gac	9	9	AY.100	0.000414
S	145	Y145Y	taC	taT	9	9	AY.20	0.00035
S	145	Y145del	TAC	---	9	9	AY.44	0.000055
S	145	Y145H	Tac	Cac	9	9	AY.52	0.007329
S	145	Y145del	TAC	---	9	9	B.1.1	0.000163
S	145	Y145Y	taC	taT	9	9	B.1.1.214	0.000499
S	145	Y145D	Tac	Gac	9	9	B.1.2	0.000079
S	145	Y145Y	taC	taT	9	9	B.1.234	0.001187
S	145	Y145Y	taC	taT	9	9	B.1.369	0.002567
S	145	Y145Y	taC	taT	9	9	P.1.15	0.002091
S	145	Y145N	Tac	Aac	8	8	AY.20	0.000311
S	145	Y145H	Tac	Cac	8	8	AY.45	0.000973
S	145	Y145H	Tac	Cac	8	8	AY.7.2	0.004474
S	145	Y145H	Tac	Cac	8	8	B.1	0.000073
S	145	Y145N	Tac	Aac	8	8	B.1.1	0.000145
S	145	Y145Y	taC	taT	8	8	B.1.1.519	0.000318
S	145	Y145del1	TAC	CG-	3	8	B.1.1.7	0.000003
S	145	Y145del1	TAc	-Nc	2	8	B.1.1.7	0.000002
S	145	Y145del1	Tac	-ac	2	8	B.1.1.7	0.000002
S	145	Y145del1	taC	ta-	1	8	B.1.1.7	0.000001
S	145	Y145del	TAC	---	8	8	B.1.160	0.00025
S	145	Y145Y	taC	taT	8	8	B.1.160.10	0.064516
S	145	Y145N	Tac	Aac	8	8	B.1.177.73	0.00453
S	145	Y145D	Tac	Gac	8	8	B.1.258	0.000532
S	145	Y145N	Tac	Aac	8	8	B.1.351	0.000238
S	145	Y145D	Tac	Gac	8	8	B.1.427	0.000404
S	145	Y145Y	taC	taT	8	8	B.1.617.1	0.001032
S	145	Y145D	Tac	Gac	8	8	B.1.621	0.000708
S	145	Y145del	TAC	---	8	8	B.1.630	0.041885
S	145	Y145Y	taC	taT	7	7	A.23.1	0.00493
S	145	Y145del	TAC	---	7	7	AY.3	0.00007
S	145	Y145C	tAC	tGT	7	7	AY.39	0.000173
S	145	Y145S	tAc	tCc	7	7	B.1.1.7	0.000006
S	145	Y145L	tAC	tTA	7	7	B.1.1.7	0.000006
S	145	Y145H	Tac	Cac	7	7	B.1.177	0.000092
S	145	Y145Y	taC	taT	7	7	B.1.351.2	0.002118
S	145	Y145D	Tac	Gac	7	7	B.1.574	0.015054
S	145	Y145D	Tac	Gac	7	7	B.1.617.1	0.000903
S	145	Y145Y	taC	taT	7	7	D.2	0.000525
S	145	Y145H	Tac	Cac	7	7	P.1	0.00011
S	145	Y145D	Tac	Gac	7	7	P.1.7	0.002235
S	145	Y145C	tAC	tGT	6	6	AY.103	0.000037
S	145	Y145N	Tac	Aac	6	6	AY.103	0.000037
S	145	Y145H	Tac	Cac	6	6	AY.119	0.000212
S	145	Y145del	TAC	---	6	6	AY.29	0.000095
S	145	Y145Y	taC	taT	6	6	AY.39.1	0.000238
S	145	Y145D	Tac	Gac	6	6	AY.43	0.000027
S	145	Y145D	Tac	Gac	6	6	AY.44	0.000037
S	145	Y145H	Tac	Cac	6	6	AY.46.2	0.003812
S	145	Y145H	Tac	Cac	6	6	AY.84	0.002625
S	145	Y145Y	taC	taT	6	6	B.1.1.294	0.007595
S	145	Y145del	TAC	---	6	6	B.1.1.318	0.001811
S	145	Y145D	Tac	Gac	6	6	B.1.1.519	0.000238
S	145	Y145Y	taC	taT	6	6	B.1.110.3	0.00431
S	145	Y145Y	taC	taT	6	6	B.1.351	0.000178
S	145	Y145del	TAC	---	6	6	B.1.351	0.000178
S	145	Y145Y	taC	taT	6	6	P.1.14	0.000287
S	145	Y145D	Tac	Gac	6	6	P.1.15	0.001394
S	145	Y145Y	taC	taT	5	5	A.2.5.3	0.051546
S	145	Y145K	TaC	AaA	5	5	All	0.000001
S	145	Y145N	Tac	Aac	5	5	AY.102	0.000133
S	145	Y145Y	taC	taT	5	5	AY.106	0.001674
S	145	Y145Y	taC	taT	5	5	AY.28	0.009452
S	145	Y145D	Tac	Gac	5	5	AY.3	0.00005
S	145	Y145del	TAC	---	5	5	AY.39	0.000124
S	145	Y145S	tAc	tCc	5	5	AY.4	0.000008
S	145	Y145del	TAC	---	5	5	AY.4.2.1	0.000745
S	145	Y145H	Tac	Cac	5	5	AY.46.6	0.000361
S	145	Y145H	Tac	Cac	5	5	AY.5	0.000103
S	145	Y145Y	taC	taT	5	5	AY.61	0.000524
S	145	Y145H	Tac	Cac	5	5	AY.75.1	0.000902
S	145	Y145Y	taC	taT	5	5	AY.85	0.002136
S	145	Y145Y	taC	taT	5	5	AY.98	0.000395
S	145	Y145D	Tac	Gac	5	5	AY.98.1	0.000242
S	145	Y145C	tAc	tGc	5	5	B.1.1.1	0.001633
S	145	Y145Y	taC	taT	5	5	B.1.177.86	0.000917
S	145	Y145D	Tac	Gac	5	5	B.1.351.3	0.004382
S	145	Y145Y	taC	taT	5	5	B.1.409	0.003906
S	145	Y145F	tAc	tTc	5	5	B.1.621	0.000443
S	145	Y145S	tAC	tCT	5	5	B.1.621.1	0.002529
S	145	Y145Y	taC	taT	5	5	C.36.3	0.002836
S	145	Y145N	Tac	Aac	5	5	P.1	0.000079
S	145	Y145P	TAC	CCT	2	4		0.111111
S	145	Y145P	TAc	CCc	2	4		0.111111
