CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = K67R

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	67	K67R		nonsyn	aAg	aGg	527	525	0.996205	25591-25593
ORF3a	67	K67R		nonsyn	aAG	aGA	527	2	0.00379507	25591-25593

Details of the mutation K67R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	67	K67R	aAg	aGg	525	527	All	0.0001
ORF3a	67	K67R	aAG	aGA	2	527	All	0
ORF3a	67	K67R	aAg	aGg	85	85	B.1.2	0.000748
ORF3a	67	K67R	aAg	aGg	66	66	AY.117	0.005578
ORF3a	67	K67R	aAg	aGg	58	58	AY.44	0.000353
ORF3a	67	K67R	aAg	aGg	39	39	AY.4	0.000061
ORF3a	67	K67R	aAg	aGg	36	36	B.1.1.7	0.000032
ORF3a	67	K67R	aAg	aGg	23	23	B.1.258	0.001531
ORF3a	67	K67R	aAg	aGg	23	23	B.1.526	0.000541
ORF3a	67	K67R	aAg	aGg	21	21	B.1.617.2	0.000079
ORF3a	67	K67R	aAg	aGg	20	20	AY.6	0.000823
ORF3a	67	K67R	aAg	aGg	16	16	AY.103	0.000099
ORF3a	67	K67R	aAg	aGg	10	10	AY.25	0.00006
ORF3a	67	K67R	aAg	aGg	9	9	AY.26	0.000255
ORF3a	67	K67R	aAg	aGg	9	9	AY.29	0.000142
ORF3a	67	K67R	aAg	aGg	9	9	AY.39	0.000222
ORF3a	67	K67R	aAg	aGg	8	8	P.1	0.000126
ORF3a	67	K67R	aAg	aGg	7	7	B.1.1.186	0.024055
ORF3a	67	K67R	aAg	aGg	7	7	B.1.177	0.000092
ORF3a	67	K67R	aAg	aGg	6	6	B.1.351	0.000178
ORF3a	67	K67R	aAg	aGg	5	5	AY.100	0.00023
ORF3a	67	K67R	aAg	aGg	5	5	B.1	0.000046
ORF3a	67	K67R	aAg	aGg	5	5	B.1.1.343	0.104167
ORF3a	67	K67R	aAG	aGA	2	4		0.111111
ORF3a	67	K67R	aAg	aGg	2	4		0.111111
ORF3a	67	K67R	aAg	aGg	4	4	AY.36	0.000593
ORF3a	67	K67R	aAg	aGg	4	4	B.1.588	0.00364
ORF3a	67	K67R	aAg	aGg	3	3	AY.4.2	0.000065
ORF3a	67	K67R	aAg	aGg	3	3	AY.4.5	0.000322
ORF3a	67	K67R	aAg	aGg	3	3	B.1.1	0.000054
ORF3a	67	K67R	aAg	aGg	3	3	B.1.221	0.000213
ORF3a	67	K67R	aAg	aGg	3	3	D.2	0.000225
ORF3a	67	K67R	aAg	aGg	3	3	Q.4	0.001364
ORF3a	67	K67R	aAg	aGg	2	2	AY.4.2.1	0.000298
ORF3a	67	K67R	aAg	aGg	2	2	B.1.36.29	0.001035
ORF3a	67	K67R	aAg	aGg	2	2	B.1.427	0.000101
ORF3a	67	K67R	aAg	aGg	2	2	B.1.617.1	0.000258
ORF3a	67	K67R	aAg	aGg	1	1	AY.1	0.000396
ORF3a	67	K67R	aAg	aGg	1	1	AY.116	0.000287
ORF3a	67	K67R	aAg	aGg	1	1	AY.20	0.000039
ORF3a	67	K67R	aAg	aGg	1	1	AY.33	0.000067
ORF3a	67	K67R	aAg	aGg	1	1	AY.34	0.000097
ORF3a	67	K67R	aAg	aGg	1	1	AY.46.2	0.000635
ORF3a	67	K67R	aAg	aGg	1	1	AY.75	0.000056
ORF3a	67	K67R	aAg	aGg	1	1	AY.75.1	0.00018
ORF3a	67	K67R	aAg	aGg	1	1	AY.79	0.001211
ORF3a	67	K67R	aAg	aGg	1	1	AY.9	0.000068
ORF3a	67	K67R	aAg	aGg	1	1	B.1.1.222	0.000204
ORF3a	67	K67R	aAg	aGg	1	1	B.1.177.11	0.001698
ORF3a	67	K67R	aAg	aGg	1	1	B.1.243	0.00007
ORF3a	67	K67R	aAg	aGg	1	1	B.1.245	0.03125
ORF3a	67	K67R	aAg	aGg	1	1	B.1.411	0.003704
ORF3a	67	K67R	aAg	aGg	1	1	B.1.429	0.000024
ORF3a	67	K67R	aAg	aGg	1	1	B.1.466.2	0.000391
ORF3a	67	K67R	aAg	aGg	1	1	B.1.595	0.000261
ORF3a	67	K67R	aAg	aGg	1	1	B.1.596	0.000087
ORF3a	67	K67R	aAg	aGg	1	1	B.1.609	0.000479
ORF3a	67	K67R	aAg	aGg	1	1	B.1.628	0.000352
ORF3a	67	K67R	aAg	aGg	1	1	C.2.1	0.006667

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.