CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : Mut = G71S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 71 | G71S | G3334S | nonsyn | Ggt | Agt | 6215 | 6214 | 0.999839 | 10265-10267 |
| ORF1ab/nsp5A-B | 71 | G71S | G3334S | nonsyn | GgT | AgC | 6215 | 1 | 0.000160901 | 10265-10267 |
Details of the mutation G71S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 6214 | 6215 | All | 0.001189 |
| ORF1ab/nsp5A-B | 71 | G71S | GgT | AgC | 1 | 6215 | All | 0 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2878 | 2878 | B.1.1.70 | 0.981583 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 838 | 838 | B.1.1.301 | 0.988208 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 662 | 662 | AP.1 | 0.993994 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 523 | 523 | B.1.1 | 0.009488 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 347 | 347 | B.1 | 0.003178 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 176 | 176 | B.1.1.27 | 0.99435 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 92 | 92 | B.1.1.300 | 0.989247 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 81 | 81 | B.1.1.513 | 1 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 79 | 79 | B.1.1.299 | 0.963415 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 61 | 61 | B.1.177 | 0.000803 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 50 | 50 | AY.4 | 0.000078 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 34 | 34 | AY.43 | 0.000151 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 34 | 34 | B.1.1.512 | 0.971429 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 32 | 32 | B.1.1.7 | 0.000029 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 23 | 23 | B.1.160 | 0.000717 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 19 | 19 | B.1.1.514 | 0.730769 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 16 | 16 | B.1.221 | 0.001137 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 15 | 15 | AY.116 | 0.004302 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 14 | 14 | B | 0.001789 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 12 | 12 | AY.98.1 | 0.000581 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 10 | 10 | AY.103 | 0.000062 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 10 | 10 | AY.20 | 0.000389 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 10 | 10 | B.1.609 | 0.004794 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 8 | 8 | B.1.160.32 | 0.034335 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 8 | 8 | B.1.177.44 | 0.004152 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 8 | 8 | B.1.258 | 0.000532 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 8 | 8 | C.35 | 0.006192 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 7 | 7 | AY.102 | 0.000186 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 7 | 7 | AY.42 | 0.000282 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 6 | 6 | AY.25 | 0.000036 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 5 | 5 | AY.39 | 0.000124 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 5 | 5 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 5 | 5 | C.36.3 | 0.002836 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 4 | 4 | AY.46 | 0.000416 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 4 | 4 | B.1.1.44 | 0.009639 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AD.2 | 0.000657 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AY.34 | 0.000291 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AY.4.2 | 0.000065 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AY.44 | 0.000018 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AY.5.4 | 0.00083 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | AY.9.1 | 0.000251 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.1.10 | 0.003344 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.1.170 | 0.003741 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.170 | 0.012931 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.177.75 | 0.003122 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.2 | 0.000026 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.258.11 | 0.001189 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.367 | 0.002377 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 3 | 3 | B.1.429 | 0.000071 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 2 | 0.055556 | |
| ORF1ab/nsp5A-B | 71 | G71S | GgT | AgC | 1 | 2 | 0.055556 | |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | AY.46.1 | 0.002053 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | AY.54 | 0.000191 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | AY.67 | 0.000929 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.1.1 | 0.000653 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.1.174 | 0.006757 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.1.372 | 0.001377 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.1.39 | 0.001019 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.1.409 | 0.005666 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | B.1.177.86 | 0.000367 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 2 | 2 | K.1 | 0.047619 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.51 | 0.000909 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.7.2 | 0.000559 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.144 | 0.028571 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.152 | 0.04 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.157 | 0.000913 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.161 | 0.003534 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.193 | 0.111111 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.221 | 0.010101 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.254 | 0.011236 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.277 | 0.000759 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.305 | 0.003861 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.420 | 0.001006 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.432 | 0.001266 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.56 | 0.017857 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.1.98 | 0.018519 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.142 | 0.002899 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.146 | 0.004237 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.160.9 | 0.007194 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.177.31 | 0.011494 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.214 | 0.003663 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.214.2 | 0.0006 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.236 | 0.002053 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.284 | 0.013158 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.355 | 0.011111 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.362 | 0.001541 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.416 | 0.001269 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.416.1 | 0.001563 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.437 | 0.020833 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.473 | 0.019231 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.597 | 0.00463 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.78 | 0.008547 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.1.94 | 0.027027 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | B.29 | 0.003509 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | C.27 | 0.018519 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | C.30 | 0.001727 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | C.37.1 | 0.002618 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | C.5 | 0.090909 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp5A-B | 71 | G71S | Ggt | Agt | 1 | 1 | P.1.14 | 0.000048 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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