CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = G196R

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	196	G196R		nonsyn	Gga	Aga	338	336	0.994083	25978-25980
ORF3a	196	G196R		nonsyn	Gga	Cga	338	2	0.00591716	25978-25980

Details of the mutation G196R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	196	G196R	Gga	Aga	336	338	All	0.000064
ORF3a	196	G196R	Gga	Cga	2	338	All	0
ORF3a	196	G196R	Gga	Aga	56	56	B.1.1.7	0.00005
ORF3a	196	G196R	Gga	Aga	39	39	B.1.509	0.033766
ORF3a	196	G196R	Gga	Aga	35	35	AY.25	0.000211
ORF3a	196	G196R	Gga	Aga	35	35	AY.4.2	0.000759
ORF3a	196	G196R	Gga	Aga	34	34	AY.4	0.000053
ORF3a	196	G196R	Gga	Aga	24	25	AY.3	0.000239
ORF3a	196	G196R	Gga	Cga	1	25	AY.3	0.00001
ORF3a	196	G196R	Gga	Aga	17	17	P.1	0.000268
ORF3a	196	G196R	Gga	Aga	12	12	AY.44	0.000073
ORF3a	196	G196R	Gga	Aga	8	8	AY.39	0.000198
ORF3a	196	G196R	Gga	Aga	8	8	AY.43	0.000035
ORF3a	196	G196R	Gga	Aga	8	8	B.1.2	0.00007
ORF3a	196	G196R	Gga	Aga	7	7	B.1.177.21	0.000535
ORF3a	196	G196R	Gga	Aga	7	7	B.1.429	0.000165
ORF3a	196	G196R	Gga	Aga	4	4	AY.103	0.000025
ORF3a	196	G196R	Gga	Aga	4	4	B.1.617.2	0.000015
ORF3a	196	G196R	Gga	Aga	3	3	AY.62	0.001307
ORF3a	196	G196R	Gga	Aga	3	3	B.1	0.000027
ORF3a	196	G196R	Gga	Aga	3	3	B.1.160	0.000094
ORF3a	196	G196R	Gga	Aga	2	2	AY.24	0.000862
ORF3a	196	G196R	Gga	Aga	2	2	AY.29	0.000032
ORF3a	196	G196R	Gga	Aga	2	2	AY.34	0.000194
ORF3a	196	G196R	Gga	Aga	2	2	AY.42	0.00008
ORF3a	196	G196R	Gga	Aga	2	2	B.1.1.306	0.000877
ORF3a	196	G196R	Gga	Aga	1	1	A	0.000387
ORF3a	196	G196R	Gga	Aga	1	1	AY.116	0.000287
ORF3a	196	G196R	Gga	Aga	1	1	AY.13	0.000161
ORF3a	196	G196R	Gga	Aga	1	1	AY.4.4	0.000409
ORF3a	196	G196R	Gga	Aga	1	1	AY.53	0.000288
ORF3a	196	G196R	Gga	Aga	1	1	AY.61	0.000105
ORF3a	196	G196R	Gga	Aga	1	1	AY.98	0.000079
ORF3a	196	G196R	Gga	Aga	1	1	B.1.1.141	0.002012
ORF3a	196	G196R	Gga	Aga	1	1	B.1.1.277	0.000759
ORF3a	196	G196R	Gga	Aga	1	1	B.1.1.87	0.066667
ORF3a	196	G196R	Gga	Aga	1	1	B.1.177	0.000013
ORF3a	196	G196R	Gga	Aga	1	1	B.1.177.25	0.014925
ORF3a	196	G196R	Gga	Aga	1	1	B.1.221	0.000071
ORF3a	196	G196R	Gga	Aga	1	1	B.1.222	0.001692
ORF3a	196	G196R	Gga	Cga	1	1	B.1.36	0.000146
ORF3a	196	G196R	Gga	Aga	1	1	B.1.391	0.001127
ORF3a	196	G196R	Gga	Aga	1	1	B.1.399	0.001934
ORF3a	196	G196R	Gga	Aga	1	1	B.1.427	0.00005
ORF3a	196	G196R	Gga	Aga	1	1	B.1.526	0.000024
ORF3a	196	G196R	Gga	Aga	1	1	P.1.7	0.000319

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.