CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp6 : Mut = F216L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp6216F216LF3785LnonsynttCttA1421010.71126811618-11620
ORF1ab/nsp6216F216LF3785LnonsynTtcCtc142390.27464811618-11620
ORF1ab/nsp6216F216LF3785LnonsynttCttG14220.014084511618-11620

Details of the mutation F216L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp6216F216LttCttA101142All0.000019
ORF1ab/nsp6216F216LTtcCtc39142All0.000007
ORF1ab/nsp6216F216LttCttG2142All0
ORF1ab/nsp6216F216LttCttA5555AY.200.002138
ORF1ab/nsp6216F216LttCttA816B.1.1.70.000007
ORF1ab/nsp6216F216LTtcCtc816B.1.1.70.000007
ORF1ab/nsp6216F216LTtcCtc88B.1.1.3060.003507
ORF1ab/nsp6216F216LttCttA77B.1.2580.000466
ORF1ab/nsp6216F216LttCttA66AY.1030.000037
ORF1ab/nsp6216F216LTtcCtc66AY.250.000036
ORF1ab/nsp6216F216LttCttA45P.1.140.000191
ORF1ab/nsp6216F216LTtcCtc15P.1.140.000048
ORF1ab/nsp6216F216LttCttA34AY.40.000005
ORF1ab/nsp6216F216LTtcCtc14AY.40.000002
ORF1ab/nsp6216F216LttCttA34B.1.4290.000071
ORF1ab/nsp6216F216LTtcCtc14B.1.4290.000024
ORF1ab/nsp6216F216LttCttA44P.10.000063
ORF1ab/nsp6216F216LTtcCtc33A.270.004967
ORF1ab/nsp6216F216LttCttA22AY.430.000009
ORF1ab/nsp6216F216LttCttA22AY.98.10.000097
ORF1ab/nsp6216F216LTtcCtc22B.10.000018
ORF1ab/nsp6216F216LttCttA12B.1.20.000009
ORF1ab/nsp6216F216LTtcCtc12B.1.20.000009
ORF1ab/nsp6216F216LTtcCtc12B.1.617.20.000004
ORF1ab/nsp6216F216LttCttA12B.1.617.20.000004
ORF1ab/nsp6216F216LttCttA11AY.1180.000063
ORF1ab/nsp6216F216LTtcCtc11AY.140.000088
ORF1ab/nsp6216F216LttCttA11AY.260.000028
ORF1ab/nsp6216F216LTtcCtc11AY.320.000532
ORF1ab/nsp6216F216LttCttA11AY.450.000122
ORF1ab/nsp6216F216LttCttA11AY.50.000021
ORF1ab/nsp6216F216LTtcCtc11AY.590.00053
ORF1ab/nsp6216F216LTtcCtc11AY.610.000105
ORF1ab/nsp6216F216LTtcCtc11B.1.10.000018
ORF1ab/nsp6216F216LTtcCtc11B.1.1.1590.004673
ORF1ab/nsp6216F216LttCttG11B.1.1.3160.000925
ORF1ab/nsp6216F216LttCttG11B.1.3510.00003
ORF1ab/nsp6216F216LttCttA11B.1.3970.004854
ORF1ab/nsp6216F216LTtcCtc11B.1.5380.008065

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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