CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF8 : Mut = E59A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF8	59	E59A		nonsyn	gAa	gCa	77	75	0.974026	28068-28070
ORF8	59	E59A		nonsyn	gAA	gCC	77	2	0.025974	28068-28070

Details of the mutation E59A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF8	59	E59A	gAa	gCa	75	77	All	0.000014
ORF8	59	E59A	gAA	gCC	2	77	All	0
ORF8	59	E59A	gAa	gCa	10	10	B.1.2	0.000088
ORF8	59	E59A	gAa	gCa	9	9	AY.4	0.000014
ORF8	59	E59A	gAa	gCa	8	8	P.1.14	0.000382
ORF8	59	E59A	gAa	gCa	7	7	AY.9.2	0.000257
ORF8	59	E59A	gAa	gCa	5	5	AY.103	0.000031
ORF8	59	E59A	gAa	gCa	4	4	AY.75	0.000224
ORF8	59	E59A	gAa	gCa	4	4	AZ.2	0.003284
ORF8	59	E59A	gAa	gCa	3	3	B.1.1.7	0.000003
ORF8	59	E59A	gAa	gCa	3	3	B.1.526	0.000071
ORF8	59	E59A	gAa	gCa	3	3	B.1.617.2	0.000011
ORF8	59	E59A	gAa	gCa	2	2	AY.25	0.000012
ORF8	59	E59A	gAa	gCa	2	2	AY.4.2	0.000043
ORF8	59	E59A	gAa	gCa	2	2	AY.43	0.000009
ORF8	59	E59A	gAa	gCa	2	2	AY.44	0.000012
ORF8	59	E59A	gAa	gCa	1	2	P.1	0.000016
ORF8	59	E59A	gAA	gCC	1	2	P.1	0.000016
ORF8	59	E59A	gAA	gCC	1	2	P.2	0.000187
ORF8	59	E59A	gAa	gCa	1	2	P.2	0.000187
ORF8	59	E59A	gAa	gCa	1	1	AY.110	0.000113
ORF8	59	E59A	gAa	gCa	1	1	AY.23	0.00007
ORF8	59	E59A	gAa	gCa	1	1	AY.5	0.000021
ORF8	59	E59A	gAa	gCa	1	1	AY.6	0.000041
ORF8	59	E59A	gAa	gCa	1	1	AY.61	0.000105
ORF8	59	E59A	gAa	gCa	1	1	AY.62	0.000436
ORF8	59	E59A	gAa	gCa	1	1	B.1.1.1	0.000327
ORF8	59	E59A	gAa	gCa	1	1	B.1.177.86	0.000183
ORF8	59	E59A	gAa	gCa	1	1	B.1.243	0.00007

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.