CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF6 : Mut = D61V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF6	61	D61V		nonsyn	gAt	gTt	355	213	0.6	27382-27384
ORF6	61	D61V		nonsyn	gAT	gTC	355	137	0.385915	27382-27384
ORF6	61	D61V		nonsyn	gAT	gTA	355	5	0.0140845	27382-27384

Details of the mutation D61V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF6	61	D61V	gAt	gTt	213	355	All	0.000041
ORF6	61	D61V	gAT	gTC	137	355	All	0.000026
ORF6	61	D61V	gAT	gTA	5	355	All	0.000001
ORF6	61	D61V	gAt	gTt	60	92	B.1.1.7	0.000054
ORF6	61	D61V	gAT	gTC	32	92	B.1.1.7	0.000029
ORF6	61	D61V	gAt	gTt	20	33	AY.4	0.000031
ORF6	61	D61V	gAT	gTC	13	33	AY.4	0.00002
ORF6	61	D61V	gAT	gTC	11	22	B.1	0.000101
ORF6	61	D61V	gAt	gTt	11	22	B.1	0.000101
ORF6	61	D61V	gAt	gTt	8	12	B.1.2	0.00007
ORF6	61	D61V	gAT	gTC	4	12	B.1.2	0.000035
ORF6	61	D61V	gAT	gTC	10	12	B.1.617.2	0.000038
ORF6	61	D61V	gAt	gTt	2	12	B.1.617.2	0.000008
ORF6	61	D61V	gAt	gTt	7	9	AY.85	0.00299
ORF6	61	D61V	gAT	gTC	2	9	AY.85	0.000854
ORF6	61	D61V	gAt	gTt	4	8	B.1.1.279	0.004484
ORF6	61	D61V	gAT	gTC	4	8	B.1.1.279	0.004484
ORF6	61	D61V	gAt	gTt	4	6	AY.101	0.001962
ORF6	61	D61V	gAT	gTA	2	6	AY.101	0.000981
ORF6	61	D61V	gAt	gTt	5	6	AY.25	0.00003
ORF6	61	D61V	gAT	gTC	1	6	AY.25	0.000006
ORF6	61	D61V	gAt	gTt	6	6	AY.42	0.000241
ORF6	61	D61V	gAt	gTt	3	6	B.1.177	0.00004
ORF6	61	D61V	gAT	gTC	3	6	B.1.177	0.00004
ORF6	61	D61V	gAt	gTt	4	6	P.1	0.000063
ORF6	61	D61V	gAT	gTA	1	6	P.1	0.000016
ORF6	61	D61V	gAT	gTC	1	6	P.1	0.000016
ORF6	61	D61V	gAT	gTC	5	5	AY.100	0.00023
ORF6	61	D61V	gAt	gTt	3	5	B.1.1	0.000054
ORF6	61	D61V	gAT	gTC	2	5	B.1.1	0.000036
ORF6	61	D61V	gAT	gTC	3	4	AY.121	0.000406
ORF6	61	D61V	gAt	gTt	1	4	AY.121	0.000135
ORF6	61	D61V	gAt	gTt	2	4	AY.3	0.00002
ORF6	61	D61V	gAT	gTC	2	4	AY.3	0.00002
ORF6	61	D61V	gAt	gTt	3	4	AY.43	0.000013
ORF6	61	D61V	gAT	gTC	1	4	AY.43	0.000004
ORF6	61	D61V	gAT	gTC	2	4	AY.75	0.000112
ORF6	61	D61V	gAt	gTt	2	4	AY.75	0.000112
ORF6	61	D61V	gAt	gTt	3	4	B.1.637	0.000219
ORF6	61	D61V	gAT	gTC	1	4	B.1.637	0.000073
