CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : Mut = L232F

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp5A-B232L232FL3495FnonsynCttTtt10001000110748-10750

Details of the mutation L232F within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp5A-B232L232FCttTtt10001000All0.000191
ORF1ab/nsp5A-B232L232FCttTtt205205B.1.1.70.000184
ORF1ab/nsp5A-B232L232FCttTtt113113B.1.20.000995
ORF1ab/nsp5A-B232L232FCttTtt8282B.1.5960.007145
ORF1ab/nsp5A-B232L232FCttTtt8080AY.40.000125
ORF1ab/nsp5A-B232L232FCttTtt7373B.1.351.20.022088
ORF1ab/nsp5A-B232L232FCttTtt4040B.1.617.20.000151
ORF1ab/nsp5A-B232L232FCttTtt3535AY.430.000155
ORF1ab/nsp5A-B232L232FCttTtt3434B.1.1.1650.523077
ORF1ab/nsp5A-B232L232FCttTtt2929B.1.2650.036849
ORF1ab/nsp5A-B232L232FCttTtt2323AY.470.000715
ORF1ab/nsp5A-B232L232FCttTtt2020B.1.1770.000263
ORF1ab/nsp5A-B232L232FCttTtt1818AY.4.20.00039
ORF1ab/nsp5A-B232L232FCttTtt1818P.10.000284
ORF1ab/nsp5A-B232L232FCttTtt1515AY.440.000091
ORF1ab/nsp5A-B232L232FCttTtt1515B.1.5260.000353
ORF1ab/nsp5A-B232L232FCttTtt1414AY.420.000563
ORF1ab/nsp5A-B232L232FCttTtt1313AY.250.000078
ORF1ab/nsp5A-B232L232FCttTtt1111AY.30.000109
ORF1ab/nsp5A-B232L232FCttTtt1010B.10.000092
ORF1ab/nsp5A-B232L232FCttTtt88B.1.3510.000238
ORF1ab/nsp5A-B232L232FCttTtt77P.1.140.000335
ORF1ab/nsp5A-B232L232FCttTtt66B.1.221.20.024096
ORF1ab/nsp5A-B232L232FCttTtt66B.1.4290.000141
ORF1ab/nsp5A-B232L232FCttTtt66B.1.6370.000438
ORF1ab/nsp5A-B232L232FCttTtt55A0.001935
ORF1ab/nsp5A-B232L232FCttTtt44AY.1030.000025
ORF1ab/nsp5A-B232L232FCttTtt44AY.1210.000541
ORF1ab/nsp5A-B232L232FCttTtt44AY.460.000416
ORF1ab/nsp5A-B232L232FCttTtt33A.270.004967
ORF1ab/nsp5A-B232L232FCttTtt33AY.1020.00008
ORF1ab/nsp5A-B232L232FCttTtt33AY.130.000483
ORF1ab/nsp5A-B232L232FCttTtt33B.1.10.000054
ORF1ab/nsp5A-B232L232FCttTtt33B.1.1.4340.001046
ORF1ab/nsp5A-B232L232FCttTtt33B.1.1.5190.000119
ORF1ab/nsp5A-B232L232FCttTtt33B.1.177.60.00293
ORF1ab/nsp5A-B232L232FCttTtt33B.1.3890.003006
ORF1ab/nsp5A-B232L232FCttTtt22A.2.50.000998
ORF1ab/nsp5A-B232L232FCttTtt22AY.1050.001286
ORF1ab/nsp5A-B232L232FCttTtt22AY.1130.000285
ORF1ab/nsp5A-B232L232FCttTtt22AY.260.000057
ORF1ab/nsp5A-B232L232FCttTtt22AY.290.000032
ORF1ab/nsp5A-B232L232FCttTtt22AY.330.000134
ORF1ab/nsp5A-B232L232FCttTtt22AY.39.10.000079
ORF1ab/nsp5A-B232L232FCttTtt22AY.510.001818
ORF1ab/nsp5A-B232L232FCttTtt22B.1.1.2160.001781
ORF1ab/nsp5A-B232L232FCttTtt22B.1.2210.000142
ORF1ab/nsp5A-B232L232FCttTtt22B.1.351.50.001199
ORF1ab/nsp5A-B232L232FCttTtt22B.1.6280.000705
ORF1ab/nsp5A-B232L232FCttTtt22C.360.001821
