CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = Y109D

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	109	Y109D		nonsyn	Tat	Gat	10	8	0.8	25717-25719
ORF3a	109	Y109D		nonsyn	TaT	GaC	10	2	0.2	25717-25719

Details of the mutation Y109D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	109	Y109D	Tat	Gat	8	10	All	0.000002
ORF3a	109	Y109D	TaT	GaC	2	10	All	0
ORF3a	109	Y109D	Tat	Gat	5	5	B.1.1.7	0.000004
ORF3a	109	Y109D	TaT	GaC	1	2		0.055556
ORF3a	109	Y109D	Tat	Gat	1	2		0.055556
ORF3a	109	Y109D	TaT	GaC	1	2	B.1.91	0.002075
ORF3a	109	Y109D	Tat	Gat	1	2	B.1.91	0.002075
ORF3a	109	Y109D	Tat	Gat	1	1	B.1.36.36	0.000602

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.