CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF8 : CodonNum = 59 & Codon = Taa

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF8	59	E59X		nonsyn	Gaa	Taa	1955	1954	0.999488	28068-28070

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF8	59	E59X	Gaa	Taa	1954	1955	All	0.000374
ORF8	59	E59X	Gaa	Taa	504	504	AY.4	0.000784
ORF8	59	E59X	Gaa	Taa	199	199	B.1.1.7	0.000178
ORF8	59	E59X	Gaa	Taa	156	156	B.1.177.86	0.028619
ORF8	59	E59X	Gaa	Taa	149	149	B.1.1.37	0.028737
ORF8	59	E59X	Gaa	Taa	82	82	B.1	0.000751
ORF8	59	E59X	Gaa	Taa	80	80	AY.29	0.001262
ORF8	59	E59X	Gaa	Taa	59	59	AY.9.2	0.002167
ORF8	59	E59X	Gaa	Taa	54	54	B.1.1	0.00098
ORF8	59	E59X	Gaa	Taa	45	45	B.1.617.2	0.000169
ORF8	59	E59X	Gaa	Taa	39	39	B.1.1.519	0.001549
ORF8	59	E59X	Gaa	Taa	38	38	AY.44	0.000231
ORF8	59	E59X	Gaa	Taa	34	34	B.1.289	0.090426
ORF8	59	E59X	Gaa	Taa	31	31	B.1.1.352	0.96875
ORF8	59	E59X	Gaa	Taa	28	28	AY.103	0.000174
ORF8	59	E59X	Gaa	Taa	28	28	AY.43	0.000124
ORF8	59	E59X	Gaa	Taa	28	28	B.1.170	0.12069
ORF8	59	E59X	Gaa	Taa	22	22	AY.9.1	0.001842
ORF8	59	E59X	Gaa	Taa	20	20	B.1.1.337	0.071942
ORF8	59	E59X	Gaa	Taa	20	20	B.1.160	0.000624
ORF8	59	E59X	Gaa	Taa	18	18	B.1.1.447	0.642857
ORF8	59	E59X	Gaa	Taa	14	14	N.5	0.024735
ORF8	59	E59X	Gaa	Taa	13	13	B.1.1.222	0.002652
ORF8	59	E59X	Gaa	Taa	11	11	AY.25	0.000066
ORF8	59	E59X	Gaa	Taa	11	11	B.1.621.1	0.005564
ORF8	59	E59X	Gaa	Taa	11	11	P.1	0.000173
ORF8	59	E59X	Gaa	Taa	9	9	AY.121	0.001218
ORF8	59	E59X	Gaa	Taa	9	9	B.1.517	0.003843
ORF8	59	E59X	Gaa	Taa	8	8	AY.98.1	0.000387
ORF8	59	E59X	Gaa	Taa	7	7	B.1.1.63	0.002701
ORF8	59	E59X	Gaa	Taa	7	7	B.1.2	0.000062
ORF8	59	E59X	Gaa	Taa	7	7	B.1.466.2	0.002739
ORF8	59	E59X	Gaa	Taa	6	6	AY.116	0.001721
ORF8	59	E59X	Gaa	Taa	5	5	AY.119	0.000177
ORF8	59	E59X	Gaa	Taa	5	5	AY.47	0.000156
ORF8	59	E59X	Gaa	Taa	5	5	AY.53	0.001438
ORF8	59	E59X	Gaa	Taa	5	5	AY.98	0.000395
ORF8	59	E59X	Gaa	Taa	5	5	B.1.1.312	0.00956
ORF8	59	E59X	Gaa	Taa	5	5	B.1.526	0.000118
ORF8	59	E59X	Gaa	Taa	5	5	B.1.595	0.001305
ORF8	59	E59X	Gaa	Taa	5	5	C.37	0.00058
ORF8	59	E59X	Gaa	Taa	4	4	AY.23	0.000279
ORF8	59	E59X	Gaa	Taa	4	4	AY.3.1	0.000341
ORF8	59	E59X	Gaa	Taa	4	4	AY.33	0.000267
ORF8	59	E59X	Gaa	Taa	4	4	AY.46	0.000416
