CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : Mut = S81F
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 81 | S81F | S3344F | nonsyn | tCt | tTt | 1183 | 1182 | 0.999155 | 10295-10297 |
| ORF1ab/nsp5A-B | 81 | S81F | S3344F | nonsyn | tCT | tTC | 1183 | 1 | 0.000845309 | 10295-10297 |
Details of the mutation S81F within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1182 | 1183 | All | 0.000226 |
| ORF1ab/nsp5A-B | 81 | S81F | tCT | tTC | 1 | 1183 | All | 0 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 261 | 261 | B.1.1.7 | 0.000234 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 119 | 119 | AY.4 | 0.000185 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 102 | 102 | B.1.221 | 0.007245 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 69 | 69 | B.1.177 | 0.000909 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 34 | 34 | B.1.1.449 | 0.772727 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 32 | 32 | P.1 | 0.000504 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 31 | 31 | B.1.36.8 | 0.031 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 30 | 30 | B.1.617.2 | 0.000113 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 27 | 27 | AY.44 | 0.000164 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 24 | 24 | B.1 | 0.00022 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 22 | 22 | AY.43 | 0.000097 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 21 | 21 | A.2.5 | 0.010479 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 21 | 21 | B.1.1.214 | 0.001165 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 21 | 21 | P.1.12 | 0.010165 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 19 | 19 | AY.103 | 0.000118 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 19 | 19 | AY.4.5 | 0.002042 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 18 | 18 | AY.14 | 0.001584 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 18 | 18 | B.1.1 | 0.000327 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 16 | 16 | AY.118 | 0.001002 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 15 | 15 | B.1.128 | 0.00953 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 14 | 14 | AY.39 | 0.000346 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 14 | 14 | B.1.237 | 0.069652 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 13 | 13 | AY.6 | 0.000535 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 9 | 9 | AY.102 | 0.000239 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 7 | 7 | B.1.351 | 0.000208 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 7 | 7 | B.1.36 | 0.001021 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 7 | 7 | B.1.637 | 0.000512 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | AY.119 | 0.000212 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | AY.25 | 0.000036 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | AY.3 | 0.00006 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | AY.34 | 0.000582 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | B.1.157 | 0.01791 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | B.1.526 | 0.000141 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 6 | 6 | B.1.621.1 | 0.003035 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | AY.100 | 0.00023 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | AY.20 | 0.000194 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | AY.47 | 0.000156 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | B.1.1.519 | 0.000199 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | B.1.177.81 | 0.000947 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | B.1.2 | 0.000044 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 5 | 5 | B.1.258.17 | 0.00052 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 4 | 0.166667 | |
| ORF1ab/nsp5A-B | 81 | S81F | tCT | tTC | 1 | 4 | 0.055556 | |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 4 | 4 | AY.75 | 0.000224 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 4 | 4 | B.1.621 | 0.000354 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | B.1.1.33 | 0.001263 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | B.1.177.86 | 0.00055 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | B.1.206 | 0.002447 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | B.1.429 | 0.000071 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | P.1.15 | 0.000697 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 3 | 3 | P.1.17 | 0.000485 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | AY.33 | 0.000134 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | AY.36 | 0.000296 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | AZ.2 | 0.001642 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.1.231 | 0.006192 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.1.25 | 0.001137 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.177.21 | 0.000153 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.223 | 0.005556 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.36.29 | 0.001035 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.367 | 0.001585 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.462 | 0.014493 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | C.37 | 0.000232 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | Q.1 | 0.000253 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 2 | 2 | Q.8 | 0.00033 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.19 | 0.00114 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.46.5 | 0.000198 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.220 | 0.001859 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.265 | 0.003155 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.291 | 0.000742 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.301 | 0.001179 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.311 | 0.000358 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.318 | 0.000302 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.348 | 0.000796 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.411 | 0.014706 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.147 | 0.000756 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.160.9 | 0.007194 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.177.60 | 0.000218 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.177.63 | 0.002703 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.177.75 | 0.001041 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.177.77 | 0.000726 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.199 | 0.004132 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.36.36 | 0.000602 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.36.9 | 0.003215 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.366 | 0.004878 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.560 | 0.00463 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | B.1.93 | 0.000934 |
| ORF1ab/nsp5A-B | 81 | S81F | tCt | tTt | 1 | 1 | P.7 | 0.004367 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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