CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp6 : Mut = M192I

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp6192M192IM3761InonsynatGatT5994290.71619411546-11548
ORF1ab/nsp6192M192IM3761InonsynatGatA5991660.27712911546-11548
ORF1ab/nsp6192M192IM3761InonsynatGatC59940.006677811546-11548

Details of the mutation M192I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp6192M192IatGatT429599All0.000082
ORF1ab/nsp6192M192IatGatA166599All0.000032
ORF1ab/nsp6192M192IatGatC4599All0.000001
ORF1ab/nsp6192M192IatGatT234234AD.10.962963
ORF1ab/nsp6192M192IatGatA3052B.1.1.70.000027
ORF1ab/nsp6192M192IatGatT2252B.1.1.70.00002
ORF1ab/nsp6192M192IatGatA3243AY.4.20.000694
ORF1ab/nsp6192M192IatGatT1143AY.4.20.000239
ORF1ab/nsp6192M192IatGatT3838B.1.1.2190.19
ORF1ab/nsp6192M192IatGatA3737B.1.177.430.054653
ORF1ab/nsp6192M192IatGatA1119AY.40.000017
ORF1ab/nsp6192M192IatGatT819AY.40.000012
ORF1ab/nsp6192M192IatGatT1718AY.430.000075
ORF1ab/nsp6192M192IatGatA118AY.430.000004
ORF1ab/nsp6192M192IatGatT1516AY.1030.000093
ORF1ab/nsp6192M192IatGatA116AY.1030.000006
ORF1ab/nsp6192M192IatGatT811B.1.617.20.00003
ORF1ab/nsp6192M192IatGatA211B.1.617.20.000008
ORF1ab/nsp6192M192IatGatC111B.1.617.20.000004
ORF1ab/nsp6192M192IatGatA910B.10.000082
ORF1ab/nsp6192M192IatGatT110B.10.000009
ORF1ab/nsp6192M192IatGatT99AY.250.000054
ORF1ab/nsp6192M192IatGatT77B.1.1.1910.033333
ORF1ab/nsp6192M192IatGatT36B.1.20.000026
ORF1ab/nsp6192M192IatGatA36B.1.20.000026
ORF1ab/nsp6192M192IatGatT350.166667
ORF1ab/nsp6192M192IatGatC250.111111
ORF1ab/nsp6192M192IatGatT35AY.440.000018
ORF1ab/nsp6192M192IatGatA25AY.440.000012
ORF1ab/nsp6192M192IatGatA35B.1.1770.00004
ORF1ab/nsp6192M192IatGatT25B.1.1770.000026
ORF1ab/nsp6192M192IatGatT34AY.1000.000138
ORF1ab/nsp6192M192IatGatA14AY.1000.000046
ORF1ab/nsp6192M192IatGatT24AY.9.20.000073
ORF1ab/nsp6192M192IatGatA24AY.9.20.000073
ORF1ab/nsp6192M192IatGatA34B.1.10.000054
ORF1ab/nsp6192M192IatGatT14B.1.10.000018
ORF1ab/nsp6192M192IatGatT34B.1.4270.000151
ORF1ab/nsp6192M192IatGatA14B.1.4270.00005
ORF1ab/nsp6192M192IatGatT23AY.1020.000053
ORF1ab/nsp6192M192IatGatA13AY.1020.000027
ORF1ab/nsp6192M192IatGatA33AY.330.0002
ORF1ab/nsp6192M192IatGatA33B.1.1.3710.03125
ORF1ab/nsp6192M192IatGatT33B.1.1.500.002037
ORF1ab/nsp6192M192IatGatA33B.1.1600.000094
ORF1ab/nsp6192M192IatGatT22AY.1190.000071
ORF1ab/nsp6192M192IatGatT22AY.30.00002
ORF1ab/nsp6192M192IatGatA22AY.46.40.000329
ORF1ab/nsp6192M192IatGatT22AY.46.50.000397
ORF1ab/nsp6192M192IatGatT22AY.980.000158
ORF1ab/nsp6192M192IatGatT22B.1.2210.000142
ORF1ab/nsp6192M192IatGatA12B.1.3510.00003
ORF1ab/nsp6192M192IatGatT12B.1.3510.00003
ORF1ab/nsp6192M192IatGatT22B.1.5770.001375
ORF1ab/nsp6192M192IatGatT12B.1.6370.000073
ORF1ab/nsp6192M192IatGatA12B.1.6370.000073
ORF1ab/nsp6192M192IatGatT12Q.10.000126
ORF1ab/nsp6192M192IatGatA12Q.10.000126
ORF1ab/nsp6192M192IatGatA11A.10.000282
ORF1ab/nsp6192M192IatGatA11A.2.20.001689
ORF1ab/nsp6192M192IatGatA11AY.1200.000037
ORF1ab/nsp6192M192IatGatT11AY.140.000088
ORF1ab/nsp6192M192IatGatT11AY.160.00038
ORF1ab/nsp6192M192IatGatT11AY.270.000065
ORF1ab/nsp6192M192IatGatA11AY.300.000396
ORF1ab/nsp6192M192IatGatT11AY.360.000148
ORF1ab/nsp6192M192IatGatA11AY.390.000025
ORF1ab/nsp6192M192IatGatA11AY.400.000964
ORF1ab/nsp6192M192IatGatT11AY.460.000104
ORF1ab/nsp6192M192IatGatA11AY.550.000917
ORF1ab/nsp6192M192IatGatT11AY.610.000105
ORF1ab/nsp6192M192IatGatT11AY.9.10.000084
ORF1ab/nsp6192M192IatGatT11AY.910.00073
ORF1ab/nsp6192M192IatGatA11B.1.1.1940.00495
ORF1ab/nsp6192M192IatGatT11B.1.1.2220.000204
ORF1ab/nsp6192M192IatGatT11B.1.1.3150.008475
ORF1ab/nsp6192M192IatGatT11B.1.1.3980.003226
ORF1ab/nsp6192M192IatGatA11B.1.1420.002899
ORF1ab/nsp6192M192IatGatA11B.1.160.260.002421
ORF1ab/nsp6192M192IatGatA11B.1.160.300.002976
ORF1ab/nsp6192M192IatGatT11B.1.177.210.000076
ORF1ab/nsp6192M192IatGatA11B.1.177.600.000218
ORF1ab/nsp6192M192IatGatT11B.1.351.30.000876
ORF1ab/nsp6192M192IatGatT11B.1.36.220.001208
ORF1ab/nsp6192M192IatGatC11B.1.3960.000706
ORF1ab/nsp6192M192IatGatT11B.1.4080.00369
ORF1ab/nsp6192M192IatGatT11B.1.5950.000261
ORF1ab/nsp6192M192IatGatT11P.10.000016
ORF1ab/nsp6192M192IatGatT11P.1.60.001946
ORF1ab/nsp6192M192IatGatA11P.20.000187
ORF1ab/nsp6192M192IatGatT11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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