S	145	Y145del	TAC	---	4	4	A.2.5	0.001996
S	145	Y145Y	taC	taT	4	4	AD.2	0.000876
S	145	Y145P	TAC	CCT	2	4	All	0
S	145	Y145P	TAc	CCc	2	4	All	0
S	145	Y145H	Tac	Cac	4	4	AY.100	0.000184
S	145	Y145del	TAC	---	4	4	AY.103	0.000025
S	145	Y145N	Tac	Aac	4	4	AY.117	0.000338
S	145	Y145Y	taC	taT	4	4	AY.119	0.000141
S	145	Y145H	Tac	Cac	4	4	AY.120.1	0.001284
S	145	Y145H	Tac	Cac	4	4	AY.20	0.000155
S	145	Y145C	tAC	tGT	3	4	AY.25	0.000018
S	145	Y145C	tAc	tGc	1	4	AY.25	0.000006
S	145	Y145N	Tac	Aac	4	4	AY.3	0.00004
S	145	Y145Y	taC	taT	4	4	AY.33	0.000267
S	145	Y145del	TAC	---	4	4	AY.34.1	0.00204
S	145	Y145Y	taC	taT	4	4	AY.39.2	0.006163
S	145	Y145N	Tac	Aac	3	4	AY.4	0.000005
S	145	Y145N	TaC	AaT	1	4	AY.4	0.000002
S	145	Y145D	Tac	Gac	4	4	AY.4.4	0.001637
S	145	Y145D	Tac	Gac	4	4	AY.46	0.000416
S	145	Y145Y	taC	taT	4	4	AY.46.4	0.000658
S	145	Y145H	Tac	Cac	4	4	AY.5.3	0.00135
S	145	Y145H	Tac	Cac	4	4	AY.6	0.000165
S	145	Y145D	Tac	Gac	4	4	AY.75	0.000224
S	145	Y145H	Tac	Cac	4	4	AY.75	0.000224
S	145	Y145Y	taC	taT	4	4	AY.75.1	0.000721
S	145	Y145Y	taC	taT	4	4	AY.88	0.003537
S	145	Y145Y	taC	taT	4	4	AY.9.2	0.000147
S	145	Y145N	Tac	Aac	4	4	AY.92	0.001149
S	145	Y145Y	taC	taT	4	4	AY.98.1	0.000194
S	145	Y145del	TAC	---	4	4	AZ.2	0.003284
S	145	Y145F	tAc	tTc	4	4	B.1	0.000037
S	145	Y145D	Tac	Gac	4	4	B.1.1.218	0.030769
S	145	Y145D	Tac	Gac	4	4	B.1.160	0.000125
S	145	Y145Y	taC	taT	4	4	B.1.177.12	0.000607
S	145	Y145del	TAC	---	4	4	B.1.177.21	0.000306
S	145	Y145D	Tac	Gac	4	4	B.1.177.81	0.000757
S	145	Y145del	TAC	---	4	4	B.1.243	0.000278
S	145	Y145Y	taC	taT	4	4	B.1.408	0.01476
S	145	Y145D	Tac	Gac	4	4	B.1.637	0.000292
S	145	Y145Y	taC	taT	4	4	C.37	0.000464
S	145	Y145Y	taC	taT	4	4	P.1.1	0.001271
S	145	Y145D	Tac	Gac	4	4	P.1.10	0.001078
S	145	Y145N	Tac	Aac	3	3	A	0.001161
S	145	Y145Y	taC	taT	3	3	A.2	0.001985
S	145	Y145N	Tac	Aac	3	3	A.2.5	0.001497
S	145	Y145Y	taC	taT	3	3	A.2.5	0.001497
S	145	Y145Y	taC	taT	3	3	AY.1	0.001187
S	145	Y145N	Tac	Aac	3	3	AY.100	0.000138
S	145	Y145N	Tac	Aac	3	3	AY.110	0.000338
S	145	Y145Y	taC	taT	3	3	AY.110	0.000338
S	145	Y145Y	taC	taT	3	3	AY.111	0.000549
S	145	Y145del	TAC	---	3	3	AY.120	0.000112
S	145	Y145del	TAC	---	3	3	AY.121	0.000406
S	145	Y145H	Tac	Cac	3	3	AY.13	0.000483
S	145	Y145Y	taC	taT	3	3	AY.13	0.000483
S	145	Y145Y	taC	taT	3	3	AY.23	0.000209
S	145	Y145N	Tac	Aac	3	3	AY.39	0.000074
S	145	Y145D	Tac	Gac	3	3	AY.39	0.000074
S	145	Y145del1	Tac	-ac	2	3	AY.4	0.000003
S	145	Y145del1	tAc	t-c	1	3	AY.4	0.000002
S	145	Y145D	Tac	Gac	3	3	AY.4.2.1	0.000447
S	145	Y145N	Tac	Aac	3	3	AY.4.2.1	0.000447
S	145	Y145N	Tac	Aac	3	3	AY.42	0.000121
S	145	Y145H	Tac	Cac	3	3	AY.42	0.000121
S	145	Y145D	Tac	Gac	3	3	AY.65	0.001599
S	145	Y145Y	taC	taT	3	3	AY.7.1	0.000338
S	145	Y145Y	taC	taT	3	3	AY.9.1	0.000251
S	145	Y145H	Tac	Cac	3	3	AY.93	0.000819
S	145	Y145H	Tac	Cac	3	3	AY.95	0.002283
S	145	Y145H	Tac	Cac	3	3	AY.98	0.000237
S	145	Y145D	Tac	Gac	3	3	AY.98	0.000237
S	145	Y145X	taC	taA	2	3	B.1	0.000018
S	145	Y145X	taC	taG	1	3	B.1	0.000009
S	145	Y145del	TAC	---	3	3	B.1.1.284	0.000322
S	145	Y145Y	taC	taT	3	3	B.1.1.432	0.003797
S	145	Y145D	Tac	Gac	3	3	B.1.177.58	0.003995
S	145	Y145D	Tac	Gac	3	3	B.1.177.62	0.003576
S	145	Y145Y	taC	taT	3	3	B.1.240	0.000647
S	145	Y145Y	taC	taT	3	3	B.1.241	0.002435
S	145	Y145del	TAC	---	3	3	B.1.319	0.009146
S	145	Y145Y	taC	taT	3	3	B.1.36	0.000438
S	145	Y145del	TAC	---	3	3	B.1.36	0.000438
S	145	Y145N	Tac	Aac	3	3	B.1.429	0.000071
S	145	Y145D	Tac	Gac	3	3	B.1.596	0.000261
