CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp8 : CodonNum = 138

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp8138Y138HY4080HnonsynTatCat10111011112503-12505
ORF1ab/nsp8138Y138YY4080YsyntaTtaC901901112503-12505
ORF1ab/nsp8138Y138CY4080CnonsyntAttGt126126112503-12505
ORF1ab/nsp8138Y138delY4080deldelTAT---4040112503-12505
ORF1ab/nsp8138Y138del1Y4080del1delTat-at1290.7512503-12505
ORF1ab/nsp8138Y138del1Y4080del1deltaTta-1220.16666712503-12505
ORF1ab/nsp8138Y138del1Y4080del1deltAtt-t1210.083333312503-12505
ORF1ab/nsp8138Y138XY4080XnonsyntaTtaA740.57142912503-12505
ORF1ab/nsp8138Y138XY4080XnonsyntaTtaG730.42857112503-12505
ORF1ab/nsp8138Y138VY4080VnonsynTAtGTt530.612503-12505
ORF1ab/nsp8138Y138VY4080VnonsynTATGTC520.412503-12505
ORF1ab/nsp8138Y138FY4080FnonsyntAttTt33112503-12505
ORF1ab/nsp8138Y138del2Y4080del2delTAt--t22112503-12505
ORF1ab/nsp8138Y138GY4080GnonsynTAtGGt22112503-12505
ORF1ab/nsp8138Y138SY4080SnonsyntAttCt11112503-12505
ORF1ab/nsp8138Y138NY4080NnonsynTatAat11112503-12505

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp8138Y138HTatCat10111011All0.000193
ORF1ab/nsp8138Y138YtaTtaC901901All0.000172
ORF1ab/nsp8138Y138HTatCat489489B.1.1.4480.993902
ORF1ab/nsp8138Y138YtaTtaC299299AY.250.001798
ORF1ab/nsp8138Y138HTatCat296296B.1.1.540.89426
ORF1ab/nsp8138Y138YtaTtaC139139AY.440.000846
ORF1ab/nsp8138Y138CtAttGt126126All0.000024
ORF1ab/nsp8138Y138YtaTtaC9595B.1.617.20.000358
ORF1ab/nsp8138Y138YtaTtaC8383AY.1030.000515
ORF1ab/nsp8138Y138YtaTtaC5757AY.230.003976
ORF1ab/nsp8138Y138YtaTtaC4848B.1.1.70.000043
ORF1ab/nsp8138Y138HTatCat4747AY.1030.000292
ORF1ab/nsp8138Y138delTAT---4040All0.000008
ORF1ab/nsp8138Y138YtaTtaC4040AY.1180.002506
ORF1ab/nsp8138Y138YtaTtaC3939AY.9.20.001432
ORF1ab/nsp8138Y138CtAttGt3333AY.420.001328
ORF1ab/nsp8138Y138HTatCat3333B.10.000302
ORF1ab/nsp8138Y138YtaTtaC2727AY.750.001513
ORF1ab/nsp8138Y138HTatCat2727B.1.10.00049
ORF1ab/nsp8138Y138CtAttGt2727B.1.258.140.026471
ORF1ab/nsp8138Y138YtaTtaC1515AY.46.60.001083
ORF1ab/nsp8138Y138delTAT---1515B.1.1.70.000013
ORF1ab/nsp8138Y138CtAttGt1414AY.40.000022
ORF1ab/nsp8138Y138HTatCat1414B.1.1.70.000013
ORF1ab/nsp8138Y138del1Tat-at912All0.000002
ORF1ab/nsp8138Y138del1taTta-212All0