ORF8	59	E59X	Gaa	Taa	4	4	B.1.525	0.000453
ORF8	59	E59X	Gaa	Taa	3	3	AY.111	0.000549
ORF8	59	E59X	Gaa	Taa	3	3	AY.117	0.000254
ORF8	59	E59X	Gaa	Taa	3	3	AY.3	0.00003
ORF8	59	E59X	Gaa	Taa	3	3	AY.75	0.000168
ORF8	59	E59X	Gaa	Taa	3	3	AZ.3	0.004559
ORF8	59	E59X	Gaa	Taa	3	3	B.1.1.214	0.000166
ORF8	59	E59X	Gaa	Taa	3	3	B.1.1.291	0.002227
ORF8	59	E59X	Gaa	Taa	3	3	B.1.177	0.00004
ORF8	59	E59X	Gaa	Taa	3	3	B.1.243	0.000209
ORF8	59	E59X	Gaa	Taa	3	3	B.1.9.5	0.017045
ORF8	59	E59X	Gaa	Taa	3	3	P.1.7	0.000958
ORF8	59	E59X	Gaa	Taa	3	3	P.2	0.00056
ORF8	59	E59X	Gaa	Taa	2	2	AY.100	0.000092
ORF8	59	E59X	Gaa	Taa	2	2	AY.102	0.000053
ORF8	59	E59X	Gaa	Taa	2	2	AY.106	0.00067
ORF8	59	E59X	Gaa	Taa	1	2	AY.113	0.000142
ORF8	59	E59X	Gaa	Taa	2	2	AY.19	0.002281
ORF8	59	E59X	Gaa	Taa	2	2	AY.20	0.000078
ORF8	59	E59X	Gaa	Taa	2	2	AY.39	0.000049
ORF8	59	E59X	Gaa	Taa	2	2	AY.45	0.000243
ORF8	59	E59X	Gaa	Taa	2	2	AY.61	0.00021
ORF8	59	E59X	Gaa	Taa	2	2	AY.65	0.001066
ORF8	59	E59X	Gaa	Taa	2	2	AY.92	0.000575
ORF8	59	E59X	Gaa	Taa	2	2	AZ.1	0.001735
ORF8	59	E59X	Gaa	Taa	2	2	B	0.000256
ORF8	59	E59X	Gaa	Taa	2	2	B.1.1.216	0.001781
ORF8	59	E59X	Gaa	Taa	2	2	B.1.1.326	0.003521
ORF8	59	E59X	Gaa	Taa	2	2	B.1.1.409	0.005666
ORF8	59	E59X	Gaa	Taa	2	2	B.1.1.50	0.001358
ORF8	59	E59X	Gaa	Taa	2	2	B.1.177.43	0.002954
ORF8	59	E59X	Gaa	Taa	2	2	B.1.210	0.004264
ORF8	59	E59X	Gaa	Taa	2	2	B.1.258	0.000133
ORF8	59	E59X	Gaa	Taa	2	2	B.1.351	0.000059
ORF8	59	E59X	Gaa	Taa	2	2	B.1.609	0.000959
ORF8	59	E59X	Gaa	Taa	2	2	B.1.617.1	0.000258
ORF8	59	E59X	Gaa	Taa	2	2	B.1.621	0.000177
ORF8	59	E59X	Gaa	Taa	2	2	B.6	0.00182
ORF8	59	E59X	Gaa	Taa	2	2	C.36	0.001821
ORF8	59	E59X	Gaa	Taa	1	1	A	0.000387
ORF8	59	E59X	Gaa	Taa	1	1	A.1	0.000282
ORF8	59	E59X	Gaa	Taa	1	1	AD.2	0.000219
ORF8	59	E59X	Gaa	Taa	1	1	AY.118	0.000063
ORF8	59	E59X	Gaa	Taa	1	1	AY.120	0.000037
ORF8	59	E59X	Gaa	Taa	1	1	AY.16	0.00038
ORF8	59	E59X	Gaa	Taa	1	1	AY.16.1	0.00047
ORF8	59	E59X	Gaa	Taa	1	1	AY.26	0.000028
ORF8	59	E59X	Gaa	Taa	1	1	AY.27	0.000065
ORF8	59	E59X	Gaa	Taa	1	1	AY.29.1	0.000221
ORF8	59	E59X	Gaa	Taa	1	1	AY.36	0.000148
ORF8	59	E59X	Gaa	Taa	1	1	AY.38	0.000499
ORF8	59	E59X	Gaa	Taa	1	1	AY.4.4	0.000409
ORF8	59	E59X	Gaa	Taa	1	1	AY.41	0.000294
