CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF7b : Mut = H37L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF7b	37	H37L		nonsyn	cAT	cTA	1740	1579	0.907471	27864-27866
ORF7b	37	H37L		nonsyn	cAt	cTt	1740	159	0.0913793	27864-27866
ORF7b	37	H37L		nonsyn	cAT	cTG	1740	2	0.00114943	27864-27866

Details of the mutation H37L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF7b	37	H37L	cAT	cTA	1579	1740	All	0.000302
ORF7b	37	H37L	cAt	cTt	159	1740	All	0.00003
ORF7b	37	H37L	cAT	cTG	2	1740	All	0
ORF7b	37	H37L	cAT	cTA	1285	1293	B.1.1	0.023311
ORF7b	37	H37L	cAt	cTt	6	1293	B.1.1	0.000109
ORF7b	37	H37L	cAT	cTG	2	1293	B.1.1	0.000036
ORF7b	37	H37L	cAT	cTA	73	80	B.1.1.7	0.000065
ORF7b	37	H37L	cAt	cTt	7	80	B.1.1.7	0.000006
ORF7b	37	H37L	cAt	cTt	54	58	AY.47	0.00168
ORF7b	37	H37L	cAT	cTA	4	58	AY.47	0.000124
ORF7b	37	H37L	cAT	cTA	24	34	B.1	0.00022
ORF7b	37	H37L	cAt	cTt	10	34	B.1	0.000092
ORF7b	37	H37L	cAT	cTA	32	32	B.1.160	0.000998
ORF7b	37	H37L	cAt	cTt	13	25	B.1.526	0.000306
ORF7b	37	H37L	cAT	cTA	12	25	B.1.526	0.000282
ORF7b	37	H37L	cAT	cTA	11	20	B.1.1.37	0.002122
ORF7b	37	H37L	cAt	cTt	9	20	B.1.1.37	0.001736
ORF7b	37	H37L	cAT	cTA	19	19	B.1.433	0.060703
ORF7b	37	H37L	cAT	cTA	14	18	B.1.617.2	0.000053
ORF7b	37	H37L	cAt	cTt	4	18	B.1.617.2	0.000015
ORF7b	37	H37L	cAT	cTA	14	14	G.1	0.583333
ORF7b	37	H37L	cAT	cTA	11	11	B.1.617.1	0.001419
ORF7b	37	H37L	cAt	cTt	7	7	AY.4	0.000011
ORF7b	37	H37L	cAT	cTA	4	7	B.1.177	0.000053
ORF7b	37	H37L	cAt	cTt	3	7	B.1.177	0.00004
ORF7b	37	H37L	cAT	cTA	7	7	B.1.575.1	0.017073
ORF7b	37	H37L	cAT	cTA	4	5	B.1.258	0.000266
ORF7b	37	H37L	cAt	cTt	1	5	B.1.258	0.000067
ORF7b	37	H37L	cAt	cTt	3	5	B.1.427	0.000151
ORF7b	37	H37L	cAT	cTA	2	5	B.1.427	0.000101
ORF7b	37	H37L	cAT	cTA	4	4	AY.53	0.00115
ORF7b	37	H37L	cAt	cTt	4	4	B.1.1.317	0.001647
ORF7b	37	H37L	cAt	cTt	3	4	P.1	0.000047
ORF7b	37	H37L	cAT	cTA	1	4	P.1	0.000016
ORF7b	37	H37L	cAt	cTt	3	3	A.2.3	0.014218
ORF7b	37	H37L	cAT	cTA	3	3	AY.16.1	0.00141
ORF7b	37	H37L	cAT	cTA	3	3	AY.65	0.001599
ORF7b	37	H37L	cAT	cTA	3	3	B.1.2	0.000026
ORF7b	37	H37L	cAT	cTA	2	3	B.1.351	0.000059
ORF7b	37	H37L	cAt	cTt	1	3	B.1.351	0.00003
ORF7b	37	H37L	cAt	cTt	3	3	B.1.470	0.004213
ORF7b	37	H37L	cAT	cTA	3	3	B.1.575	0.00091
ORF7b	37	H37L	cAt	cTt	1	2	AY.75	0.000056
ORF7b	37	H37L	cAT	cTA	1	2	AY.75	0.000056
ORF7b	37	H37L	cAT	cTA	1	2	B.1.1.265	0.003155
ORF7b	37	H37L	cAt	cTt	1	2	B.1.1.265	0.003155
ORF7b	37	H37L	cAt	cTt	2	2	B.1.1.318	0.000604
ORF7b	37	H37L	cAT	cTA	2	2	B.1.1.409	0.005666
ORF7b	37	H37L	cAT	cTA	2	2	B.1.1.440	0.023529