S	145	Y145del	TAC	---	3	3	B.1.596	0.000261
S	145	Y145H	Tac	Cac	3	3	B.1.617.1	0.000387
S	145	Y145D	Tac	Gac	3	3	B.1.617.2	0.000011
S	145	Y145del	TAC	---	3	3	B.1.621	0.000266
S	145	Y145D	Tac	Gac	3	3	B.1.621.1	0.001517
S	145	Y145Y	taC	taT	3	3	B.1.628	0.001057
S	145	Y145Y	taC	taT	3	3	B.6.6	0.002667
S	145	Y145H	Tac	Cac	3	3	C.37	0.000348
S	145	Y145Y	taC	taT	3	3	P.1.12	0.001452
S	145	Y145H	Tac	Cac	3	3	P.1.15	0.000697
S	145	Y145Y	taC	taT	3	3	P.1.17	0.000485
S	145	Y145Y	taC	taT	3	3	P.2	0.00056
S	145	Y145Y	taC	taT	3	3	R.1	0.00027
S	145	Y145H	Tac	Cac	2	2		0.111111
S	145	Y145del2	TAc	--c	2	2		0.111111
S	145	Y145S	tAC	tCT	1	2		0.055556
S	145	Y145S	tAc	tCc	1	2		0.055556
S	145	Y145Y	taC	taT	2	2	A.1	0.000564
S	145	Y145N	Tac	Aac	2	2	A.2.5.1	0.009615
S	145	Y145del	TAC	---	2	2	A.27	0.003311
S	145	Y145Q	TaC	CaA	1	2	All	0
S	145	Y145I	TAC	ATT	1	2	All	0
S	145	Y145I	TAc	ATc	1	2	All	0
S	145	Y145Q	TaC	CaG	1	2	All	0
S	145	Y145H	Tac	Cac	2	2	AP.1	0.003003
S	145	Y145del	TAC	---	2	2	AY.100	0.000092
S	145	Y145del	TAC	---	2	2	AY.101	0.000981
S	145	Y145D	Tac	Gac	2	2	AY.102	0.000053
S	145	Y145del	TAC	---	2	2	AY.108	0.002205
S	145	Y145H	Tac	Cac	2	2	AY.117	0.000169
S	145	Y145del	TAC	---	2	2	AY.119	0.000071
S	145	Y145N	Tac	Aac	2	2	AY.119	0.000071
S	145	Y145N	Tac	Aac	2	2	AY.23	0.000139
S	145	Y145Y	taC	taT	2	2	AY.23.1	0.000835
S	145	Y145H	Tac	Cac	2	2	AY.26	0.000057
S	145	Y145del	TAC	---	2	2	AY.27	0.000129
S	145	Y145N	Tac	Aac	2	2	AY.29	0.000032
S	145	Y145H	TaC	CaT	1	2	AY.29	0.000016
S	145	Y145H	Tac	Cac	1	2	AY.29	0.000016
S	145	Y145Y	taC	taT	2	2	AY.29.1	0.000441
S	145	Y145del	TAC	---	2	2	AY.29.1	0.000441
S	145	Y145C	tAC	tGT	2	2	AY.3	0.00002
S	145	Y145del	TAC	---	2	2	AY.33	0.000134
S	145	Y145N	Tac	Aac	2	2	AY.35	0.000466
S	145	Y145H	Tac	Cac	2	2	AY.36	0.000296
S	145	Y145H	Tac	Cac	2	2	AY.39.1	0.000079
S	145	Y145C	tAc	tGc	2	2	AY.4	0.000003
S	145	Y145del	TAC	---	2	2	AY.4.5	0.000215
S	145	Y145H	Tac	Cac	2	2	AY.40	0.001929
S	145	Y145del1	taC	ta-	1	2	AY.43	0.000004
S	145	Y145del1	Tac	-ac	1	2	AY.43	0.000004
S	145	Y145Y	taC	taT	2	2	AY.45	0.000243
S	145	Y145del1	TAc	-Nc	2	2	AY.45	0.000243
S	145	Y145H	Tac	Cac	2	2	AY.46	0.000208
S	145	Y145N	Tac	Aac	2	2	AY.46	0.000208
S	145	Y145H	Tac	Cac	2	2	AY.46.1	0.002053
S	145	Y145H	Tac	Cac	2	2	AY.46.5	0.000397
S	145	Y145Y	taC	taT	2	2	AY.46.6	0.000144
S	145	Y145N	Tac	Aac	2	2	AY.52	0.001629
S	145	Y145Y	taC	taT	2	2	AY.53	0.000575
S	145	Y145C	tAC	tGT	2	2	AY.54	0.000191
S	145	Y145H	Tac	Cac	2	2	AY.54	0.000191
S	145	Y145Y	taC	taT	2	2	AY.55	0.001835
S	145	Y145Y	taC	taT	2	2	AY.6	0.000082
S	145	Y145del	TAC	---	2	2	AY.65	0.001066
S	145	Y145N	Tac	Aac	2	2	AY.67	0.000929
S	145	Y145H	Tac	Cac	2	2	AY.68	0.000547
S	145	Y145Y	taC	taT	2	2	AY.69	0.000373
S	145	Y145del	TAC	---	2	2	AY.7.2	0.001119
S	145	Y145N	Tac	Aac	2	2	AY.75	0.000112
S	145	Y145N	Tac	Aac	2	2	AY.75.1	0.000361
S	145	Y145del	TAC	---	2	2	AY.84	0.000875
S	145	Y145del	TAC	---	2	2	AY.9	0.000135
S	145	Y145Y	taC	taT	2	2	AY.9	0.000135
S	145	Y145H	Tac	Cac	2	2	AY.9.1	0.000167
S	145	Y145D	Tac	Gac	2	2	AY.9.2	0.000073
S	145	Y145H	Tac	Cac	2	2	AY.91	0.001461
S	145	Y145del	TAC	---	2	2	AY.98.1	0.000097
S	145	Y145H	Tac	Cac	2	2	AY.98.1	0.000097
S	145	Y145del	TAC	---	2	2	AY.99	0.002099
S	145	Y145del	TAC	---	2	2	AZ.5	0.007018
S	145	Y145C	tAc	tGc	2	2	B.1	0.000018
S	145	Y145del2	TAC	--A	1	2	B.1.1	0.000018
S	145	Y145del2	tAC	t--	1	2	B.1.1	0.000018
S	145	Y145Y	taC	taT	2	2	B.1.1.221	0.020202
S	145	Y145del	TAC	---	2	2	B.1.1.298	0.001724