ORF6	61	D61V	gAT	gTC	2	4	C.37	0.000232
ORF6	61	D61V	gAt	gTt	2	4	C.37	0.000232
ORF6	61	D61V	gAT	gTC	4	4	Q.4	0.001819
ORF6	61	D61V	gAt	gTt	2	3	AY.117	0.000169
ORF6	61	D61V	gAT	gTC	1	3	AY.117	0.000085
ORF6	61	D61V	gAt	gTt	2	3	AY.61	0.00021
ORF6	61	D61V	gAT	gTC	1	3	AY.61	0.000105
ORF6	61	D61V	gAt	gTt	3	3	B.1.258.17	0.000312
ORF6	61	D61V	gAT	gTC	2	2		0.111111
ORF6	61	D61V	gAt	gTt	1	2	A.2.5.2	0.001572
ORF6	61	D61V	gAT	gTC	1	2	A.2.5.2	0.001572
ORF6	61	D61V	gAT	gTC	1	2	AY.113	0.000142
ORF6	61	D61V	gAt	gTt	1	2	AY.113	0.000142
ORF6	61	D61V	gAt	gTt	2	2	AY.20	0.000078
ORF6	61	D61V	gAt	gTt	1	2	AY.23.1	0.000417
ORF6	61	D61V	gAT	gTC	1	2	AY.23.1	0.000417
ORF6	61	D61V	gAT	gTC	1	2	AY.44	0.000006
ORF6	61	D61V	gAt	gTt	1	2	AY.44	0.000006
ORF6	61	D61V	gAT	gTC	1	2	AY.5	0.000021
ORF6	61	D61V	gAt	gTt	1	2	AY.5	0.000021
ORF6	61	D61V	gAt	gTt	1	2	AY.54	0.000095
ORF6	61	D61V	gAT	gTC	1	2	AY.54	0.000095
ORF6	61	D61V	gAt	gTt	1	2	AY.68	0.000274
ORF6	61	D61V	gAT	gTC	1	2	AY.68	0.000274
ORF6	61	D61V	gAT	gTC	1	2	AY.94	0.000443
ORF6	61	D61V	gAt	gTt	1	2	AY.94	0.000443
ORF6	61	D61V	gAt	gTt	1	2	AY.98.1	0.000048
ORF6	61	D61V	gAT	gTC	1	2	AY.98.1	0.000048
ORF6	61	D61V	gAt	gTt	2	2	B.1.1.207	0.002364
ORF6	61	D61V	gAT	gTC	1	2	B.1.1.306	0.000438
ORF6	61	D61V	gAt	gTt	1	2	B.1.1.306	0.000438
ORF6	61	D61V	gAt	gTt	1	2	B.1.1.311	0.000358
ORF6	61	D61V	gAT	gTC	1	2	B.1.1.311	0.000358
ORF6	61	D61V	gAT	gTC	1	2	B.1.1.519	0.00004
ORF6	61	D61V	gAt	gTt	1	2	B.1.1.519	0.00004
ORF6	61	D61V	gAt	gTt	1	2	B.1.160.11	0.005714
ORF6	61	D61V	gAT	gTC	1	2	B.1.160.11	0.005714
ORF6	61	D61V	gAt	gTt	1	2	B.1.177.21	0.000076
ORF6	61	D61V	gAT	gTC	1	2	B.1.177.21	0.000076
ORF6	61	D61V	gAT	gTC	1	2	B.1.240	0.000216
ORF6	61	D61V	gAt	gTt	1	2	B.1.240	0.000216
ORF6	61	D61V	gAT	gTC	1	2	B.1.243	0.00007
ORF6	61	D61V	gAt	gTt	1	2	B.1.243	0.00007
ORF6	61	D61V	gAT	gTC	1	2	B.1.3	0.002618
ORF6	61	D61V	gAt	gTt	1	2	B.1.3	0.002618
ORF6	61	D61V	gAT	gTC	1	2	B.1.369	0.000285
ORF6	61	D61V	gAt	gTt	1	2	B.1.369	0.000285
ORF6	61	D61V	gAT	gTC	1	2	B.1.438.1	0.000107
