CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF6 : Mut = Y49H

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF6	49	Y49H		nonsyn	Tat	Cat	2500	2497	0.9988	27346-27348
ORF6	49	Y49H		nonsyn	TaT	CaC	2500	3	0.0012	27346-27348

Details of the mutation Y49H within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF6	49	Y49H	Tat	Cat	2497	2500	All	0.000478
ORF6	49	Y49H	TaT	CaC	3	2500	All	0.000001
ORF6	49	Y49H	Tat	Cat	895	895	AY.4	0.001393
ORF6	49	Y49H	Tat	Cat	460	460	AY.77	0.518602
ORF6	49	Y49H	Tat	Cat	291	291	B.1.1.7	0.000261
ORF6	49	Y49H	Tat	Cat	166	166	AY.3	0.001651
ORF6	49	Y49H	Tat	Cat	121	121	B.1.617.2	0.000456
ORF6	49	Y49H	Tat	Cat	46	46	AY.46	0.004788
ORF6	49	Y49H	Tat	Cat	32	32	AY.25	0.000192
ORF6	49	Y49H	Tat	Cat	29	29	AY.44	0.000177
ORF6	49	Y49H	Tat	Cat	25	25	AY.101	0.012261
ORF6	49	Y49H	Tat	Cat	23	23	AY.43	0.000102
ORF6	49	Y49H	Tat	Cat	23	23	B.1.2	0.000203
ORF6	49	Y49H	Tat	Cat	22	22	AY.75.1	0.003967
ORF6	49	Y49H	Tat	Cat	22	22	B.1.177	0.00029
ORF6	49	Y49H	Tat	Cat	19	19	AY.102	0.000504
ORF6	49	Y49H	Tat	Cat	16	16	AY.9.2	0.000588
ORF6	49	Y49H	Tat	Cat	14	14	AY.100	0.000644
ORF6	49	Y49H	Tat	Cat	12	13	B.1	0.00011
ORF6	49	Y49H	TaT	CaC	1	13	B.1	0.000009
ORF6	49	Y49H	Tat	Cat	13	13	P.1	0.000205
ORF6	49	Y49H	Tat	Cat	11	11	B.1.1.519	0.000437
ORF6	49	Y49H	Tat	Cat	11	11	B.1.525	0.001245
ORF6	49	Y49H	Tat	Cat	10	10	AY.103	0.000062
ORF6	49	Y49H	Tat	Cat	10	10	B.1.36	0.001459
ORF6	49	Y49H	Tat	Cat	9	9	AY.29.1	0.001985
ORF6	49	Y49H	Tat	Cat	9	9	B.1.1.216	0.008014
ORF6	49	Y49H	Tat	Cat	8	8	AY.114	0.001849
ORF6	49	Y49H	Tat	Cat	8	8	B.1.1.434	0.002788
ORF6	49	Y49H	Tat	Cat	7	7	AY.20	0.000272
ORF6	49	Y49H	Tat	Cat	7	7	AY.26	0.000198
ORF6	49	Y49H	Tat	Cat	7	7	AY.29	0.00011
ORF6	49	Y49H	Tat	Cat	7	7	B.1.526	0.000165
ORF6	49	Y49H	Tat	Cat	7	7	Q.1	0.000884
ORF6	49	Y49H	Tat	Cat	6	6	AY.39	0.000148
ORF6	49	Y49H	Tat	Cat	6	6	B.1.1	0.000109
ORF6	49	Y49H	Tat	Cat	6	6	B.1.160	0.000187
ORF6	49	Y49H	Tat	Cat	5	5	AY.113	0.000712
ORF6	49	Y49H	Tat	Cat	5	5	AY.67	0.002321
ORF6	49	Y49H	Tat	Cat	5	5	AY.9.1	0.000419
ORF6	49	Y49H	Tat	Cat	5	5	B.1.1.153	0.005476
ORF6	49	Y49H	Tat	Cat	5	5	R.1	0.00045
ORF6	49	Y49H	Tat	Cat	4	4	A	0.001548
ORF6	49	Y49H	Tat	Cat	4	4	AY.4.4	0.001637
ORF6	49	Y49H	Tat	Cat	4	4	AY.45	0.000487
ORF6	49	Y49H	Tat	Cat	4	4	AY.47	0.000124
ORF6	49	Y49H	Tat	Cat	4	4	B.1.596	0.000349
ORF6	49	Y49H	Tat	Cat	3	3	AY.119	0.000106
ORF6	49	Y49H	Tat	Cat	3	3	AY.120	0.000112
ORF6	49	Y49H	Tat	Cat	3	3	AY.3.1	0.000256
ORF6	49	Y49H	Tat	Cat	3	3	AY.33	0.0002
ORF6	49	Y49H	Tat	Cat	3	3	AY.46.5	0.000595
ORF6	49	Y49H	Tat	Cat	3	3	AY.46.6	0.000217
