CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp6 : CodonNum = 274
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp6 | 274 | K274K | K3843K | syn | aaA | aaG | 377 | 377 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274R | K3843R | nonsyn | aAa | aGa | 189 | 189 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274N | K3843N | nonsyn | aaA | aaC | 30 | 17 | 0.566667 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274N | K3843N | nonsyn | aaA | aaT | 30 | 13 | 0.433333 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274del | K3843del | del | AAA | --- | 17 | 17 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274X | K3843X | nonsyn | Aaa | Taa | 8 | 7 | 0.875 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274X | K3843X | nonsyn | AAa | TGa | 8 | 1 | 0.125 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274E | K3843E | nonsyn | Aaa | Gaa | 6 | 6 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274I | K3843I | nonsyn | aAa | aTa | 3 | 3 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274del1 | K3843del1 | del | Aaa | -aa | 3 | 3 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274L | K3843L | nonsyn | AAa | CTa | 2 | 1 | 0.5 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274L | K3843L | nonsyn | AAa | TTa | 2 | 1 | 0.5 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274T | K3843T | nonsyn | aAa | aCa | 1 | 1 | 1 | 11792-11794 |
| ORF1ab/nsp6 | 274 | K274Q | K3843Q | nonsyn | Aaa | Caa | 1 | 1 | 1 | 11792-11794 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 377 | 377 | All | 0.000072 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 189 | 189 | All | 0.000036 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 118 | 118 | B.1.2 | 0.001039 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 111 | 111 | B.1.1.7 | 0.000099 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 88 | 88 | B.1.1.7 | 0.000079 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 50 | 50 | AY.42 | 0.002012 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 17 | 30 | All | 0.000003 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 13 | 30 | All | 0.000002 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 17 | 17 | All | 0.000003 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 17 | 17 | B.1.160 | 0.00053 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 15 | 15 | B.1.1 | 0.000272 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 15 | 15 | B.1.1.330 | 0.9375 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 14 | 14 | AY.103 | 0.000087 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 14 | 14 | AY.4 | 0.000022 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 9 | 9 | AY.100 | 0.000414 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 7 | 9 | AY.4 | 0.000011 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 2 | 9 | AY.4 | 0.000003 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 9 | 9 | B.1.617.2 | 0.000034 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 7 | 8 | All | 0.000001 |
| ORF1ab/nsp6 | 274 | K274X | AAa | TGa | 1 | 8 | All | 0 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 7 | 7 | AY.26 | 0.000198 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 6 | 6 | All | 0.000001 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 6 | 6 | P.1 | 0.000095 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 5 | 5 | AY.116 | 0.001434 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 5 | 5 | AY.43 | 0.000022 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 5 | 5 | AY.43 | 0.000022 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 4 | 4 | AY.3 | 0.00004 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 4 | 4 | AY.36 | 0.000593 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 4 | 4 | B.1 | 0.000037 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 4 | 4 | B.1.1.432 | 0.005063 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp6 | 274 | K274I | aAa | aTa | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp6 | 274 | K274del1 | Aaa | -aa | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 2 | 3 | AY.3 | 0.00002 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 3 | AY.3 | 0.00001 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 3 | 3 | AY.3.1 | 0.000256 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 2 | 3 | AY.5 | 0.000041 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 3 | AY.5 | 0.000021 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 3 | 3 | B.1 | 0.000027 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 2 | 3 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 3 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 3 | 3 | B.1.470 | 0.004213 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 2 | 2 | 0.111111 | |
| ORF1ab/nsp6 | 274 | K274L | AAa | TTa | 1 | 2 | All | 0 |
| ORF1ab/nsp6 | 274 | K274L | AAa | CTa | 1 | 2 | All | 0 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | AY.44 | 0.000012 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | AY.9.2 | 0.000073 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | B.1.400 | 0.000858 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 2 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 2 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | A.19 | 0.009434 |
| ORF1ab/nsp6 | 274 | K274T | aAa | aCa | 1 | 1 | All | 0 |
| ORF1ab/nsp6 | 274 | K274Q | Aaa | Caa | 1 | 1 | All | 0 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AU.3 | 0.00211 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp6 | 274 | K274I | aAa | aTa | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp6 | 274 | K274X | AAa | TGa | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.51 | 0.000909 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaC | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | AY.7.2 | 0.000559 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.1.186 | 0.003436 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | B.1.1.241 | 0.00207 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 1 | 1 | B.1.1.39 | 0.00051 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.1.53 | 0.013699 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.1.8 | 0.003584 |
| ORF1ab/nsp6 | 274 | K274T | aAa | aCa | 1 | 1 | B.1.111 | 0.001175 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | B.1.160.14 | 0.002119 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp6 | 274 | K274L | AAa | TTa | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.177.86 | 0.000183 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.177.9 | 0.001332 |
| ORF1ab/nsp6 | 274 | K274X | Aaa | Taa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp6 | 274 | K274I | aAa | aTa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp6 | 274 | K274del1 | Aaa | -aa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp6 | 274 | K274L | AAa | CTa | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.564.1 | 0.001577 |
| ORF1ab/nsp6 | 274 | K274del1 | Aaa | -aa | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp6 | 274 | K274Q | Aaa | Caa | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274del1 | Aaa | -aa | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp6 | 274 | K274E | Aaa | Gaa | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp6 | 274 | K274I | aAa | aTa | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | B.29 | 0.003509 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp6 | 274 | K274N | aaA | aaT | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp6 | 274 | K274del | AAA | --- | 1 | 1 | N.4 | 0.004255 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp6 | 274 | K274R | aAa | aGa | 1 | 1 | P.1.16 | 0.000374 |
| ORF1ab/nsp6 | 274 | K274K | aaA | aaG | 1 | 1 | P.1.7 | 0.000319 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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