CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF7a : Mut = A105L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF7a	105	A105L		nonsyn	GCg	TTg	27	23	0.851852	27706-27708
ORF7a	105	A105L		nonsyn	GCG	CTT	27	3	0.111111	27706-27708
ORF7a	105	A105L		nonsyn	GCG	TTA	27	1	0.037037	27706-27708

Details of the mutation A105L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF7a	105	A105L	GCg	TTg	23	27	All	0.000004
ORF7a	105	A105L	GCG	CTT	3	27	All	0.000001
ORF7a	105	A105L	GCG	TTA	1	27	All	0
ORF7a	105	A105L	GCg	TTg	18	18	A.2.5.2	0.028302
ORF7a	105	A105L	GCg	TTg	2	2	AY.61	0.00021
ORF7a	105	A105L	GCg	TTg	1	1	AY.26	0.000028
ORF7a	105	A105L	GCg	TTg	1	1	AY.98.1	0.000048
ORF7a	105	A105L	GCG	CTT	1	1	B.1.1	0.000018
ORF7a	105	A105L	GCG	CTT	1	1	B.1.1.305	0.003861
ORF7a	105	A105L	GCG	TTA	1	1	B.1.416	0.001269
ORF7a	105	A105L	GCG	CTT	1	1	B.1.497	0.000315
ORF7a	105	A105L	GCg	TTg	1	1	B.1.612	0.002653

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.