S	145	Y145Y	taC	taT	2	2	B.1.1.306	0.000877
S	145	Y145del	TAC	---	2	2	B.1.1.311	0.000716
S	145	Y145H	Tac	Cac	2	2	B.1.1.317	0.000823
S	145	Y145Y	taC	taT	2	2	B.1.1.317	0.000823
S	145	Y145D	Tac	Gac	2	2	B.1.1.318	0.000604
S	145	Y145Y	taC	taT	2	2	B.1.1.326	0.003521
S	145	Y145Y	taC	taT	2	2	B.1.1.351	0.005587
S	145	Y145D	Tac	Gac	2	2	B.1.1.368	0.006173
S	145	Y145H	Tac	Cac	2	2	B.1.1.519	0.000079
S	145	Y145T	TAc	ACc	2	2	B.1.1.7	0.000002
S	145	Y145Y	taC	taT	2	2	B.1.1.7	0.000002
S	145	Y145F	tAc	tTc	2	2	B.1.1.7	0.000002
S	145	Y145Y	taC	taT	2	2	B.1.13	0.004751
S	145	Y145N	Tac	Aac	2	2	B.1.157	0.00597
S	145	Y145H	Tac	Cac	2	2	B.1.160	0.000062
S	145	Y145Y	taC	taT	2	2	B.1.177.7	0.00033
S	145	Y145del	TAC	---	2	2	B.1.177.87	0.001456
S	145	Y145del1	tAc	t-c	1	2	B.1.2	0.000009
S	145	Y145del1	taC	ta-	1	2	B.1.2	0.000009
S	145	Y145del	TAC	---	2	2	B.1.221	0.000142
S	145	Y145del	TAC	---	2	2	B.1.234	0.000264
S	145	Y145del	TAC	---	2	2	B.1.258.17	0.000208
S	145	Y145Y	taC	taT	2	2	B.1.279	0.001027
S	145	Y145D	Tac	Gac	2	2	B.1.324	0.00321
S	145	Y145H	Tac	Cac	2	2	B.1.344	0.016393
S	145	Y145H	Tac	Cac	2	2	B.1.351.5	0.001199
S	145	Y145Y	taC	taT	2	2	B.1.36.18	0.00084
S	145	Y145Y	taC	taT	2	2	B.1.36.29	0.001035
S	145	Y145del	TAC	---	2	2	B.1.36.38	0.003284
S	145	Y145D	Tac	Gac	2	2	B.1.367	0.001585
S	145	Y145H	Tac	Cac	2	2	B.1.385	0.021277
S	145	Y145del	TAC	---	2	2	B.1.39	0.007812
S	145	Y145D	Tac	Gac	2	2	B.1.438.1	0.000215
S	145	Y145del	TAC	---	2	2	B.1.525	0.000226
S	145	Y145N	Tac	Aac	2	2	B.1.533	0.019231
S	145	Y145Y	taC	taT	2	2	B.1.564	0.000852
S	145	Y145H	Tac	Cac	2	2	B.1.582	0.000981
S	145	Y145Y	taC	taT	2	2	B.1.582	0.000981
S	145	Y145del	TAC	---	2	2	B.1.595	0.000522
S	145	Y145Y	taC	taT	2	2	B.1.595	0.000522
S	145	Y145Y	taC	taT	2	2	B.1.612	0.005305
S	145	Y145del	TAC	---	2	2	B.1.617.1	0.000258
S	145	Y145del	TAC	---	2	2	B.1.620	0.001892
S	145	Y145L	tAC	tTA	2	2	B.1.621	0.000177
S	145	Y145H	Tac	Cac	2	2	B.1.625	0.004706
S	145	Y145del1	taC	ta-	2	2	B.1.627	0.00404
S	145	Y145H	Tac	Cac	2	2	B.1.637	0.000146
S	145	Y145Y	taC	taT	2	2	B.1.9.4	0.01227
S	145	Y145del	TAC	---	2	2	C.37	0.000232
S	145	Y145del	TAC	---	2	2	P.1.11	0.020408
S	145	Y145N	Tac	Aac	2	2	P.1.12	0.000968
S	145	Y145del	TAC	---	2	2	P.1.15	0.000465
S	145	Y145D	Tac	Gac	2	2	P.1.6	0.003891
S	145	Y145D	Tac	Gac	2	2	P.2	0.000373
S	145	Y145del	TAC	---	2	2	P.3	0.00319
S	145	Y145H	Tac	Cac	2	2	P.3	0.00319
S	145	Y145del	TAC	---	2	2	Q.2	0.001227
S	145	Y145del	TAC	---	2	2	Q.3	0.00029
S	145	Y145Y	taC	taT	1	1		0.055556
S	145	Y145F	tAc	tTc	1	1		0.055556
S	145	Y145del	TAC	---	1	1	A	0.000387
S	145	Y145X	taC	taA	1	1	A	0.000387
S	145	Y145del	TAC	---	1	1	A.1	0.000282
S	145	Y145H	Tac	Cac	1	1	A.1	0.000282
S	145	Y145del	TAC	---	1	1	A.19	0.009434
S	145	Y145H	Tac	Cac	1	1	A.2.5	0.000499
S	145	Y145N	Tac	Aac	1	1	A.23.1	0.000704
S	145	Y145Y	taC	taT	1	1	AC.1	0.037037
S	145	Y145del1	TAC	-NN	1	1	AD.2	0.000219
S	145	Y145V	TAc	GTc	1	1	All	0
S	145	Y145E	TaC	GaA	1	1	All	0
S	145	Y145G	TAc	GGc	1	1	All	0
S	145	Y145A	TAc	GCc	1	1	All	0
S	145	Y145D	Tac	Gac	1	1	AU.3	0.00211
S	145	Y145N	Tac	Aac	1	1	AY.1	0.000396
S	145	Y145D	Tac	Gac	1	1	AY.10	0.00053
S	145	Y145N	Tac	Aac	1	1	AY.101	0.00049
S	145	Y145del1	taC	ta-	1	1	AY.101	0.00049
S	145	Y145F	tAc	tTc	1	1	AY.102	0.000027
S	145	Y145C	tAc	tGc	1	1	AY.102	0.000027
S	145	Y145H	Tac	Cac	1	1	AY.106	0.000335
S	145	Y145D	Tac	Gac	1	1	AY.106	0.000335
S	145	Y145del	TAC	---	1	1	AY.107	0.000466
S	145	Y145D	Tac	Gac	1	1	AY.107	0.000466