ORF7b	37	H37L	cAT	cTA	1	2	B.1.110.3	0.000718
ORF7b	37	H37L	cAt	cTt	1	2	B.1.110.3	0.000718
ORF7b	37	H37L	cAT	cTA	2	2	B.1.111	0.00235
ORF7b	37	H37L	cAt	cTt	1	2	B.1.177.7	0.000165
ORF7b	37	H37L	cAT	cTA	1	2	B.1.177.7	0.000165
ORF7b	37	H37L	cAt	cTt	1	2	B.1.243	0.00007
ORF7b	37	H37L	cAT	cTA	1	2	B.1.243	0.00007
ORF7b	37	H37L	cAT	cTA	1	2	B.1.279	0.000514
ORF7b	37	H37L	cAt	cTt	1	2	B.1.279	0.000514
ORF7b	37	H37L	cAt	cTt	1	2	B.1.36.39	0.002217
ORF7b	37	H37L	cAT	cTA	1	2	B.1.36.39	0.002217
ORF7b	37	H37L	cAT	cTA	2	2	B.1.466.2	0.000782
ORF7b	37	H37L	cAt	cTt	2	2	B.1.568	0.002222
ORF7b	37	H37L	cAt	cTt	1	2	B.1.609	0.000479
ORF7b	37	H37L	cAT	cTA	1	2	B.1.609	0.000479
ORF7b	37	H37L	cAT	cTA	2	2	B.1.623	0.001073
ORF7b	37	H37L	cAt	cTt	2	2	B.1.9.5	0.011364
ORF7b	37	H37L	cAT	cTA	1	1	A.2	0.000662
ORF7b	37	H37L	cAT	cTA	1	1	A.5	0.001923
ORF7b	37	H37L	cAT	cTA	1	1	AD.2	0.000219
ORF7b	37	H37L	cAt	cTt	1	1	AY.102	0.000027
ORF7b	37	H37L	cAt	cTt	1	1	AY.103	0.000006
ORF7b	37	H37L	cAt	cTt	1	1	AY.16	0.00038
ORF7b	37	H37L	cAT	cTA	1	1	AY.26	0.000028
ORF7b	37	H37L	cAt	cTt	1	1	AY.29	0.000016
ORF7b	37	H37L	cAT	cTA	1	1	AY.38	0.000499
ORF7b	37	H37L	cAt	cTt	1	1	AY.43	0.000004
ORF7b	37	H37L	cAT	cTA	1	1	AY.54	0.000095
ORF7b	37	H37L	cAt	cTt	1	1	AY.6	0.000041
ORF7b	37	H37L	cAt	cTt	1	1	AY.61	0.000105
ORF7b	37	H37L	cAT	cTA	1	1	AY.9.2	0.000037
ORF7b	37	H37L	cAT	cTA	1	1	B.1.1.232	0.001815
ORF7b	37	H37L	cAT	cTA	1	1	B.1.1.28	0.000311
ORF7b	37	H37L	cAT	cTA	1	1	B.1.1.286	0.002899
ORF7b	37	H37L	cAt	cTt	1	1	B.1.1.306	0.000438
ORF7b	37	H37L	cAT	cTA	1	1	B.1.1.51	0.001718
ORF7b	37	H37L	cAt	cTt	1	1	B.1.1.519	0.00004
ORF7b	37	H37L	cAt	cTt	1	1	B.1.1.54	0.003021
ORF7b	37	H37L	cAT	cTA	1	1	B.1.1.70	0.000341
ORF7b	37	H37L	cAT	cTA	1	1	B.1.108	0.005814
ORF7b	37	H37L	cAT	cTA	1	1	B.1.177.12	0.000152
ORF7b	37	H37L	cAT	cTA	1	1	B.1.177.17	0.000821
ORF7b	37	H37L	cAt	cTt	1	1	B.1.177.63	0.002703
ORF7b	37	H37L	cAT	cTA	1	1	B.1.177.72	0.00339
ORF7b	37	H37L	cAT	cTA	1	1	B.1.177.83	0.001481
ORF7b	37	H37L	cAT	cTA	1	1	B.1.214	0.003663
ORF7b	37	H37L	cAT	cTA	1	1	B.1.232	0.000537
ORF7b	37	H37L	cAT	cTA	1	1	B.1.258.17	0.000104
ORF7b	37	H37L	cAT	cTA	1	1	B.1.264	0.012346
ORF7b	37	H37L	cAt	cTt	1	1	B.1.311	0.000275
ORF7b	37	H37L	cAT	cTA	1	1	B.1.356	0.001727
ORF7b	37	H37L	cAT	cTA	1	1	B.1.36.29	0.000517
ORF7b	37	H37L	cAt	cTt	1	1	B.1.565	0.00081
ORF7b	37	H37L	cAt	cTt	1	1	C.1.2	0.004255
ORF7b	37	H37L	cAT	cTA	1	1	C.37	0.000116
ORF7b	37	H37L	cAT	cTA	1	1	D.2	0.000075
ORF7b	37	H37L	cAT	cTA	1	1	Q.8	0.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.