CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = L41F

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	41	L41F		nonsyn	Ctc	Ttc	11199	11196	0.999732	25513-25515
ORF3a	41	L41F		nonsyn	CtC	TtT	11199	3	0.000267881	25513-25515

Details of the mutation L41F within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	41	L41F	Ctc	Ttc	11196	11199	All	0.002141
ORF3a	41	L41F	CtC	TtT	3	11199	All	0.000001
ORF3a	41	L41F	Ctc	Ttc	2185	2187	AY.98.1	0.105821
ORF3a	41	L41F	CtC	TtT	2	2187	AY.98.1	0.000097
ORF3a	41	L41F	Ctc	Ttc	1875	1875	AY.4	0.002918
ORF3a	41	L41F	Ctc	Ttc	1430	1430	B.1.1.7	0.00128
ORF3a	41	L41F	Ctc	Ttc	573	574	B.1.617.2	0.002158
ORF3a	41	L41F	CtC	TtT	1	574	B.1.617.2	0.000004
ORF3a	41	L41F	Ctc	Ttc	543	543	AY.43	0.002406
ORF3a	41	L41F	Ctc	Ttc	511	511	B.1.628	0.180056
ORF3a	41	L41F	Ctc	Ttc	395	395	B.1.2	0.003478
ORF3a	41	L41F	Ctc	Ttc	340	340	B.1.177	0.004477
ORF3a	41	L41F	Ctc	Ttc	267	267	AY.102	0.007079
ORF3a	41	L41F	Ctc	Ttc	235	235	AY.44	0.00143
ORF3a	41	L41F	Ctc	Ttc	202	202	P.1	0.003182
ORF3a	41	L41F	Ctc	Ttc	174	174	AY.39	0.0043
ORF3a	41	L41F	Ctc	Ttc	147	147	AY.120	0.005465
ORF3a	41	L41F	Ctc	Ttc	129	129	B.1	0.001182
ORF3a	41	L41F	Ctc	Ttc	126	126	B.1.1	0.002286
ORF3a	41	L41F	Ctc	Ttc	100	100	B.1.177.27	0.943396
ORF3a	41	L41F	Ctc	Ttc	93	93	B.1.1.141	0.187123
ORF3a	41	L41F	Ctc	Ttc	91	91	AY.25	0.000547
ORF3a	41	L41F	Ctc	Ttc	88	88	AY.103	0.000546
ORF3a	41	L41F	Ctc	Ttc	86	86	AY.3	0.000855
ORF3a	41	L41F	Ctc	Ttc	85	85	B.1.258.17	0.008838
ORF3a	41	L41F	Ctc	Ttc	69	69	AY.29	0.001088
ORF3a	41	L41F	Ctc	Ttc	65	65	B.1.1.284	0.006981
ORF3a	41	L41F	Ctc	Ttc	63	63	AY.75	0.003529
ORF3a	41	L41F	Ctc	Ttc	63	63	B.1.177.44	0.032693
ORF3a	41	L41F	Ctc	Ttc	57	57	B.1.563	0.966102
ORF3a	41	L41F	Ctc	Ttc	53	53	A.2.5	0.026447
ORF3a	41	L41F	Ctc	Ttc	42	42	B.1.1.222	0.008568
ORF3a	41	L41F	Ctc	Ttc	40	40	AY.119	0.001412
ORF3a	41	L41F	Ctc	Ttc	34	34	AY.92	0.009767
ORF3a	41	L41F	Ctc	Ttc	34	34	B.1.526	0.000799
ORF3a	41	L41F	Ctc	Ttc	30	30	AY.5	0.000619
ORF3a	41	L41F	Ctc	Ttc	29	29	AY.26	0.000821
ORF3a	41	L41F	Ctc	Ttc	28	28	AY.42	0.001126
ORF3a	41	L41F	Ctc	Ttc	27	27	B.1.621	0.00239
ORF3a	41	L41F	Ctc	Ttc	22	22	AY.68	0.006022
ORF3a	41	L41F	Ctc	Ttc	20	20	B.1.177.81	0.003786
ORF3a	41	L41F	Ctc	Ttc	20	20	B.1.351	0.000595
ORF3a	41	L41F	Ctc	Ttc	20	20	P.1.17	0.003235
ORF3a	41	L41F	Ctc	Ttc	19	19	AY.4.2	0.000412
ORF3a	41	L41F	Ctc	Ttc	19	19	B.1.234	0.002507
ORF3a	41	L41F	Ctc	Ttc	19	19	B.1.565	0.015397
ORF3a	41	L41F	Ctc	Ttc	17	17	B.1.525	0.001924
ORF3a	41	L41F	Ctc	Ttc	16	16	AY.47	0.000498
ORF3a	41	L41F	Ctc	Ttc	15	15	AY.20	0.000583
ORF3a	41	L41F	Ctc	Ttc	14	14	AY.98	0.001106
ORF3a	41	L41F	Ctc	Ttc	14	14	B.1.177.21	0.001071
ORF3a	41	L41F	Ctc	Ttc	13	13	AY.39.1	0.000515
ORF3a	41	L41F	Ctc	Ttc	13	13	B.1.258	0.000865
ORF3a	41	L41F	Ctc	Ttc	13	13	B.1.258.11	0.005153
ORF3a	41	L41F	Ctc	Ttc	13	13	B.1.36	0.001897
ORF3a	41	L41F	Ctc	Ttc	12	12	AY.107	0.005592
ORF3a	41	L41F	Ctc	Ttc	12	12	AY.54	0.001144
ORF3a	41	L41F	Ctc	Ttc	12	12	AY.95	0.009132
ORF3a	41	L41F	Ctc	Ttc	12	12	B.1.596	0.001046
ORF3a	41	L41F	Ctc	Ttc	11	11	AY.45	0.001339
ORF3a	41	L41F	Ctc	Ttc	11	11	B.1.1.207	0.013002
ORF3a	41	L41F	Ctc	Ttc	11	11	B.1.243	0.000765
ORF3a	41	L41F	Ctc	Ttc	11	11	B.1.311	0.00302
ORF3a	41	L41F	Ctc	Ttc	11	11	B.1.582	0.005397
ORF3a	41	L41F	Ctc	Ttc	11	11	Q.2	0.006748
ORF3a	41	L41F	Ctc	Ttc	10	10	B.1.1.519	0.000397
ORF3a	41	L41F	Ctc	Ttc	10	10	B.1.160	0.000312
ORF3a	41	L41F	Ctc	Ttc	9	9	AY.46.2	0.005718
ORF3a	41	L41F	Ctc	Ttc	9	9	C.37	0.001045
ORF3a	41	L41F	Ctc	Ttc	8	8	AY.61	0.000838
ORF3a	41	L41F	Ctc	Ttc	8	8	B.1.1.214	0.000444
ORF3a	41	L41F	Ctc	Ttc	8	8	B.1.429	0.000188
ORF3a	41	L41F	Ctc	Ttc	7	7	AY.113	0.000997
ORF3a	41	L41F	Ctc	Ttc	7	7	AY.33	0.000467
ORF3a	41	L41F	Ctc	Ttc	7	7	AY.5.3	0.002362
ORF3a	41	L41F	Ctc	Ttc	7	7	AY.7	0.001372
ORF3a	41	L41F	Ctc	Ttc	7	7	B.1.177.86	0.001284
ORF3a	41	L41F	Ctc	Ttc	7	7	B.1.36.35	0.018229
ORF3a	41	L41F	Ctc	Ttc	7	7	B.40	0.00255
ORF3a	41	L41F	Ctc	Ttc	7	7	D.2	0.000525
ORF3a	41	L41F	Ctc	Ttc	6	6	AY.23	0.000418
ORF3a	41	L41F	Ctc	Ttc	6	6	AY.9.2	0.00022
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.1.187	0.053097
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.1.311	0.002149
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.195	0.030151
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.36.17	0.002964
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.427	0.000303
ORF3a	41	L41F	Ctc	Ttc	6	6	B.1.438.1	0.000644
ORF3a	41	L41F	Ctc	Ttc	6	6	P.1.7	0.001916
ORF3a	41	L41F	Ctc	Ttc	6	6	P.2	0.00112
ORF3a	41	L41F	Ctc	Ttc	6	6	Q.8	0.000989
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.100	0.00023
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.117	0.000423
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.118	0.000313
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.37	0.00158
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.46	0.00052
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.84	0.002187
ORF3a	41	L41F	Ctc	Ttc	5	5	AY.90	0.003422
ORF3a	41	L41F	Ctc	Ttc	5	5	C.36.2	0.172414