ORF1ab/nsp8138Y138del1tAtt-t112All0
ORF1ab/nsp8138Y138HTatCat1212AY.430.000053
ORF1ab/nsp8138Y138YtaTtaC99AY.40.000014
ORF1ab/nsp8138Y138HTatCat88AY.40.000012
ORF1ab/nsp8138Y138XtaTtaA47All0.000001
ORF1ab/nsp8138Y138XtaTtaG37All0.000001
ORF1ab/nsp8138Y138CtAttGt77AY.1170.000592
ORF1ab/nsp8138Y138CtAttGt66B.1.1.5190.000238
ORF1ab/nsp8138Y138HTatCat66B.1.20.000053
ORF1ab/nsp8138Y138HTatCat66B.1.4430.028037
ORF1ab/nsp8138Y138HTatCat66B.1.617.20.000023
ORF1ab/nsp8138Y138HTatCat66P.1.130.005391
ORF1ab/nsp8138Y138VTAtGTt35All0.000001
ORF1ab/nsp8138Y138VTATGTC25All0
ORF1ab/nsp8138Y138YtaTtaC55B.1.6210.000443
ORF1ab/nsp8138Y138HTatCat44AY.250.000024
ORF1ab/nsp8138Y138CtAttGt44AY.250.000024
ORF1ab/nsp8138Y138HTatCat44AY.340.000388
ORF1ab/nsp8138Y138YtaTtaC44AY.430.000018
ORF1ab/nsp8138Y138delTAT---44AY.430.000018
ORF1ab/nsp8138Y138CtAttGt44B.1.1.70.000004
ORF1ab/nsp8138Y138HTatCat44B.1.1770.000053
ORF1ab/nsp8138Y138CtAttGt44P.1.100.001078
ORF1ab/nsp8138Y138FtAttTt33All0.000001
ORF1ab/nsp8138Y138CtAttGt33AY.260.000085
ORF1ab/nsp8138Y138HTatCat33AY.39.10.000119
ORF1ab/nsp8138Y138HTatCat33AY.440.000018
ORF1ab/nsp8138Y138YtaTtaC33AY.460.000312
ORF1ab/nsp8138Y138del1Tat-at33B.10.000027
ORF1ab/nsp8138Y138HTatCat33B.1.1.1660.1
ORF1ab/nsp8138Y138YtaTtaC33B.1.20.000026
ORF1ab/nsp8138Y138CtAttGt33B.1.617.20.000011
ORF1ab/nsp8138Y138HTatCat33P.10.000047
ORF1ab/nsp8138Y138YtaTtaC33P.10.000047
ORF1ab/nsp8138Y138XtaTtaG220.111111
ORF1ab/nsp8138Y138del2TAt--t220.111111
ORF1ab/nsp8138Y138VTATGTC220.111111
ORF1ab/nsp8138Y138CtAttGt220.111111
ORF1ab/nsp8138Y138GTAtGGt22All0
ORF1ab/nsp8138Y138del2TAt--t22All0
ORF1ab/nsp8138Y138CtAttGt22AY.1000.000092
ORF1ab/nsp8138Y138YtaTtaC22AY.1020.000053
ORF1ab/nsp8138Y138HTatCat22AY.1020.000053
ORF1ab/nsp8138Y138YtaTtaC22AY.390.000049
ORF1ab/nsp8138Y138HTatCat22AY.390.000049
ORF1ab/nsp8138Y138delTAT---22AY.750.000112
ORF1ab/nsp8138Y138YtaTtaC22B.1.10.000036
ORF1ab/nsp8138Y138YtaTtaC22B.1.1.3690.000892
ORF1ab/nsp8138Y138GTAtGGt22B.1.1.70.000002
ORF1ab/nsp8138Y138XtaTtaA22B.1.1.70.000002
ORF1ab/nsp8138Y138HTatCat22B.1.1600.000062
ORF1ab/nsp8138Y138YtaTtaC22B.1.177.280.014815
ORF1ab/nsp8138Y138del1tAtt-t12B.1.20.000009
ORF1ab/nsp8138Y138del1Tat-at12B.1.20.000009
