CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp7 : Mut = E50G

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp7	50	E50G	E3909G	nonsyn	gAa	gGa	2562	2562	1	11990-11992

Details of the mutation E50G within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp7	50	E50G	gAa	gGa	2562	2562	All	0.00049
ORF1ab/nsp7	50	E50G	gAa	gGa	670	670	B.1.1.433	0.954416
ORF1ab/nsp7	50	E50G	gAa	gGa	323	323	AY.4	0.000503
ORF1ab/nsp7	50	E50G	gAa	gGa	176	176	AY.25	0.001059
ORF1ab/nsp7	50	E50G	gAa	gGa	100	100	AY.3	0.000995
ORF1ab/nsp7	50	E50G	gAa	gGa	100	100	B.1.1.7	0.00009
ORF1ab/nsp7	50	E50G	gAa	gGa	95	95	AY.43	0.000421
ORF1ab/nsp7	50	E50G	gAa	gGa	84	84	B.1.2	0.00074
ORF1ab/nsp7	50	E50G	gAa	gGa	80	80	B.1.617.2	0.000301
ORF1ab/nsp7	50	E50G	gAa	gGa	79	79	AY.36	0.011709
ORF1ab/nsp7	50	E50G	gAa	gGa	62	62	B.1.177.57	0.017421
ORF1ab/nsp7	50	E50G	gAa	gGa	53	53	AY.44	0.000323
ORF1ab/nsp7	50	E50G	gAa	gGa	49	49	B.1.177	0.000645
ORF1ab/nsp7	50	E50G	gAa	gGa	40	40	AY.103	0.000248
ORF1ab/nsp7	50	E50G	gAa	gGa	37	37	AY.3.1	0.003155
ORF1ab/nsp7	50	E50G	gAa	gGa	33	33	B.1	0.000302
ORF1ab/nsp7	50	E50G	gAa	gGa	31	31	B.1.177.21	0.002371
ORF1ab/nsp7	50	E50G	gAa	gGa	30	30	AY.33	0.002003
ORF1ab/nsp7	50	E50G	gAa	gGa	27	27	AY.84	0.011811
ORF1ab/nsp7	50	E50G	gAa	gGa	26	26	AY.4.2	0.000564
ORF1ab/nsp7	50	E50G	gAa	gGa	21	21	B.1.1.317	0.008646
ORF1ab/nsp7	50	E50G	gAa	gGa	21	21	B.1.1.369	0.009371
ORF1ab/nsp7	50	E50G	gAa	gGa	19	19	B.1.1	0.000345
ORF1ab/nsp7	50	E50G	gAa	gGa	17	17	B.1.429	0.0004
ORF1ab/nsp7	50	E50G	gAa	gGa	15	15	AY.39	0.000371
ORF1ab/nsp7	50	E50G	gAa	gGa	15	15	B.1.1.519	0.000596
ORF1ab/nsp7	50	E50G	gAa	gGa	13	13	AY.102	0.000345
ORF1ab/nsp7	50	E50G	gAa	gGa	13	13	AY.20	0.000505
ORF1ab/nsp7	50	E50G	gAa	gGa	12	12	AY.5	0.000248
ORF1ab/nsp7	50	E50G	gAa	gGa	12	12	B.1.258	0.000799
ORF1ab/nsp7	50	E50G	gAa	gGa	11	11	AY.27	0.000712
ORF1ab/nsp7	50	E50G	gAa	gGa	11	11	AY.4.2.1	0.001639
ORF1ab/nsp7	50	E50G	gAa	gGa	10	10	AY.29	0.000158
ORF1ab/nsp7	50	E50G	gAa	gGa	10	10	U.2	0.087719
ORF1ab/nsp7	50	E50G	gAa	gGa	8	8	AY.45	0.000973
ORF1ab/nsp7	50	E50G	gAa	gGa	8	8	B.1.160	0.00025
ORF1ab/nsp7	50	E50G	gAa	gGa	7	7	AY.118	0.000439
ORF1ab/nsp7	50	E50G	gAa	gGa	7	7	AY.6	0.000288
ORF1ab/nsp7	50	E50G	gAa	gGa	7	7	B.1.177.79	0.016393
ORF1ab/nsp7	50	E50G	gAa	gGa	7	7	B.1.221	0.000497
ORF1ab/nsp7	50	E50G	gAa	gGa	6	6	AE.8	0.002934
ORF1ab/nsp7	50	E50G	gAa	gGa	6	6	AY.47	0.000187
ORF1ab/nsp7	50	E50G	gAa	gGa	6	6	AY.75	0.000336
ORF1ab/nsp7	50	E50G	gAa	gGa	5	5	B	0.000639
ORF1ab/nsp7	50	E50G	gAa	gGa	5	5	B.1.1.377	0.006906
ORF1ab/nsp7	50	E50G	gAa	gGa	5	5	B.1.177.86	0.000917
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	AY.23	0.000279
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	AY.39.1	0.000158
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	B.1.243	0.000278
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	B.1.36	0.000584
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	B.1.438.1	0.000429
ORF1ab/nsp7	50	E50G	gAa	gGa	4	4	B.1.596	0.000349
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	AY.119	0.000106
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	AY.46	0.000312
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	AY.85	0.001282
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	AY.98.1	0.000145
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	AY.99	0.003148
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.1.39	0.001529
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.177.7	0.000495
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.240	0.000647
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.351	0.000089
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.36.16	0.004274
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	B.1.561	0.001191
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	D.2	0.000225
ORF1ab/nsp7	50	E50G	gAa	gGa	3	3	P.2	0.00056
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.113	0.000285
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.120	0.000074
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.26	0.000057
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.32	0.001065
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.46.1	0.002053
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.46.4	0.000329
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.46.6	0.000144
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.74	0.000231
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.9	0.000135
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.9.1	0.000167
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.92	0.000575
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.98	0.000158
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	AY.99.2	0.000184
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.1.33	0.000842
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.1.448	0.004065
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.1.464	0.002946
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.1.63	0.000772
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.177.60	0.000437
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.177.8	0.001505
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.177.82	0.000955
