CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF7b : Mut = E33Q

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF7b	33	E33Q		nonsyn	Gaa	Caa	32	30	0.9375	27852-27854
ORF7b	33	E33Q		nonsyn	GaA	CaG	32	2	0.0625	27852-27854

Details of the mutation E33Q within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF7b	33	E33Q	Gaa	Caa	30	32	All	0.000006
ORF7b	33	E33Q	GaA	CaG	2	32	All	0
ORF7b	33	E33Q	Gaa	Caa	13	13	AY.103	0.000081
ORF7b	33	E33Q	Gaa	Caa	4	5	B.1.617.2	0.000015
ORF7b	33	E33Q	GaA	CaG	1	5	B.1.617.2	0.000004
ORF7b	33	E33Q	Gaa	Caa	3	3	B.1.1.7	0.000003
ORF7b	33	E33Q	Gaa	Caa	1	1	AY.16.1	0.00047
ORF7b	33	E33Q	GaA	CaG	1	1	AY.3	0.00001
ORF7b	33	E33Q	Gaa	Caa	1	1	AY.47	0.000031
ORF7b	33	E33Q	Gaa	Caa	1	1	AY.61	0.000105
ORF7b	33	E33Q	Gaa	Caa	1	1	B	0.000128
ORF7b	33	E33Q	Gaa	Caa	1	1	B.1	0.000009
ORF7b	33	E33Q	Gaa	Caa	1	1	B.1.1.519	0.00004
ORF7b	33	E33Q	Gaa	Caa	1	1	B.1.258.14	0.00098
ORF7b	33	E33Q	Gaa	Caa	1	1	B.1.605	0.005952
ORF7b	33	E33Q	Gaa	Caa	1	1	D.2	0.000075
ORF7b	33	E33Q	Gaa	Caa	1	1	Q.3	0.000145

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.