S	145	Y145H	Tac	Cac	1	1	AY.108	0.001103
S	145	Y145del	TAC	---	1	1	AY.109	0.00074
S	145	Y145H	Tac	Cac	1	1	AY.109	0.00074
S	145	Y145H	Tac	Cac	1	1	AY.110	0.000113
S	145	Y145H	Tac	Cac	1	1	AY.111	0.000183
S	145	Y145N	Tac	Aac	1	1	AY.113	0.000142
S	145	Y145C	tAC	tGT	1	1	AY.114	0.000231
S	145	Y145H	Tac	Cac	1	1	AY.114	0.000231
S	145	Y145Y	taC	taT	1	1	AY.114	0.000231
S	145	Y145Y	taC	taT	1	1	AY.116	0.000287
S	145	Y145del	TAC	---	1	1	AY.116	0.000287
S	145	Y145del	TAC	---	1	1	AY.117	0.000085
S	145	Y145del	TAC	---	1	1	AY.118	0.000063
S	145	Y145C	tAC	tGT	1	1	AY.119	0.000035
S	145	Y145Y	taC	taT	1	1	AY.12	0.000316
S	145	Y145N	Tac	Aac	1	1	AY.12	0.000316
S	145	Y145D	Tac	Gac	1	1	AY.12	0.000316
S	145	Y145D	Tac	Gac	1	1	AY.120	0.000037
S	145	Y145del	TAC	---	1	1	AY.120.2	0.001285
S	145	Y145Y	taC	taT	1	1	AY.121	0.000135
S	145	Y145Y	taC	taT	1	1	AY.14	0.000088
S	145	Y145del	TAC	---	1	1	AY.14	0.000088
S	145	Y145Y	taC	taT	1	1	AY.16	0.00038
S	145	Y145Y	taC	taT	1	1	AY.22	0.002092
S	145	Y145L	tAC	tTA	1	1	AY.23	0.00007
S	145	Y145H	Tac	Cac	1	1	AY.23	0.00007
S	145	Y145X	taC	taA	1	1	AY.24	0.000431
S	145	Y145Y	taC	taT	1	1	AY.24	0.000431
S	145	Y145del1	taC	ta-	1	1	AY.25	0.000006
S	145	Y145N	Tac	Aac	1	1	AY.27	0.000065
S	145	Y145H	Tac	Cac	1	1	AY.29.1	0.000221
S	145	Y145D	Tac	Gac	1	1	AY.3.1	0.000085
S	145	Y145Y	taC	taT	1	1	AY.3.1	0.000085
S	145	Y145Y	taC	taT	1	1	AY.30	0.000396
S	145	Y145H	Tac	Cac	1	1	AY.32	0.000532
S	145	Y145C	tAC	tGT	1	1	AY.33	0.000067
S	145	Y145F	tAc	tTc	1	1	AY.34	0.000097
S	145	Y145Y	taC	taT	1	1	AY.34	0.000097
S	145	Y145N	Tac	Aac	1	1	AY.34.1	0.00051
S	145	Y145D	Tac	Gac	1	1	AY.35	0.000233
S	145	Y145H	Tac	Cac	1	1	AY.35	0.000233
S	145	Y145del	TAC	---	1	1	AY.36	0.000148
S	145	Y145del1	Tac	-ac	1	1	AY.36	0.000148
S	145	Y145Y	taC	taT	1	1	AY.36	0.000148
S	145	Y145N	Tac	Aac	1	1	AY.36	0.000148
S	145	Y145Y	taC	taT	1	1	AY.38	0.000499
S	145	Y145del1	TAc	-Nc	1	1	AY.38	0.000499
S	145	Y145D	Tac	Gac	1	1	AY.39.1	0.00004
S	145	Y145F	tAc	tTc	1	1	AY.4	0.000002
S	145	Y145K	TaC	AaA	1	1	AY.4	0.000002
S	145	Y145del	TAC	---	1	1	AY.4.1	0.000737
S	145	Y145D	Tac	Gac	1	1	AY.4.2	0.000022
S	145	Y145Q	TaC	CaG	1	1	AY.4.2.1	0.000149
S	145	Y145N	Tac	Aac	1	1	AY.4.3	0.000842
S	145	Y145H	Tac	Cac	1	1	AY.4.5	0.000107
S	145	Y145X	taC	taA	1	1	AY.42	0.00004
S	145	Y145K	TaC	AaA	1	1	AY.43	0.000004
S	145	Y145I	TAc	ATc	1	1	AY.43	0.000004
S	145	Y145C	tAc	tGc	1	1	AY.43	0.000004
S	145	Y145X	taC	taA	1	1	AY.43	0.000004
S	145	Y145D	Tac	Gac	1	1	AY.45	0.000122
S	145	Y145N	Tac	Aac	1	1	AY.45	0.000122
S	145	Y145del	TAC	---	1	1	AY.46	0.000104
S	145	Y145Y	taC	taT	1	1	AY.46	0.000104
S	145	Y145Y	taC	taT	1	1	AY.46.2	0.000635
S	145	Y145H	Tac	Cac	1	1	AY.46.4	0.000165
S	145	Y145N	Tac	Aac	1	1	AY.46.6	0.000072
S	145	Y145N	Tac	Aac	1	1	AY.47	0.000031
S	145	Y145D	TaC	GaT	1	1	AY.47	0.000031
S	145	Y145H	Tac	Cac	1	1	AY.47	0.000031
S	145	Y145N	Tac	Aac	1	1	AY.48	0.000465
S	145	Y145D	Tac	Gac	1	1	AY.5	0.000021
S	145	Y145del	TAC	---	1	1	AY.5	0.000021
S	145	Y145N	Tac	Aac	1	1	AY.5.3	0.000337
S	145	Y145del	TAC	---	1	1	AY.5.3	0.000337
S	145	Y145Y	taC	taT	1	1	AY.51	0.000909
S	145	Y145Y	taC	taT	1	1	AY.52	0.000814
S	145	Y145N	Tac	Aac	1	1	AY.53	0.000288
S	145	Y145N	Tac	Aac	1	1	AY.54	0.000095
S	145	Y145Y	taC	taT	1	1	AY.54	0.000095
S	145	Y145Y	taC	taT	1	1	AY.56	0.001605
S	145	Y145Y	taC	taT	1	1	AY.57	0.000656
S	145	Y145H	Tac	Cac	1	1	AY.58	0.000907
S	145	Y145X	taC	taA	1	1	AY.59	0.00053
S	145	Y145T	TAC	ACT	1	1	AY.59	0.00053
