CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF8 : Mut = E59D

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF8	59	E59D		nonsyn	gaA	gaC	534	304	0.569288	28068-28070
ORF8	59	E59D		nonsyn	gaA	gaT	534	230	0.430712	28068-28070

Details of the mutation E59D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF8	59	E59D	gaA	gaC	304	534	All	0.000058
ORF8	59	E59D	gaA	gaT	230	534	All	0.000044
ORF8	59	E59D	gaA	gaT	165	165	AY.25	0.000992
ORF8	59	E59D	gaA	gaC	70	98	AY.4	0.000109
ORF8	59	E59D	gaA	gaT	28	98	AY.4	0.000044
ORF8	59	E59D	gaA	gaC	69	69	AY.46.4	0.011351
ORF8	59	E59D	gaA	gaC	60	60	AY.102	0.001591
ORF8	59	E59D	gaA	gaC	14	28	B.1.1.7	0.000013
ORF8	59	E59D	gaA	gaT	14	28	B.1.1.7	0.000013
ORF8	59	E59D	gaA	gaC	15	17	P.1	0.000236
ORF8	59	E59D	gaA	gaT	2	17	P.1	0.000032
ORF8	59	E59D	gaA	gaC	11	14	B.1.617.2	0.000041
ORF8	59	E59D	gaA	gaT	3	14	B.1.617.2	0.000011
ORF8	59	E59D	gaA	gaC	12	13	AY.3	0.000119
ORF8	59	E59D	gaA	gaT	1	13	AY.3	0.00001
ORF8	59	E59D	gaA	gaC	7	8	B.1	0.000064
ORF8	59	E59D	gaA	gaT	1	8	B.1	0.000009
ORF8	59	E59D	gaA	gaC	4	5	B.1.1	0.000073
ORF8	59	E59D	gaA	gaT	1	5	B.1.1	0.000018
ORF8	59	E59D	gaA	gaC	5	5	B.1.1.519	0.000199
ORF8	59	E59D	gaA	gaT	4	5	B.1.177	0.000053
ORF8	59	E59D	gaA	gaC	1	5	B.1.177	0.000013
ORF8	59	E59D	gaA	gaC	4	4	AY.120	0.000149
ORF8	59	E59D	gaA	gaC	4	4	AY.39.1	0.000158
ORF8	59	E59D	gaA	gaC	3	3	AY.103	0.000019
ORF8	59	E59D	gaA	gaC	2	3	AY.39	0.000049
ORF8	59	E59D	gaA	gaT	1	3	AY.39	0.000025
ORF8	59	E59D	gaA	gaC	2	3	AY.4.2	0.000043
ORF8	59	E59D	gaA	gaT	1	3	AY.4.2	0.000022
ORF8	59	E59D	gaA	gaT	3	3	AY.85	0.001282
ORF8	59	E59D	gaA	gaC	2	2		0.111111
ORF8	59	E59D	gaA	gaC	2	2	AY.43	0.000009
ORF8	59	E59D	gaA	gaC	1	2	AY.44	0.000006
ORF8	59	E59D	gaA	gaT	1	2	AY.44	0.000006
ORF8	59	E59D	gaA	gaC	2	2	B.1.497	0.00063
ORF8	59	E59D	gaA	gaC	1	1	AY.1	0.000396
ORF8	59	E59D	gaA	gaC	1	1	AY.117	0.000085
ORF8	59	E59D	gaA	gaT	1	1	AY.32	0.000532
ORF8	59	E59D	gaA	gaC	1	1	AY.47	0.000031
ORF8	59	E59D	gaA	gaC	1	1	AY.70	0.000209
ORF8	59	E59D	gaA	gaC	1	1	AY.9.2	0.000037
ORF8	59	E59D	gaA	gaT	1	1	B.1.1.282	0.011628
ORF8	59	E59D	gaA	gaC	1	1	B.1.1.294	0.001266
ORF8	59	E59D	gaA	gaC	1	1	B.1.177.44	0.000519
ORF8	59	E59D	gaA	gaT	1	1	B.1.177.46	0.000918
ORF8	59	E59D	gaA	gaT	1	1	B.1.2	0.000009
ORF8	59	E59D	gaA	gaC	1	1	B.1.429	0.000024
ORF8	59	E59D	gaA	gaC	1	1	B.1.538	0.008065
ORF8	59	E59D	gaA	gaT	1	1	B.1.596	0.000087
ORF8	59	E59D	gaA	gaC	1	1	P.1.2	0.001156
ORF8	59	E59D	gaA	gaC	1	1	P.2	0.000187
ORF8	59	E59D	gaA	gaC	1	1	Q.2	0.000613
ORF8	59	E59D	gaA	gaC	1	1	Q.4	0.000455
ORF8	59	E59D	gaA	gaC	1	1	Q.8	0.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.