CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : CodonNum = 34 & Codon = Ccg

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	34	T34P		nonsyn	Acg	Ccg	30	30	1	25492-25494

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	34	T34P	Acg	Ccg	30	30	All	0.000006
ORF3a	34	T34P	Acg	Ccg	7	7	AY.25	0.000042
ORF3a	34	T34P	Acg	Ccg	4	4	B.1.617.2	0.000015
ORF3a	34	T34P	Acg	Ccg	3	3	A	0.001161
ORF3a	34	T34P	Acg	Ccg	2	2	AY.4	0.000003
ORF3a	34	T34P	Acg	Ccg	2	2	B.1.1	0.000036
ORF3a	34	T34P	Acg	Ccg	2	2	B.1.1.7	0.000002
ORF3a	34	T34P	Acg	Ccg	1	1	AW.1	0.003049
ORF3a	34	T34P	Acg	Ccg	1	1	AY.102	0.000027
ORF3a	34	T34P	Acg	Ccg	1	1	AY.27	0.000065
ORF3a	34	T34P	Acg	Ccg	1	1	AY.46.2	0.000635
ORF3a	34	T34P	Acg	Ccg	1	1	AY.88	0.000884
ORF3a	34	T34P	Acg	Ccg	1	1	B.1	0.000009
ORF3a	34	T34P	Acg	Ccg	1	1	B.1.1.216	0.00089
ORF3a	34	T34P	Acg	Ccg	1	1	B.1.1.33	0.000421
ORF3a	34	T34P	Acg	Ccg	1	1	B.1.177.11	0.001698
ORF3a	34	T34P	Acg	Ccg	1	1	B.1.351	0.00003

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.