S	145	Y145del	TAC	---	1	1	AY.60	0.000938
S	145	Y145D	Tac	Gac	1	1	AY.61	0.000105
S	145	Y145F	tAc	tTc	1	1	AY.61	0.000105
S	145	Y145D	Tac	Gac	1	1	AY.62	0.000436
S	145	Y145Y	taC	taT	1	1	AY.62	0.000436
S	145	Y145del	TAC	---	1	1	AY.62	0.000436
S	145	Y145Y	taC	taT	1	1	AY.64	0.000595
S	145	Y145Y	taC	taT	1	1	AY.65	0.000533
S	145	Y145C	tAC	tGT	1	1	AY.65	0.000533
S	145	Y145Y	taC	taT	1	1	AY.72	0.001361
S	145	Y145del	TAC	---	1	1	AY.73	0.000665
S	145	Y145Y	taC	taT	1	1	AY.74	0.000116
S	145	Y145D	Tac	Gac	1	1	AY.74	0.000116
S	145	Y145N	Tac	Aac	1	1	AY.74	0.000116
S	145	Y145C	tAC	tGT	1	1	AY.75	0.000056
S	145	Y145del	TAC	---	1	1	AY.78	0.001541
S	145	Y145Y	taC	taT	1	1	AY.78	0.001541
S	145	Y145C	tAC	tGT	1	1	AY.81	0.001992
S	145	Y145H	Tac	Cac	1	1	AY.82	0.001357
S	145	Y145del	TAC	---	1	1	AY.85	0.000427
S	145	Y145H	Tac	Cac	1	1	AY.87	0.000833
S	145	Y145N	Tac	Aac	1	1	AY.9	0.000068
S	145	Y145F	tAc	tTc	1	1	AY.9.1	0.000084
S	145	Y145D	Tac	Gac	1	1	AY.9.1	0.000084
S	145	Y145H	Tac	Cac	1	1	AY.9.2	0.000037
S	145	Y145del	TAC	---	1	1	AY.9.2	0.000037
S	145	Y145H	Tac	Cac	1	1	AY.9.2.1	0.001976
S	145	Y145del1	TAc	-Nc	1	1	AY.91	0.00073
S	145	Y145del	TAC	---	1	1	AY.92	0.000287
S	145	Y145Y	taC	taT	1	1	AY.92	0.000287
S	145	Y145D	Tac	Gac	1	1	AY.92	0.000287
S	145	Y145D	Tac	Gac	1	1	AY.95	0.000761
S	145	Y145T	TAc	ACc	1	1	AY.98	0.000079
S	145	Y145Y	taC	taT	1	1	AY.99	0.001049
S	145	Y145H	Tac	Cac	1	1	AY.99	0.001049
S	145	Y145del	TAC	---	1	1	AY.99.1	0.001553
S	145	Y145H	Tac	Cac	1	1	AY.99.2	0.000092
S	145	Y145N	Tac	Aac	1	1	AY.99.2	0.000092
S	145	Y145S	tAc	tCc	1	1	B	0.000128
S	145	Y145S	tAc	tCc	1	1	B.1	0.000009
S	145	Y145L	tAC	tTA	1	1	B.1	0.000009
S	145	Y145del1	Tac	-ac	1	1	B.1	0.000009
S	145	Y145H	Tac	Cac	1	1	B.1.1	0.000018
S	145	Y145C	tAc	tGc	1	1	B.1.1	0.000018
S	145	Y145del1	tAc	t-c	1	1	B.1.1	0.000018
S	145	Y145Y	taC	taT	1	1	B.1.1.1	0.000327
S	145	Y145del1	Tac	-ac	1	1	B.1.1.1	0.000327
S	145	Y145del	TAC	---	1	1	B.1.1.139	0.022727
S	145	Y145Y	taC	taT	1	1	B.1.1.141	0.002012
S	145	Y145Y	taC	taT	1	1	B.1.1.157	0.000913
S	145	Y145N	Tac	Aac	1	1	B.1.1.161	0.003534
S	145	Y145Y	taC	taT	1	1	B.1.1.189	0.001513
S	145	Y145D	Tac	Gac	1	1	B.1.1.210	0.005714
S	145	Y145Y	taC	taT	1	1	B.1.1.216	0.00089
S	145	Y145D	Tac	Gac	1	1	B.1.1.219	0.005
S	145	Y145H	Tac	Cac	1	1	B.1.1.221	0.010101
S	145	Y145Y	taC	taT	1	1	B.1.1.222	0.000204
S	145	Y145N	Tac	Aac	1	1	B.1.1.236	0.006897
S	145	Y145D	Tac	Gac	1	1	B.1.1.25	0.000569
S	145	Y145H	Tac	Cac	1	1	B.1.1.25	0.000569
S	145	Y145D	Tac	Gac	1	1	B.1.1.263	0.001558
S	145	Y145N	Tac	Aac	1	1	B.1.1.263	0.001558
S	145	Y145D	Tac	Gac	1	1	B.1.1.269	0.001353
S	145	Y145N	Tac	Aac	1	1	B.1.1.28	0.000311
S	145	Y145Y	taC	taT	1	1	B.1.1.303	0.002762
S	145	Y145N	Tac	Aac	1	1	B.1.1.306	0.000438
S	145	Y145Y	taC	taT	1	1	B.1.1.311	0.000358
S	145	Y145D	Tac	Gac	1	1	B.1.1.316	0.000925
S	145	Y145del1	Tac	-ac	1	1	B.1.1.318	0.000302
S	145	Y145H	Tac	Cac	1	1	B.1.1.318	0.000302
S	145	Y145N	Tac	Aac	1	1	B.1.1.348	0.000796
S	145	Y145Y	taC	taT	1	1	B.1.1.348	0.000796
S	145	Y145Y	taC	taT	1	1	B.1.1.354	0.004386
S	145	Y145H	Tac	Cac	1	1	B.1.1.37	0.000193
S	145	Y145D	Tac	Gac	1	1	B.1.1.372	0.000689
S	145	Y145del	TAC	---	1	1	B.1.1.39	0.00051
S	145	Y145del	TAC	---	1	1	B.1.1.41	0.006329
S	145	Y145D	Tac	Gac	1	1	B.1.1.416	0.000905
S	145	Y145Y	taC	taT	1	1	B.1.1.419	0.007407
S	145	Y145del	TAC	---	1	1	B.1.1.432	0.001266
S	145	Y145del	TAC	---	1	1	B.1.1.447	0.035714
S	145	Y145Y	taC	taT	1	1	B.1.1.47	0.005348
