CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = G196X

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	196	G196X		nonsyn	Gga	Tga	43	36	0.837209	25978-25980
ORF3a	196	G196X		nonsyn	GGa	TAa	43	7	0.162791	25978-25980

Details of the mutation G196X within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	196	G196X	Gga	Tga	36	43	All	0.000007
ORF3a	196	G196X	GGa	TAa	7	43	All	0.000001
ORF3a	196	G196X	Gga	Tga	21	28	B.1.1.7	0.000019
ORF3a	196	G196X	GGa	TAa	7	28	B.1.1.7	0.000006
ORF3a	196	G196X	Gga	Tga	6	6	B.1	0.000055
ORF3a	196	G196X	Gga	Tga	1	1	AY.103	0.000006
ORF3a	196	G196X	Gga	Tga	1	1	AY.4	0.000002
ORF3a	196	G196X	Gga	Tga	1	1	AY.44	0.000006
ORF3a	196	G196X	Gga	Tga	1	1	B.1.1.464	0.001473
ORF3a	196	G196X	Gga	Tga	1	1	B.1.1.70	0.000341
ORF3a	196	G196X	Gga	Tga	1	1	B.1.2	0.000009
ORF3a	196	G196X	Gga	Tga	1	1	B.1.221.3	0.000833
ORF3a	196	G196X	Gga	Tga	1	1	B.1.470	0.001404
ORF3a	196	G196X	Gga	Tga	1	1	P.1	0.000016

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.