ORF3a	41	L41F	Ctc	Ttc	5	5	P.1.12	0.00242
ORF3a	41	L41F	Ctc	Ttc	5	5	Q.1	0.000632
ORF3a	41	L41F	Ctc	Ttc	4	4	A	0.001548
ORF3a	41	L41F	Ctc	Ttc	4	4	A.27	0.006623
ORF3a	41	L41F	Ctc	Ttc	4	4	AA.1	0.028986
ORF3a	41	L41F	Ctc	Ttc	4	4	AY.111	0.000733
ORF3a	41	L41F	Ctc	Ttc	4	4	AY.121	0.000541
ORF3a	41	L41F	Ctc	Ttc	4	4	AY.4.5	0.00043
ORF3a	41	L41F	Ctc	Ttc	4	4	AY.46.6	0.000289
ORF3a	41	L41F	Ctc	Ttc	4	4	AY.87	0.003331
ORF3a	41	L41F	Ctc	Ttc	4	4	B.1.221	0.000284
ORF3a	41	L41F	Ctc	Ttc	4	4	B.1.221.1	0.011628
ORF3a	41	L41F	Ctc	Ttc	4	4	P.1.15	0.000929
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.101	0.001471
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.110	0.000338
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.116	0.00086
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.27	0.000194
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.4.4	0.001227
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.74	0.000347
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.9.1	0.000251
ORF3a	41	L41F	Ctc	Ttc	3	3	AY.93	0.000819
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.1.28	0.000934
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.1.33	0.001263
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.1.369	0.001339
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.1.432	0.003797
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.160.26	0.007264
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.346	0.003932
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.411	0.011111
ORF3a	41	L41F	Ctc	Ttc	3	3	B.1.556	0.022556
ORF3a	41	L41F	Ctc	Ttc	3	3	P.1.1	0.000953
ORF3a	41	L41F	Ctc	Ttc	3	3	P.1.10	0.000808
ORF3a	41	L41F	Ctc	Ttc	3	3	P.1.4	0.00293
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.108	0.002205
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.13	0.000322
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.14	0.000176
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.19	0.002281
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.34	0.000194
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.36	0.000296
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.38	0.000999
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.4.2.1	0.000298
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.5.4	0.000553
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.58	0.001815
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.60	0.001876
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.69	0.000373
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.75.1	0.000361
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.85	0.000854
ORF3a	41	L41F	Ctc	Ttc	2	2	AY.99.2	0.000184
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.174	0.006757
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.231	0.006192
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.27	0.011299
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.294	0.002532
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.322	0.017544
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.37	0.000386
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.370	0.025316
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.1.55	0.025974
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.104	0.00738
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.177.40	0.010309
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.177.52	0.003515
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.177.60	0.000437
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.177.72	0.00678
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.349	0.00143
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.351.2	0.000605
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.36.29	0.001035
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.36.38	0.003284
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.362	0.003082
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.369	0.00057
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.436	0.002058
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.466.2	0.000782
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.499	0.002101
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.564	0.000852
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.595	0.000522
ORF3a	41	L41F	Ctc	Ttc	2	2	B.1.631	0.006734
ORF3a	41	L41F	Ctc	Ttc	2	2	P.1.14	0.000096
ORF3a	41	L41F	Ctc	Ttc	2	2	R.1	0.00018
ORF3a	41	L41F	Ctc	Ttc	1	1	A.1	0.000282
ORF3a	41	L41F	Ctc	Ttc	1	1	A.19	0.009434
ORF3a	41	L41F	Ctc	Ttc	1	1	A.2.5.1	0.004808
ORF3a	41	L41F	Ctc	Ttc	1	1	AE.6	0.038462
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.104	0.001984
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.105	0.000643
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.109	0.00074
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.11	0.001339
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.12	0.000316
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.120.1	0.000321