ORF8	59	E59X	Gaa	Taa	1	1	AY.42	0.00004
ORF8	59	E59X	Gaa	Taa	1	1	AY.46.1	0.001027
ORF8	59	E59X	Gaa	Taa	1	1	AY.46.2	0.000635
ORF8	59	E59X	Gaa	Taa	1	1	AY.46.6	0.000072
ORF8	59	E59X	Gaa	Taa	1	1	AY.5.4	0.000277
ORF8	59	E59X	Gaa	Taa	1	1	AY.6	0.000041
ORF8	59	E59X	Gaa	Taa	1	1	AY.67	0.000464
ORF8	59	E59X	Gaa	Taa	1	1	AY.7.1	0.000113
ORF8	59	E59X	Gaa	Taa	1	1	AY.70	0.000209
ORF8	59	E59X	Gaa	Taa	1	1	AY.9	0.000068
ORF8	59	E59X	Gaa	Taa	1	1	AY.90	0.000684
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.189	0.001513
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.205	0.003717
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.25	0.000569
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.28	0.000311
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.286	0.002899
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.33	0.000421
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.433	0.001425
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.484	0.1
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.52	0.012195
ORF8	59	E59X	Gaa	Taa	1	1	B.1.1.526	0.003546
ORF8	59	E59X	Gaa	Taa	1	1	B.1.111	0.001175
ORF8	59	E59X	Gaa	Taa	1	1	B.1.177.7	0.000165
ORF8	59	E59X	Gaa	Taa	1	1	B.1.177.73	0.000566
ORF8	59	E59X	Gaa	Taa	1	1	B.1.221	0.000071
ORF8	59	E59X	Gaa	Taa	1	1	B.1.340	0.004292
ORF8	59	E59X	Gaa	Taa	1	1	B.1.36	0.000146
ORF8	59	E59X	Gaa	Taa	1	1	B.1.36.17	0.000494
ORF8	59	E59X	Gaa	Taa	1	1	B.1.369	0.000285
ORF8	59	E59X	Gaa	Taa	1	1	B.1.411	0.003704
ORF8	59	E59X	Gaa	Taa	1	1	B.1.428	0.00102
ORF8	59	E59X	Gaa	Taa	1	1	B.1.429	0.000024
ORF8	59	E59X	Gaa	Taa	1	1	B.1.446	0.02
ORF8	59	E59X	Gaa	Taa	1	1	B.1.453	0.003236
ORF8	59	E59X	Gaa	Taa	1	1	B.1.480	0.002488
ORF8	59	E59X	Gaa	Taa	1	1	B.1.499	0.00105
ORF8	59	E59X	Gaa	Taa	1	1	B.1.503	0.002488
ORF8	59	E59X	Gaa	Taa	1	1	B.1.509	0.000866
ORF8	59	E59X	Gaa	Taa	1	1	B.1.560	0.00463
ORF8	59	E59X	Gaa	Taa	1	1	B.1.561	0.000397
ORF8	59	E59X	Gaa	Taa	1	1	B.1.580	0.004065
ORF8	59	E59X	Gaa	Taa	1	1	B.1.596	0.000087
ORF8	59	E59X	Gaa	Taa	1	1	B.1.625	0.002353
ORF8	59	E59X	Gaa	Taa	1	1	B.6.6	0.000889
ORF8	59	E59X	Gaa	Taa	1	1	P.1.14	0.000048
ORF8	59	E59X	Gaa	Taa	1	1	Q.4	0.000455

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.