CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp6 : CodonNum = 270 & Codon = aGa
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp6 | 270 | K270R | K3839R | nonsyn | aAa | aGa | 4883 | 4881 | 0.99959 | 11780-11782 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4881 | 4883 | All | 0.000934 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4194 | 4195 | B.1.177.4 | 0.885184 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 191 | 191 | AY.4 | 0.000297 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 125 | 125 | AY.103 | 0.000776 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 59 | 59 | B.1.1.7 | 0.000053 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 31 | 31 | B.1.177 | 0.000408 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 25 | 25 | B.1 | 0.000229 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 23 | 23 | AY.46.1 | 0.023614 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 19 | 19 | B.1.617.2 | 0.000072 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 18 | 18 | AY.25 | 0.000108 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 17 | 17 | Q.3 | 0.002466 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 12 | 13 | B.1.1 | 0.000218 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 12 | 12 | P.1 | 0.000189 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 10 | 10 | B.1.2 | 0.000088 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 8 | 8 | AY.43 | 0.000035 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 8 | 8 | B.1.429 | 0.000188 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 7 | 7 | AY.75 | 0.000392 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 6 | 6 | AY.14 | 0.000528 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 5 | 5 | AY.100 | 0.00023 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 5 | 5 | AY.102 | 0.000133 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 5 | 5 | AY.3 | 0.00005 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | AY.119 | 0.000141 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | AY.4.2 | 0.000087 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | B.1.1.141 | 0.008048 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | B.1.160 | 0.000125 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | B.1.258.3 | 0.0067 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | B.1.511 | 0.137931 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 4 | 4 | B.40 | 0.001457 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 3 | 3 | AY.20 | 0.000117 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 3 | 3 | B.1.1.391 | 0.025641 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.39 | 0.000049 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.42 | 0.00008 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.44 | 0.000012 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.45 | 0.000243 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | B.1.177.56 | 0.001335 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | B.1.311 | 0.000549 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | B.1.36 | 0.000292 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 2 | 2 | B.1.617.1 | 0.000258 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.111 | 0.000183 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.29.1 | 0.000221 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.35 | 0.000233 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.269 | 0.001353 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.27 | 0.00565 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.315 | 0.008475 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.177.19 | 0.001431 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.177.65 | 0.000665 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.36.16 | 0.001425 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.36.39 | 0.002217 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.544 | 0.006024 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | C.14 | 0.004329 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | C.30 | 0.001727 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp6 | 270 | K270R | aAa | aGa | 1 | 1 | Q.1 | 0.000126 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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