ORF1ab/nsp5A-B232L232FCttTtt11AY.1000.000046
ORF1ab/nsp5A-B232L232FCttTtt11AY.1140.000231
ORF1ab/nsp5A-B232L232FCttTtt11AY.1180.000063
ORF1ab/nsp5A-B232L232FCttTtt11AY.1190.000035
ORF1ab/nsp5A-B232L232FCttTtt11AY.270.000065
ORF1ab/nsp5A-B232L232FCttTtt11AY.3.10.000085
ORF1ab/nsp5A-B232L232FCttTtt11AY.360.000148
ORF1ab/nsp5A-B232L232FCttTtt11AY.370.000316
ORF1ab/nsp5A-B232L232FCttTtt11AY.4.50.000107
ORF1ab/nsp5A-B232L232FCttTtt11AY.50.000021
ORF1ab/nsp5A-B232L232FCttTtt11AY.590.00053
ORF1ab/nsp5A-B232L232FCttTtt11AY.640.000595
ORF1ab/nsp5A-B232L232FCttTtt11AY.650.000533
ORF1ab/nsp5A-B232L232FCttTtt11AY.70.000196
ORF1ab/nsp5A-B232L232FCttTtt11AY.740.000116
ORF1ab/nsp5A-B232L232FCttTtt11AY.750.000056
ORF1ab/nsp5A-B232L232FCttTtt11AY.75.10.00018
ORF1ab/nsp5A-B232L232FCttTtt11AY.850.000427
ORF1ab/nsp5A-B232L232FCttTtt11AY.920.000287
ORF1ab/nsp5A-B232L232FCttTtt11AY.950.000761
ORF1ab/nsp5A-B232L232FCttTtt11AY.99.20.000092
ORF1ab/nsp5A-B232L232FCttTtt11AZ.20.000821
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1.10.000327
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1.280.000311
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1.450.014085
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1.500.000679
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1.700.000341
ORF1ab/nsp5A-B232L232FCttTtt11B.1.1600.000031
ORF1ab/nsp5A-B232L232FCttTtt11B.1.177.810.000189
ORF1ab/nsp5A-B232L232FCttTtt11B.1.220.001318
ORF1ab/nsp5A-B232L232FCttTtt11B.1.2390.001221
ORF1ab/nsp5A-B232L232FCttTtt11B.1.2400.000216
ORF1ab/nsp5A-B232L232FCttTtt11B.1.3110.000275
ORF1ab/nsp5A-B232L232FCttTtt11B.1.360.000146
ORF1ab/nsp5A-B232L232FCttTtt11B.1.3610.001289
ORF1ab/nsp5A-B232L232FCttTtt11B.1.3970.004854
ORF1ab/nsp5A-B232L232FCttTtt11B.1.4270.00005
ORF1ab/nsp5A-B232L232FCttTtt11B.1.4870.019608
ORF1ab/nsp5A-B232L232FCttTtt11B.1.5030.002488
ORF1ab/nsp5A-B232L232FCttTtt11B.1.5440.006024
ORF1ab/nsp5A-B232L232FCttTtt11B.1.5770.000687
ORF1ab/nsp5A-B232L232FCttTtt11B.1.5950.000261
ORF1ab/nsp5A-B232L232FCttTtt11B.1.6090.000479
ORF1ab/nsp5A-B232L232FCttTtt11B.1.619.10.000641
ORF1ab/nsp5A-B232L232FCttTtt11B.1.6230.000536
ORF1ab/nsp5A-B232L232FCttTtt11B.1.6250.002353
ORF1ab/nsp5A-B232L232FCttTtt11C.350.000774
ORF1ab/nsp5A-B232L232FCttTtt11C.36.30.000567
ORF1ab/nsp5A-B232L232FCttTtt11P.1.70.000319
ORF1ab/nsp5A-B232L232FCttTtt11Q.10.000126
ORF1ab/nsp5A-B232L232FCttTtt11Q.80.000165
ORF1ab/nsp5A-B232L232FCttTtt11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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