ORF6	49	Y49H	Tat	Cat	3	3	AY.59	0.001589
ORF6	49	Y49H	Tat	Cat	3	3	AY.75	0.000168
ORF6	49	Y49H	TaT	CaC	2	2		0.111111
ORF6	49	Y49H	Tat	Cat	2	2	AY.1	0.000791
ORF6	49	Y49H	Tat	Cat	2	2	AY.118	0.000125
ORF6	49	Y49H	Tat	Cat	2	2	AY.23	0.000139
ORF6	49	Y49H	Tat	Cat	2	2	AY.46.1	0.002053
ORF6	49	Y49H	Tat	Cat	2	2	AY.5	0.000041
ORF6	49	Y49H	Tat	Cat	2	2	AY.6	0.000082
ORF6	49	Y49H	Tat	Cat	2	2	AY.66	0.002139
ORF6	49	Y49H	Tat	Cat	2	2	AY.73	0.001331
ORF6	49	Y49H	Tat	Cat	2	2	AY.99.2	0.000184
ORF6	49	Y49H	Tat	Cat	2	2	B.1.160.8	0.002577
ORF6	49	Y49H	Tat	Cat	2	2	B.1.36.29	0.001035
ORF6	49	Y49H	Tat	Cat	2	2	B.1.523	0.004902
ORF6	49	Y49H	Tat	Cat	1	1	A.2.5.2	0.001572
ORF6	49	Y49H	Tat	Cat	1	1	AT.1	0.005128
ORF6	49	Y49H	Tat	Cat	1	1	AY.105	0.000643
ORF6	49	Y49H	Tat	Cat	1	1	AY.111	0.000183
ORF6	49	Y49H	Tat	Cat	1	1	AY.117	0.000085
ORF6	49	Y49H	Tat	Cat	1	1	AY.121	0.000135
ORF6	49	Y49H	Tat	Cat	1	1	AY.28	0.00189
ORF6	49	Y49H	Tat	Cat	1	1	AY.34	0.000097
ORF6	49	Y49H	Tat	Cat	1	1	AY.36	0.000148
ORF6	49	Y49H	Tat	Cat	1	1	AY.39.1	0.00004
ORF6	49	Y49H	Tat	Cat	1	1	AY.4.2	0.000022
ORF6	49	Y49H	Tat	Cat	1	1	AY.42	0.00004
ORF6	49	Y49H	Tat	Cat	1	1	AY.5.3	0.000337
ORF6	49	Y49H	Tat	Cat	1	1	AY.53	0.000288
ORF6	49	Y49H	Tat	Cat	1	1	AY.54	0.000095
ORF6	49	Y49H	Tat	Cat	1	1	AY.60	0.000938
ORF6	49	Y49H	Tat	Cat	1	1	AY.7.1	0.000113
ORF6	49	Y49H	Tat	Cat	1	1	AY.71	0.000475
ORF6	49	Y49H	Tat	Cat	1	1	B.1.1.28	0.000311
ORF6	49	Y49H	Tat	Cat	1	1	B.1.1.284	0.000107
ORF6	49	Y49H	Tat	Cat	1	1	B.1.1.294	0.001266
ORF6	49	Y49H	Tat	Cat	1	1	B.1.1.37	0.000193
ORF6	49	Y49H	Tat	Cat	1	1	B.1.1.39	0.00051
ORF6	49	Y49H	Tat	Cat	1	1	B.1.177.56	0.000668
ORF6	49	Y49H	Tat	Cat	1	1	B.1.177.83	0.001481
ORF6	49	Y49H	Tat	Cat	1	1	B.1.234	0.000132
ORF6	49	Y49H	Tat	Cat	1	1	B.1.265	0.001271
ORF6	49	Y49H	Tat	Cat	1	1	B.1.351	0.00003
ORF6	49	Y49H	Tat	Cat	1	1	B.1.351.3	0.000876
ORF6	49	Y49H	Tat	Cat	1	1	B.1.36.18	0.00042
ORF6	49	Y49H	Tat	Cat	1	1	B.1.428	0.00102
ORF6	49	Y49H	Tat	Cat	1	1	B.1.429	0.000024
ORF6	49	Y49H	Tat	Cat	1	1	B.1.510	0.026316
ORF6	49	Y49H	Tat	Cat	1	1	B.1.575	0.000303
ORF6	49	Y49H	Tat	Cat	1	1	B.1.605	0.005952
ORF6	49	Y49H	Tat	Cat	1	1	B.1.621	0.000089
ORF6	49	Y49H	Tat	Cat	1	1	B.1.625	0.002353
ORF6	49	Y49H	Tat	Cat	1	1	B.1.628	0.000352
ORF6	49	Y49H	Tat	Cat	1	1	B.4	0.002208
ORF6	49	Y49H	Tat	Cat	1	1	C.30.1	0.006711
ORF6	49	Y49H	Tat	Cat	1	1	C.36.3	0.000567
ORF6	49	Y49H	Tat	Cat	1	1	C.37	0.000116
ORF6	49	Y49H	Tat	Cat	1	1	C.4	0.01
ORF6	49	Y49H	Tat	Cat	1	1	P.1.14	0.000048
ORF6	49	Y49H	Tat	Cat	1	1	P.1.7	0.000319
ORF6	49	Y49H	Tat	Cat	1	1	P.2	0.000187

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.