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.120.2.1	0.000498
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.16	0.00038
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.3.1	0.000085
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.30	0.000396
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.35	0.000233
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.41	0.000294
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.46.3	0.000934
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.59	0.00053
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.6	0.000041
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.62	0.000436
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.63	0.000387
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.67	0.000464
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.7.1	0.000113
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.70	0.000209
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.71	0.000475
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.76	0.004831
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.86	0.00083
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.88	0.000884
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.9	0.000068
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.99	0.001049
ORF3a	41	L41F	Ctc	Ttc	1	1	AY.99.1	0.001553
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.1	0.000327
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.135	0.004695
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.160	0.02381
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.163	0.007634
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.170	0.001247
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.216	0.00089
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.241	0.00207
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.291	0.000742
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.318	0.000302
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.326	0.001761
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.385	0.004464
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.398	0.003226
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.434	0.000349
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.463	0.0625
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.50	0.000679
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.513	0.012346
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.1.522	0.017241
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.126	0.001276
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.160.14	0.002119
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.160.7	0.002079
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.162	0.005025
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.170	0.00431
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.18	0.00116
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.33	0.001645
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.57	0.000281
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.69	0.001484
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.73	0.000566
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.177.83	0.001481
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.214.2	0.0006
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.232	0.000537
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.326	0.007576
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.355	0.011111
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.361	0.001289
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.422	0.000812
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.428.3	0.012821
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.456	0.003268
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.459	0.004082
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.480	0.002488
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.543	0.01
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.544	0.006024
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.577	0.000687
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.587	0.001898
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.602	0.006536
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.605	0.005952
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.611	0.04
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.620	0.000946
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.627	0.00202
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.637	0.000073
ORF3a	41	L41F	Ctc	Ttc	1	1	B.1.88.1	0.004808
ORF3a	41	L41F	Ctc	Ttc	1	1	B.6.6	0.000889
ORF3a	41	L41F	Ctc	Ttc	1	1	C.36	0.000911
ORF3a	41	L41F	Ctc	Ttc	1	1	N.4	0.004255
ORF3a	41	L41F	Ctc	Ttc	1	1	N.5	0.001767
ORF3a	41	L41F	Ctc	Ttc	1	1	P.1.6	0.001946
ORF3a	41	L41F	Ctc	Ttc	1	1	P.3	0.001595
ORF3a	41	L41F	Ctc	Ttc	1	1	Q.3	0.000145

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.