S	145	Y145Y	taC	taT	1	1	B.1.1.486	0.001577
S	145	Y145Y	taC	taT	1	1	B.1.1.50	0.000679
S	145	Y145Y	taC	taT	1	1	B.1.1.517	0.006803
S	145	Y145N	Tac	Aac	1	1	B.1.1.523	0.001563
S	145	Y145Y	taC	taT	1	1	B.1.1.528	0.004808
S	145	Y145D	Tac	Gac	1	1	B.1.1.528	0.004808
S	145	Y145del	TAC	---	1	1	B.1.1.63	0.000386
S	145	Y145Y	taC	taT	1	1	B.1.1.63	0.000386
S	145	Y145D	Tac	Gac	1	1	B.1.1.63	0.000386
S	145	Y145Q	TaC	CaA	1	1	B.1.1.7	0.000001
S	145	Y145A	TAc	GCc	1	1	B.1.1.7	0.000001
S	145	Y145C	tAc	tGc	1	1	B.1.1.7	0.000001
S	145	Y145K	TaC	AaA	1	1	B.1.1.7	0.000001
S	145	Y145G	TAc	GGc	1	1	B.1.1.7	0.000001
S	145	Y145X	taC	taG	1	1	B.1.1.7	0.000001
S	145	Y145N	Tac	Aac	1	1	B.1.1.99	0.02381
S	145	Y145D	Tac	Gac	1	1	B.1.105	0.009615
S	145	Y145Y	taC	taT	1	1	B.1.110	0.004525
S	145	Y145Y	taC	taT	1	1	B.1.126	0.001276
S	145	Y145H	Tac	Cac	1	1	B.1.128	0.000635
S	145	Y145del	TAC	---	1	1	B.1.139	0.000733
S	145	Y145del	TAC	---	1	1	B.1.160.23	0.004831
S	145	Y145del	TAC	---	1	1	B.1.160.30	0.002976
S	145	Y145Y	taC	taT	1	1	B.1.160.7	0.002079
S	145	Y145X	taC	taA	1	1	B.1.166	0.008475
S	145	Y145N	Tac	Aac	1	1	B.1.167	0.007812
S	145	Y145N	Tac	Aac	1	1	B.1.177	0.000013
S	145	Y145X	taC	taA	1	1	B.1.177	0.000013
S	145	Y145Y	taC	taT	1	1	B.1.177.3	0.007634
S	145	Y145Y	taC	taT	1	1	B.1.177.4	0.000211
S	145	Y145del	TAC	---	1	1	B.1.177.4	0.000211
S	145	Y145D	Tac	Gac	1	1	B.1.177.4	0.000211
S	145	Y145Y	taC	taT	1	1	B.1.177.43	0.001477
S	145	Y145D	Tac	Gac	1	1	B.1.177.51	0.004566
S	145	Y145Y	taC	taT	1	1	B.1.177.53	0.002392
S	145	Y145Y	taC	taT	1	1	B.1.177.56	0.000668
S	145	Y145del	TAC	---	1	1	B.1.177.57	0.000281
S	145	Y145H	Tac	Cac	1	1	B.1.177.6	0.000977
S	145	Y145del	TAC	---	1	1	B.1.177.6	0.000977
S	145	Y145H	Tac	Cac	1	1	B.1.177.68	0.015152
S	145	Y145del	TAC	---	1	1	B.1.177.73	0.000566
S	145	Y145Y	taC	taT	1	1	B.1.177.74	0.015152
S	145	Y145Y	taC	taT	1	1	B.1.177.75	0.001041
S	145	Y145del	TAC	---	1	1	B.1.177.76	0.002494
S	145	Y145Y	taC	taT	1	1	B.1.177.81	0.000189
S	145	Y145del	TAC	---	1	1	B.1.177.86	0.000183
S	145	Y145H	Tac	Cac	1	1	B.1.180	0.05
S	145	Y145Y	taC	taT	1	1	B.1.189	0.004292
S	145	Y145N	Tac	Aac	1	1	B.1.2	0.000009
S	145	Y145C	tAc	tGc	1	1	B.1.2	0.000009
S	145	Y145Y	taC	taT	1	1	B.1.208	0.04
S	145	Y145Y	taC	taT	1	1	B.1.210	0.002132
S	145	Y145Y	taC	taT	1	1	B.1.214	0.003663
S	145	Y145H	Tac	Cac	1	1	B.1.220	0.01087
S	145	Y145del1	Tac	-ac	1	1	B.1.221	0.000071
S	145	Y145N	Tac	Aac	1	1	B.1.221	0.000071
S	145	Y145Y	taC	taT	1	1	B.1.221	0.000071
S	145	Y145X	taC	taA	1	1	B.1.221.4	0.004167
S	145	Y145D	Tac	Gac	1	1	B.1.234	0.000132
S	145	Y145Y	taC	taT	1	1	B.1.239	0.001221
S	145	Y145Y	taC	taT	1	1	B.1.240.2	0.030303
S	145	Y145H	Tac	Cac	1	1	B.1.258.17	0.000104
S	145	Y145Y	taC	taT	1	1	B.1.258.17	0.000104
S	145	Y145D	Tac	Gac	1	1	B.1.258.22	0.002667
S	145	Y145D	Tac	Gac	1	1	B.1.265	0.001271
S	145	Y145del	TAC	---	1	1	B.1.279	0.000514
S	145	Y145Y	taC	taT	1	1	B.1.3	0.002618
S	145	Y145Y	taC	taT	1	1	B.1.311	0.000275
S	145	Y145N	Tac	Aac	1	1	B.1.326	0.007576
S	145	Y145Y	taC	taT	1	1	B.1.343	0.020833
S	145	Y145H	Tac	Cac	1	1	B.1.351	0.00003
S	145	Y145D	Tac	Gac	1	1	B.1.351.2	0.000303
S	145	Y145H	Tac	Cac	1	1	B.1.36	0.000146
S	145	Y145D	Tac	Gac	1	1	B.1.36	0.000146
S	145	Y145Y	taC	taT	1	1	B.1.36.17	0.000494
S	145	Y145N	Tac	Aac	1	1	B.1.36.27	0.000763
S	145	Y145del	TAC	---	1	1	B.1.36.31	0.001751
S	145	Y145Y	taC	taT	1	1	B.1.360	0.012658
S	145	Y145N	Tac	Aac	1	1	B.1.367	0.000792
S	145	Y145del	TAC	---	1	1	B.1.37	0.014706