ORF6	61	D61V	gAt	gTt	1	2	B.1.438.1	0.000107
ORF6	61	D61V	gAT	gTC	1	2	B.1.466.2	0.000391
ORF6	61	D61V	gAt	gTt	1	2	B.1.466.2	0.000391
ORF6	61	D61V	gAT	gTC	1	2	B.1.526	0.000024
ORF6	61	D61V	gAt	gTt	1	2	B.1.526	0.000024
ORF6	61	D61V	gAt	gTt	1	2	B.1.582	0.000491
ORF6	61	D61V	gAT	gTC	1	2	B.1.582	0.000491
ORF6	61	D61V	gAT	gTC	1	2	B.1.617.1	0.000129
ORF6	61	D61V	gAt	gTt	1	2	B.1.617.1	0.000129
ORF6	61	D61V	gAt	gTt	1	2	B.3	0.000831
ORF6	61	D61V	gAT	gTC	1	2	B.3	0.000831
ORF6	61	D61V	gAt	gTt	1	2	B.4.7	0.010101
ORF6	61	D61V	gAT	gTC	1	2	B.4.7	0.010101
ORF6	61	D61V	gAT	gTC	1	2	B.40	0.000364
ORF6	61	D61V	gAt	gTt	1	2	B.40	0.000364
ORF6	61	D61V	gAT	gTA	1	2	P.1.12	0.000484
ORF6	61	D61V	gAt	gTt	1	2	P.1.12	0.000484
ORF6	61	D61V	gAT	gTC	1	2	P.1.15	0.000232
ORF6	61	D61V	gAt	gTt	1	2	P.1.15	0.000232
ORF6	61	D61V	gAt	gTt	1	2	P.2	0.000187
ORF6	61	D61V	gAT	gTA	1	2	P.2	0.000187
ORF6	61	D61V	gAT	gTC	1	2	Q.1	0.000126
ORF6	61	D61V	gAt	gTt	1	2	Q.1	0.000126
ORF6	61	D61V	gAt	gTt	1	1	AY.103	0.000006
ORF6	61	D61V	gAt	gTt	1	1	AY.29.1	0.000221
ORF6	61	D61V	gAT	gTC	1	1	AY.30	0.000396
ORF6	61	D61V	gAt	gTt	1	1	AY.4.4	0.000409
ORF6	61	D61V	gAt	gTt	1	1	AY.46.3	0.000934
ORF6	61	D61V	gAt	gTt	1	1	AY.84	0.000437
ORF6	61	D61V	gAt	gTt	1	1	AY.9.2	0.000037
ORF6	61	D61V	gAt	gTt	1	1	B.1.1.1	0.000327
ORF6	61	D61V	gAt	gTt	1	1	B.1.1.192	0.002309
ORF6	61	D61V	gAt	gTt	1	1	B.1.1.214	0.000055
ORF6	61	D61V	gAt	gTt	1	1	B.1.1.225	0.007194
ORF6	61	D61V	gAt	gTt	1	1	B.1.1.28	0.000311
ORF6	61	D61V	gAt	gTt	1	1	B.1.160	0.000031
ORF6	61	D61V	gAt	gTt	1	1	B.1.177.15	0.000631
ORF6	61	D61V	gAt	gTt	1	1	B.1.177.4	0.000211
ORF6	61	D61V	gAT	gTC	1	1	B.1.177.54	0.000606
ORF6	61	D61V	gAt	gTt	1	1	B.1.36	0.000146
ORF6	61	D61V	gAt	gTt	1	1	B.1.415	0.014286
ORF6	61	D61V	gAt	gTt	1	1	B.1.426	0.001009
ORF6	61	D61V	gAt	gTt	1	1	B.1.429	0.000024
ORF6	61	D61V	gAt	gTt	1	1	B.1.452	0.013699
ORF6	61	D61V	gAt	gTt	1	1	C.35	0.000774
ORF6	61	D61V	gAt	gTt	1	1	P.1.16	0.000374
ORF6	61	D61V	gAt	gTt	1	1	P.7	0.004367

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.