CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF3a : CodonNum = 27 & Codon = gaA

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF3a	27	D27E		nonsyn	gaT	gaA	55	21	0.381818	25471-25473

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF3a	27	D27E	gaT	gaA	21	55	All	0.000004
ORF3a	27	D27E	gaT	gaA	6	6	A.2.5	0.002994
ORF3a	27	D27E	gaT	gaA	3	5		0.166667
ORF3a	27	D27E	gaT	gaA	2	3	B.1.617.2	0.000008
ORF3a	27	D27E	gaT	gaA	2	2	AY.3.1	0.000171
ORF3a	27	D27E	gaT	gaA	1	2	AY.4	0.000002
ORF3a	27	D27E	gaT	gaA	2	2	B.1.1.25	0.001137
ORF3a	27	D27E	gaT	gaA	1	2	B.1.1.7	0.000001
ORF3a	27	D27E	gaT	gaA	1	1	AY.43	0.000004
ORF3a	27	D27E	gaT	gaA	1	1	AY.47	0.000031
ORF3a	27	D27E	gaT	gaA	1	1	B.1.497	0.000315
ORF3a	27	D27E	gaT	gaA	1	1	P.1	0.000016

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.