CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : Mut = D27D

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	27	D27D		syn	gaT	gaC	2947	2947	1	25471-25473

Details of the mutation D27D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	27	D27D	gaT	gaC	2947	2947	All	0.000564
ORF3a	27	D27D	gaT	gaC	842	842	B.1.429	0.019811
ORF3a	27	D27D	gaT	gaC	483	483	B.1.1.241	1
ORF3a	27	D27D	gaT	gaC	393	393	AY.4	0.000612
ORF3a	27	D27D	gaT	gaC	263	263	AH.3	1
ORF3a	27	D27D	gaT	gaC	146	146	B.1.1.7	0.000131
ORF3a	27	D27D	gaT	gaC	113	113	B.1.617.2	0.000425
ORF3a	27	D27D	gaT	gaC	83	83	AH.2	1
ORF3a	27	D27D	gaT	gaC	78	78	AY.114	0.018026
ORF3a	27	D27D	gaT	gaC	71	71	B.1	0.00065
ORF3a	27	D27D	gaT	gaC	63	63	B.1.351.2	0.019062
ORF3a	27	D27D	gaT	gaC	58	58	B.1.1	0.001052
ORF3a	27	D27D	gaT	gaC	53	53	AY.43	0.000235
ORF3a	27	D27D	gaT	gaC	45	45	AY.46.6	0.003249
ORF3a	27	D27D	gaT	gaC	34	34	B.1.243	0.002366
ORF3a	27	D27D	gaT	gaC	22	22	AY.44	0.000134
ORF3a	27	D27D	gaT	gaC	20	20	AY.29	0.000315
ORF3a	27	D27D	gaT	gaC	12	12	AY.39.1	0.000475
ORF3a	27	D27D	gaT	gaC	12	12	B.1.2	0.000106
ORF3a	27	D27D	gaT	gaC	9	9	B.1.596	0.000784
ORF3a	27	D27D	gaT	gaC	8	8	B.1.177	0.000105
ORF3a	27	D27D	gaT	gaC	8	8	B.1.526	0.000188
ORF3a	27	D27D	gaT	gaC	7	7	AH.1	1
ORF3a	27	D27D	gaT	gaC	7	7	AY.75.1	0.001262
ORF3a	27	D27D	gaT	gaC	6	6	AY.25	0.000036
ORF3a	27	D27D	gaT	gaC	6	6	AY.3	0.00006
ORF3a	27	D27D	gaT	gaC	5	5	AY.103	0.000031
ORF3a	27	D27D	gaT	gaC	5	5	AY.61	0.000524
ORF3a	27	D27D	gaT	gaC	5	5	B.1.1.232	0.009074
ORF3a	27	D27D	gaT	gaC	5	5	B.1.1.28	0.001556
ORF3a	27	D27D	gaT	gaC	5	5	B.1.234	0.00066
ORF3a	27	D27D	gaT	gaC	3	3	AY.39	0.000074
ORF3a	27	D27D	gaT	gaC	3	3	AY.63	0.001161
ORF3a	27	D27D	gaT	gaC	3	3	B.1.221	0.000213
ORF3a	27	D27D	gaT	gaC	3	3	B.1.239	0.003663
ORF3a	27	D27D	gaT	gaC	3	3	P.1.1	0.000953
ORF3a	27	D27D	gaT	gaC	3	3	W.1	0.026087
ORF3a	27	D27D	gaT	gaC	2	2	AY.108	0.002205
ORF3a	27	D27D	gaT	gaC	2	2	AY.120	0.000074
ORF3a	27	D27D	gaT	gaC	2	2	AY.120.1	0.000642
ORF3a	27	D27D	gaT	gaC	2	2	AY.27	0.000129
ORF3a	27	D27D	gaT	gaC	2	2	AY.4.2	0.000043
ORF3a	27	D27D	gaT	gaC	2	2	AY.47	0.000062
ORF3a	27	D27D	gaT	gaC	2	2	AY.6	0.000082
ORF3a	27	D27D	gaT	gaC	2	2	AY.98	0.000158
ORF3a	27	D27D	gaT	gaC	2	2	B.1.1.216	0.001781
ORF3a	27	D27D	gaT	gaC	2	2	B.1.1.294	0.002532
ORF3a	27	D27D	gaT	gaC	2	2	B.1.36	0.000292
ORF3a	27	D27D	gaT	gaC	2	2	B.1.618	0.008065
ORF3a	27	D27D	gaT	gaC	2	2	B.3	0.001661
ORF3a	27	D27D	gaT	gaC	2	2	P.1.17	0.000324
ORF3a	27	D27D	gaT	gaC	1	1	AY.100	0.000046
ORF3a	27	D27D	gaT	gaC	1	1	AY.102	0.000027
ORF3a	27	D27D	gaT	gaC	1	1	AY.105	0.000643
ORF3a	27	D27D	gaT	gaC	1	1	AY.106	0.000335
ORF3a	27	D27D	gaT	gaC	1	1	AY.109	0.00074
ORF3a	27	D27D	gaT	gaC	1	1	AY.121	0.000135
ORF3a	27	D27D	gaT	gaC	1	1	AY.20	0.000039
ORF3a	27	D27D	gaT	gaC	1	1	AY.33	0.000067
ORF3a	27	D27D	gaT	gaC	1	1	AY.46	0.000104
ORF3a	27	D27D	gaT	gaC	1	1	AY.9	0.000068
ORF3a	27	D27D	gaT	gaC	1	1	AY.9.2	0.000037
ORF3a	27	D27D	gaT	gaC	1	1	AY.99	0.001049
ORF3a	27	D27D	gaT	gaC	1	1	B.1.1.253	0.002506
ORF3a	27	D27D	gaT	gaC	1	1	B.1.1.311	0.000358
ORF3a	27	D27D	gaT	gaC	1	1	B.1.1.317	0.000412
ORF3a	27	D27D	gaT	gaC	1	1	B.1.1.519	0.00004
ORF3a	27	D27D	gaT	gaC	1	1	B.1.1.70	0.000341
ORF3a	27	D27D	gaT	gaC	1	1	B.1.111	0.001175
ORF3a	27	D27D	gaT	gaC	1	1	B.1.177.73	0.000566
ORF3a	27	D27D	gaT	gaC	1	1	B.1.180	0.05
ORF3a	27	D27D	gaT	gaC	1	1	B.1.258	0.000067
ORF3a	27	D27D	gaT	gaC	1	1	B.1.311	0.000275
ORF3a	27	D27D	gaT	gaC	1	1	B.1.351	0.00003
ORF3a	27	D27D	gaT	gaC	1	1	B.1.36.22	0.001208
ORF3a	27	D27D	gaT	gaC	1	1	B.1.515	0.014493
ORF3a	27	D27D	gaT	gaC	1	1	B.1.525	0.000113
ORF3a	27	D27D	gaT	gaC	1	1	B.1.561	0.000397
ORF3a	27	D27D	gaT	gaC	1	1	B.1.595	0.000261
ORF3a	27	D27D	gaT	gaC	1	1	B.1.621.1	0.000506
ORF3a	27	D27D	gaT	gaC	1	1	B.1.93	0.000934
ORF3a	27	D27D	gaT	gaC	1	1	B.6.6	0.000889
ORF3a	27	D27D	gaT	gaC	1	1	P.1	0.000016
ORF3a	27	D27D	gaT	gaC	1	1	P.1.14	0.000048
ORF3a	27	D27D	gaT	gaC	1	1	P.1.15	0.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.