CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF8 : Mut = E59V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF8	59	E59V		nonsyn	gAa	gTa	49	41	0.836735	28068-28070
ORF8	59	E59V		nonsyn	gAA	gTC	49	4	0.0816327	28068-28070
ORF8	59	E59V		nonsyn	gAA	gTG	49	3	0.0612245	28068-28070
ORF8	59	E59V		nonsyn	gAA	gTT	49	1	0.0204082	28068-28070

Details of the mutation E59V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF8	59	E59V	gAa	gTa	41	49	All	0.000008
ORF8	59	E59V	gAA	gTC	4	49	All	0.000001
ORF8	59	E59V	gAA	gTG	3	49	All	0.000001
ORF8	59	E59V	gAA	gTT	1	49	All	0
ORF8	59	E59V	gAa	gTa	10	10	B.1.1.7	0.000009
ORF8	59	E59V	gAa	gTa	2	4	AY.3	0.00002
ORF8	59	E59V	gAA	gTC	2	4	AY.3	0.00002
ORF8	59	E59V	gAa	gTa	3	4	AY.43	0.000013
ORF8	59	E59V	gAA	gTG	1	4	AY.43	0.000004
ORF8	59	E59V	gAa	gTa	3	3	B.1.258.21	0.023256
ORF8	59	E59V	gAa	gTa	1	2	AY.113	0.000142
ORF8	59	E59V	gAA	gTG	1	2	AY.113	0.000142
ORF8	59	E59V	gAa	gTa	2	2	AY.20	0.000078
ORF8	59	E59V	gAa	gTa	2	2	AY.25	0.000012
ORF8	59	E59V	gAa	gTa	2	2	AY.4	0.000003
ORF8	59	E59V	gAa	gTa	2	2	AY.44	0.000012
ORF8	59	E59V	gAa	gTa	2	2	B.1	0.000018
ORF8	59	E59V	gAA	gTC	1	2	P.1	0.000016
ORF8	59	E59V	gAA	gTT	1	2	P.1	0.000016
ORF8	59	E59V	gAa	gTa	1	1	A.2.5	0.000499
ORF8	59	E59V	gAa	gTa	1	1	AT.1	0.005128
ORF8	59	E59V	gAa	gTa	1	1	AY.120	0.000037
ORF8	59	E59V	gAA	gTC	1	1	AY.9.2	0.000037
ORF8	59	E59V	gAa	gTa	1	1	AY.98.1	0.000048
ORF8	59	E59V	gAa	gTa	1	1	AY.99.2	0.000092
ORF8	59	E59V	gAa	gTa	1	1	AZ.2	0.000821
ORF8	59	E59V	gAa	gTa	1	1	B	0.000128
ORF8	59	E59V	gAA	gTG	1	1	B.1.177.63	0.002703
ORF8	59	E59V	gAa	gTa	1	1	B.1.2	0.000009
ORF8	59	E59V	gAa	gTa	1	1	B.1.311	0.000275
ORF8	59	E59V	gAa	gTa	1	1	B.1.370	0.008
ORF8	59	E59V	gAa	gTa	1	1	B.1.617.2	0.000004
ORF8	59	E59V	gAa	gTa	1	1	B.23	0.002924

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.