ORF1ab/nsp8138Y138YtaTtaC22B.1.2210.000142
ORF1ab/nsp8138Y138HTatCat22B.1.2400.000431
ORF1ab/nsp8138Y138HTatCat22B.1.3510.000059
ORF1ab/nsp8138Y138CtAttGt22B.1.5950.000522
ORF1ab/nsp8138Y138HTatCat22B.1.5960.000174
ORF1ab/nsp8138Y138CtAttGt22C.370.000232
ORF1ab/nsp8138Y138delTAT---11A0.000387
ORF1ab/nsp8138Y138delTAT---11AD.20.000219
ORF1ab/nsp8138Y138CtAttGt11AE.30.032258
ORF1ab/nsp8138Y138NTatAat11All0
ORF1ab/nsp8138Y138StAttCt11All0
ORF1ab/nsp8138Y138YtaTtaC11AY.1110.000183
ORF1ab/nsp8138Y138YtaTtaC11AY.1160.000287
ORF1ab/nsp8138Y138YtaTtaC11AY.1170.000085
ORF1ab/nsp8138Y138CtAttGt11AY.1200.000037
ORF1ab/nsp8138Y138HTatCat11AY.1200.000037
ORF1ab/nsp8138Y138YtaTtaC11AY.140.000088
ORF1ab/nsp8138Y138HTatCat11AY.200.000039
ORF1ab/nsp8138Y138delTAT---11AY.250.000006
ORF1ab/nsp8138Y138del1Tat-at11AY.250.000006
ORF1ab/nsp8138Y138HTatCat11AY.260.000028
ORF1ab/nsp8138Y138CtAttGt11AY.290.000016
ORF1ab/nsp8138Y138YtaTtaC11AY.30.00001
ORF1ab/nsp8138Y138YtaTtaC11AY.300.000396
ORF1ab/nsp8138Y138YtaTtaC11AY.350.000233
ORF1ab/nsp8138Y138YtaTtaC11AY.380.000499
ORF1ab/nsp8138Y138delTAT---11AY.40.000002
ORF1ab/nsp8138Y138delTAT---11AY.4.50.000107
ORF1ab/nsp8138Y138YtaTtaC11AY.420.00004
ORF1ab/nsp8138Y138CtAttGt11AY.430.000004
ORF1ab/nsp8138Y138CtAttGt11AY.450.000122
ORF1ab/nsp8138Y138delTAT---11AY.460.000104
ORF1ab/nsp8138Y138delTAT---11AY.46.20.000635
ORF1ab/nsp8138Y138HTatCat11AY.470.000031
ORF1ab/nsp8138Y138CtAttGt11AY.470.000031
ORF1ab/nsp8138Y138YtaTtaC11AY.50.000021
ORF1ab/nsp8138Y138YtaTtaC11AY.600.000938
ORF1ab/nsp8138Y138HTatCat11AY.680.000274
ORF1ab/nsp8138Y138HTatCat11AY.7.10.000113
ORF1ab/nsp8138Y138HTatCat11AY.750.000056
ORF1ab/nsp8138Y138delTAT---11AY.80.000606
ORF1ab/nsp8138Y138HTatCat11AY.830.001724
ORF1ab/nsp8138Y138CtAttGt11AY.9.10.000084
ORF1ab/nsp8138Y138HTatCat11B0.000128
ORF1ab/nsp8138Y138FtAttTt11B0.000128
ORF1ab/nsp8138Y138NTatAat11B.10.000009
ORF1ab/nsp8138Y138XtaTtaA11B.10.000009
ORF1ab/nsp8138Y138delTAT---11B.10.000009
ORF1ab/nsp8138Y138YtaTtaC11B.10.000009
ORF1ab/nsp8138Y138FtAttTt11B.1.10.000018
ORF1ab/nsp8138Y138CtAttGt11B.1.10.000018
ORF1ab/nsp8138Y138delTAT---11B.1.10.000018
ORF1ab/nsp8138Y138XtaTtaA11B.1.10.000018
ORF1ab/nsp8138Y138del1taTta-11B.1.1.10.000327