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.258.11	0.000793
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.279	0.001027
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.346	0.002621
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.36.29	0.001035
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.400	0.000858
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.427	0.000101
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.466.2	0.000782
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.1.609	0.000959
ORF1ab/nsp7	50	E50G	gAa	gGa	2	2	B.3	0.001661
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	A.2.4	0.003367
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AD.2	0.000219
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.100	0.000046
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.108	0.001103
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.110	0.000113
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.117	0.000085
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.13	0.000161
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.14	0.000088
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.16.1	0.00047
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.34.1	0.00051
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.4.5	0.000107
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.5.4	0.000277
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.54	0.000095
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.56	0.001605
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.61	0.000105
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.70	0.000209
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.75.1	0.00018
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.9.2	0.000037
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.91	0.00073
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	AY.96	0.002075
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.153	0.001095
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.174	0.003378
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.200	0.007463
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.214	0.000055
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.222	0.000204
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.241	0.00207
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.289	0.002083
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.301	0.001179
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.306	0.000438
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.351	0.002793
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.354	0.004386
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.518	0.006329
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.1.70	0.000341
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.139	0.000733
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.157	0.002985
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.160.32	0.004292
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.12	0.000152
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.18	0.00116
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.4	0.000211
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.54	0.000606
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.58	0.001332
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.75	0.001041
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.81	0.000189
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.83	0.001481
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.177.87	0.000728
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.227	0.047619
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.258.4	0.003448
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.349	0.000715
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.36.10	0.004785
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.36.19	0.009259
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.36.22	0.001208
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.362	0.001541
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.428	0.00102
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.439	0.005917
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.508	0.025641
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.517	0.000427
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.546	0.003704
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.551	0.00129
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.557	0.05
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.564	0.000426
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.577	0.000687
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.597	0.00463
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.617.1	0.000129
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.1.621	0.000089
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.4.8	0.071429
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.6.6	0.000889
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	B.6.8	0.008264
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	N.9	0.005952
ORF1ab/nsp7	50	E50G	gAa	gGa	1	1	R.1	0.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.