CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF7b : Mut = E33D

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF7b	33	E33D		nonsyn	gaA	gaT	27	19	0.703704	27852-27854
ORF7b	33	E33D		nonsyn	gaA	gaC	27	8	0.296296	27852-27854

Details of the mutation E33D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF7b	33	E33D	gaA	gaT	19	27	All	0.000004
ORF7b	33	E33D	gaA	gaC	8	27	All	0.000002
ORF7b	33	E33D	gaA	gaT	9	9	P.1	0.000142
ORF7b	33	E33D	gaA	gaC	4	5	B.1.1.7	0.000004
ORF7b	33	E33D	gaA	gaT	1	5	B.1.1.7	0.000001
ORF7b	33	E33D	gaA	gaT	5	5	B.1.526	0.000118
ORF7b	33	E33D	gaA	gaC	2	2	B.1	0.000018
ORF7b	33	E33D	gaA	gaT	2	2	P.1.17	0.000324
ORF7b	33	E33D	gaA	gaC	1	1	AY.39.1	0.00004
ORF7b	33	E33D	gaA	gaC	1	1	AY.78	0.001541
ORF7b	33	E33D	gaA	gaT	1	1	B.1.1.33	0.000421
ORF7b	33	E33D	gaA	gaT	1	1	B.1.258	0.000067

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.