ORF1ab/nsp8138Y138YtaTtaC11B.1.1.2220.000204
ORF1ab/nsp8138Y138HTatCat11B.1.1.2730.006757
ORF1ab/nsp8138Y138delTAT---11B.1.1.280.000311
ORF1ab/nsp8138Y138HTatCat11B.1.1.390.00051
ORF1ab/nsp8138Y138YtaTtaC11B.1.1.3980.003226
ORF1ab/nsp8138Y138HTatCat11B.1.1.4090.002833
ORF1ab/nsp8138Y138del1Tat-at11B.1.1.4480.002033
ORF1ab/nsp8138Y138delTAT---11B.1.1.4480.002033
ORF1ab/nsp8138Y138CtAttGt11B.1.1.4640.001473
ORF1ab/nsp8138Y138YtaTtaC11B.1.1.5190.00004
ORF1ab/nsp8138Y138HTatCat11B.1.1.5230.001563
ORF1ab/nsp8138Y138VTAtGTt11B.1.1.70.000001
ORF1ab/nsp8138Y138YtaTtaC11B.1.1.700.000341
ORF1ab/nsp8138Y138StAttCt11B.1.1.700.000341
ORF1ab/nsp8138Y138del1Tat-at11B.1.1600.000031
ORF1ab/nsp8138Y138YtaTtaC11B.1.160.220.006757
ORF1ab/nsp8138Y138delTAT---11B.1.1770.000013
ORF1ab/nsp8138Y138HTatCat11B.1.177.210.000076
ORF1ab/nsp8138Y138HTatCat11B.1.177.730.000566
ORF1ab/nsp8138Y138HTatCat11B.1.177.860.000183
ORF1ab/nsp8138Y138delTAT---11B.1.177.90.001332
ORF1ab/nsp8138Y138VTAtGTt11B.1.20.000009
ORF1ab/nsp8138Y138delTAT---11B.1.20.000009
ORF1ab/nsp8138Y138HTatCat11B.1.2060.000816
ORF1ab/nsp8138Y138del1taTta-11B.1.2210.000071
ORF1ab/nsp8138Y138CtAttGt11B.1.360.000146
ORF1ab/nsp8138Y138HTatCat11B.1.3620.001541
ORF1ab/nsp8138Y138XtaTtaG11B.1.4620.007246
ORF1ab/nsp8138Y138YtaTtaC11B.1.4700.001404
ORF1ab/nsp8138Y138VTAtGTt11B.1.5090.000866
ORF1ab/nsp8138Y138HTatCat11B.1.5250.000113
ORF1ab/nsp8138Y138HTatCat11B.1.5260.000024
ORF1ab/nsp8138Y138del1Tat-at11B.1.5260.000024
ORF1ab/nsp8138Y138del1Tat-at11B.1.5960.000087
ORF1ab/nsp8138Y138HTatCat11B.1.617.10.000129
ORF1ab/nsp8138Y138delTAT---11B.1.617.20.000004
ORF1ab/nsp8138Y138CtAttGt11B.1.6210.000089
ORF1ab/nsp8138Y138CtAttGt11B.1.6370.000073
ORF1ab/nsp8138Y138HTatCat11B.1.760.011364
ORF1ab/nsp8138Y138HTatCat11B.6.60.000889
ORF1ab/nsp8138Y138HTatCat11C.350.000774
ORF1ab/nsp8138Y138delTAT---11C.360.000911
ORF1ab/nsp8138Y138HTatCat11D.20.000075
ORF1ab/nsp8138Y138delTAT---11N.40.004255
ORF1ab/nsp8138Y138FtAttTt11P.10.000016
ORF1ab/nsp8138Y138CtAttGt11P.1.120.000484
ORF1ab/nsp8138Y138YtaTtaC11P.1.120.000484
ORF1ab/nsp8138Y138YtaTtaC11P.1.140.000048
ORF1ab/nsp8138Y138delTAT---11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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