S	145	Y145del	TAC	---	1	1	B.1.380	0.006623
S	145	Y145N	Tac	Aac	1	1	B.1.380	0.006623
S	145	Y145del	TAC	---	1	1	B.1.391	0.001127
S	145	Y145Y	taC	taT	1	1	B.1.396	0.000706
S	145	Y145N	Tac	Aac	1	1	B.1.399	0.001934
S	145	Y145Y	taC	taT	1	1	B.1.399	0.001934
S	145	Y145H	Tac	Cac	1	1	B.1.409	0.000781
S	145	Y145del	TAC	---	1	1	B.1.415	0.014286
S	145	Y145del	TAC	---	1	1	B.1.416	0.001269
S	145	Y145N	Tac	Aac	1	1	B.1.427	0.00005
S	145	Y145del	TAC	---	1	1	B.1.427	0.00005
S	145	Y145C	tAC	tGT	1	1	B.1.427	0.00005
S	145	Y145del	TAC	---	1	1	B.1.429	0.000024
S	145	Y145Y	taC	taT	1	1	B.1.433	0.003195
S	145	Y145N	Tac	Aac	1	1	B.1.459	0.004082
S	145	Y145Y	taC	taT	1	1	B.1.459	0.004082
S	145	Y145D	Tac	Gac	1	1	B.1.459	0.004082
S	145	Y145del	TAC	---	1	1	B.1.466.1	0.007194
S	145	Y145Y	taC	taT	1	1	B.1.470	0.001404
S	145	Y145N	Tac	Aac	1	1	B.1.497	0.000315
S	145	Y145Y	taC	taT	1	1	B.1.503	0.002488
S	145	Y145del1	tAC	t-N	1	1	B.1.507	0.011236
S	145	Y145Y	taC	taT	1	1	B.1.523	0.002451
S	145	Y145Y	taC	taT	1	1	B.1.524	0.001406
S	145	Y145H	Tac	Cac	1	1	B.1.525	0.000113
S	145	Y145D	Tac	Gac	1	1	B.1.525	0.000113
S	145	Y145S	tAc	tCc	1	1	B.1.526	0.000024
S	145	Y145N	Tac	Aac	1	1	B.1.526	0.000024
S	145	Y145H	Tac	Cac	1	1	B.1.526	0.000024
S	145	Y145Y	taC	taT	1	1	B.1.527	0.003704
S	145	Y145del	TAC	---	1	1	B.1.565	0.00081
S	145	Y145D	Tac	Gac	1	1	B.1.565	0.00081
S	145	Y145D	Tac	Gac	1	1	B.1.567	0.003333
S	145	Y145del	TAC	---	1	1	B.1.568	0.001111
S	145	Y145Y	taC	taT	1	1	B.1.575	0.000303
S	145	Y145K	TaC	AaA	1	1	B.1.582	0.000491
S	145	Y145del	TAC	---	1	1	B.1.585	0.027778
S	145	Y145D	Tac	Gac	1	1	B.1.587	0.001898
S	145	Y145Y	taC	taT	1	1	B.1.588	0.00091
S	145	Y145H	Tac	Cac	1	1	B.1.596	0.000087
S	145	Y145del	TAC	---	1	1	B.1.596.1	0.009346
S	145	Y145Y	taC	taT	1	1	B.1.597	0.00463
S	145	Y145del	TAC	---	1	1	B.1.612	0.002653
S	145	Y145del2	TAc	--c	1	1	B.1.617.1	0.000129
S	145	Y145F	tAc	tTc	1	1	B.1.617.2	0.000004
S	145	Y145X	taC	taG	1	1	B.1.617.2	0.000004
S	145	Y145C	tAC	tGT	1	1	B.1.617.2	0.000004
S	145	Y145L	TAc	CTc	1	1	B.1.617.2	0.000004
S	145	Y145K	TaC	AaA	1	1	B.1.618	0.004032
S	145	Y145del2	tAC	t--	1	1	B.1.621	0.000089
S	145	Y145I	TAC	ATT	1	1	B.1.621	0.000089
S	145	Y145L	tAC	tTA	1	1	B.1.621.1	0.000506
S	145	Y145Y	taC	taT	1	1	B.1.623	0.000536
S	145	Y145N	Tac	Aac	1	1	B.1.630	0.005236
S	145	Y145E	TaC	GaA	1	1	B.1.637	0.000073
S	145	Y145N	Tac	Aac	1	1	B.1.638	0.052632
S	145	Y145del	TAC	---	1	1	B.1.9.4	0.006135
S	145	Y145del	TAC	---	1	1	B.1.93	0.000934
S	145	Y145Y	taC	taT	1	1	B.11	0.005128
S	145	Y145D	Tac	Gac	1	1	B.31	0.003731
S	145	Y145N	Tac	Aac	1	1	B.4	0.002208
S	145	Y145Y	taC	taT	1	1	B.40	0.000364
S	145	Y145N	Tac	Aac	1	1	B.55	0.00295
S	145	Y145V	TAc	GTc	1	1	B.6	0.00091
S	145	Y145S	tAc	tCc	1	1	B.6	0.00091
S	145	Y145D	Tac	Gac	1	1	C.18	0.002591
S	145	Y145del	TAC	---	1	1	C.36	0.000911
S	145	Y145N	Tac	Aac	1	1	C.37	0.000116
S	145	Y145D	Tac	Gac	1	1	N.10	0.029412
S	145	Y145D	Tac	Gac	1	1	P.1.1	0.000318
S	145	Y145del	TAC	---	1	1	P.1.1	0.000318
S	145	Y145N	Tac	Aac	1	1	P.1.14	0.000048
S	145	Y145H	Tac	Cac	1	1	P.1.14	0.000048
S	145	Y145Y	taC	taT	1	1	P.1.16	0.000374
S	145	Y145D	Tac	Gac	1	1	P.1.17	0.000162
S	145	Y145del	TAC	---	1	1	P.1.17	0.000162
S	145	Y145del	TAC	---	1	1	P.1.2	0.001156
S	145	Y145Y	taC	taT	1	1	P.1.2	0.001156
S	145	Y145del	TAC	---	1	1	P.2	0.000187
S	145	Y145del	TAC	---	1	1	Q.1	0.000126
S	145	Y145del	TAC	---	1	1	Q.7	0.001111
S	145	Y145H	Tac	Cac	1	1	Q.8	0.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.