CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF8 : Mut = R52K

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF8	52	R52K		nonsyn	aGa	aAa	3345	3344	0.999701	28047-28049
ORF8	52	R52K		nonsyn	aGA	aAG	3345	1	0.000298954	28047-28049

Details of the mutation R52K within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF8	52	R52K	aGa	aAa	3344	3345	All	0.00064
ORF8	52	R52K	aGA	aAG	1	3345	All	0
ORF8	52	R52K	aGa	aAa	2675	2675	B.1.628	0.942565
ORF8	52	R52K	aGa	aAa	193	193	AY.25	0.001161
ORF8	52	R52K	aGa	aAa	110	111	B.1.1.7	0.000098
ORF8	52	R52K	aGA	aAG	1	111	B.1.1.7	0.000001
ORF8	52	R52K	aGa	aAa	88	88	B.1	0.000806
ORF8	52	R52K	aGa	aAa	72	72	B.1.1.375	0.857143
ORF8	52	R52K	aGa	aAa	38	38	AY.44	0.000231
ORF8	52	R52K	aGa	aAa	14	14	B.1.627	0.028283
ORF8	52	R52K	aGa	aAa	13	13	AY.43	0.000058
ORF8	52	R52K	aGa	aAa	13	13	B.1.1.319	0.22807
ORF8	52	R52K	aGa	aAa	13	13	C.1.1	1
ORF8	52	R52K	aGa	aAa	12	12	B.1.617.2	0.000045
ORF8	52	R52K	aGa	aAa	8	8	AY.4	0.000012
ORF8	52	R52K	aGa	aAa	8	8	B.1.177.10	0.007024
ORF8	52	R52K	aGa	aAa	6	6	AY.3	0.00006
ORF8	52	R52K	aGa	aAa	6	6	B.1.1	0.000109
ORF8	52	R52K	aGa	aAa	6	6	B.1.258	0.000399
ORF8	52	R52K	aGa	aAa	5	5	P.1.12	0.00242
ORF8	52	R52K	aGa	aAa	4	4	B.1.258.17	0.000416
ORF8	52	R52K	aGa	aAa	3	3	AY.118	0.000188
ORF8	52	R52K	aGa	aAa	3	3	B.1.177	0.00004
ORF8	52	R52K	aGa	aAa	3	3	B.1.429	0.000071
ORF8	52	R52K	aGa	aAa	3	3	D.2	0.000225
ORF8	52	R52K	aGa	aAa	3	3	P.1	0.000047
ORF8	52	R52K	aGa	aAa	3	3	P.1.15	0.000697
ORF8	52	R52K	aGa	aAa	2	2	AY.103	0.000012
ORF8	52	R52K	aGa	aAa	2	2	B.1.2	0.000018
ORF8	52	R52K	aGa	aAa	2	2	B.1.234	0.000264
ORF8	52	R52K	aGa	aAa	2	2	B.1.474	0.003802
ORF8	52	R52K	aGa	aAa	2	2	B.1.596	0.000174
ORF8	52	R52K	aGa	aAa	2	2	C.6	0.074074
ORF8	52	R52K	aGa	aAa	1	1	A.2.5	0.000499
ORF8	52	R52K	aGa	aAa	1	1	AY.100	0.000046
ORF8	52	R52K	aGa	aAa	1	1	AY.111	0.000183
ORF8	52	R52K	aGa	aAa	1	1	AY.121	0.000135
ORF8	52	R52K	aGa	aAa	1	1	AY.19	0.00114
ORF8	52	R52K	aGa	aAa	1	1	AY.39	0.000025
ORF8	52	R52K	aGa	aAa	1	1	AY.45	0.000122
ORF8	52	R52K	aGa	aAa	1	1	AY.66	0.00107
ORF8	52	R52K	aGa	aAa	1	1	AY.71	0.000475
ORF8	52	R52K	aGa	aAa	1	1	AY.73	0.000665
ORF8	52	R52K	aGa	aAa	1	1	AY.98.1	0.000048
ORF8	52	R52K	aGa	aAa	1	1	B.1.1.169	0.018182
ORF8	52	R52K	aGa	aAa	1	1	B.1.1.372	0.000689
ORF8	52	R52K	aGa	aAa	1	1	B.1.1.433	0.001425
ORF8	52	R52K	aGa	aAa	1	1	B.1.1.70	0.000341
ORF8	52	R52K	aGa	aAa	1	1	B.1.110.3	0.000718
ORF8	52	R52K	aGa	aAa	1	1	B.1.177.44	0.000519
ORF8	52	R52K	aGa	aAa	1	1	B.1.177.73	0.000566
ORF8	52	R52K	aGa	aAa	1	1	B.1.237	0.004975
ORF8	52	R52K	aGa	aAa	1	1	B.1.239	0.001221
ORF8	52	R52K	aGa	aAa	1	1	B.1.247	0.014925
ORF8	52	R52K	aGa	aAa	1	1	B.1.351	0.00003
ORF8	52	R52K	aGa	aAa	1	1	B.1.36	0.000146
ORF8	52	R52K	aGa	aAa	1	1	B.1.406	0.006061
ORF8	52	R52K	aGa	aAa	1	1	B.1.526	0.000024
ORF8	52	R52K	aGa	aAa	1	1	B.1.76	0.011364
ORF8	52	R52K	aGa	aAa	1	1	B.46	0.020833
ORF8	52	R52K	aGa	aAa	1	1	C.1	0.002392
ORF8	52	R52K	aGa	aAa	1	1	P.1.13	0.000898
ORF8	52	R52K	aGa	aAa	1	1	P.1.14	0.000048

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.