CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = V256S

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	256	V256S		nonsyn	GTt	AGt	143	76	0.531469	26158-26160
ORF3a	256	V256S		nonsyn	GTT	AGC	143	67	0.468531	26158-26160

Details of the mutation V256S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	256	V256S	GTt	AGt	76	143	All	0.000015
ORF3a	256	V256S	GTT	AGC	67	143	All	0.000013
ORF3a	256	V256S	GTt	AGt	47	89	B.1.621	0.00416
ORF3a	256	V256S	GTT	AGC	42	89	B.1.621	0.003718
ORF3a	256	V256S	GTt	AGt	26	49	AY.113	0.003702
ORF3a	256	V256S	GTT	AGC	23	49	AY.113	0.003275
ORF3a	256	V256S	GTt	AGt	1	2	AY.117	0.000085
ORF3a	256	V256S	GTT	AGC	1	2	AY.117	0.000085
ORF3a	256	V256S	GTT	AGC	1	2	AY.26	0.000028
ORF3a	256	V256S	GTt	AGt	1	2	AY.26	0.000028
ORF3a	256	V256S	GTt	AGt	1	1	AY.3	0.00001

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.