CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : Mut = D248D
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 248 | D248D | D3511D | syn | gaC | gaT | 3117 | 3117 | 1 | 10796-10798 |
Details of the mutation D248D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3117 | 3117 | All | 0.000596 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2083 | 2083 | B.1.561 | 0.826915 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 197 | 197 | B.1.1.7 | 0.000176 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 105 | 105 | AY.4 | 0.000163 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 104 | 104 | B.1 | 0.000953 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 82 | 82 | AY.26 | 0.002321 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 68 | 68 | B.1.569 | 0.985507 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 52 | 52 | B.1.2 | 0.000458 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 34 | 34 | AY.103 | 0.000211 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 27 | 27 | B.1.617.2 | 0.000102 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 25 | 25 | AY.3 | 0.000249 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 23 | 23 | P.1.14 | 0.001099 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 21 | 21 | AY.25 | 0.000126 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 18 | 18 | B.1.177 | 0.000237 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 16 | 16 | B.1.629 | 0.213333 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 12 | 12 | B.1.1 | 0.000218 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 12 | 12 | B.1.160 | 0.000374 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 12 | 12 | B.1.240 | 0.002587 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 11 | 11 | AY.43 | 0.000049 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 11 | 11 | B.1.1.519 | 0.000437 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 9 | 9 | AY.20 | 0.00035 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 9 | 9 | P.1 | 0.000142 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 8 | 8 | B.1.630 | 0.041885 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 7 | 7 | AY.44 | 0.000043 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 6 | 6 | AY.23 | 0.000418 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 6 | 6 | AY.46 | 0.000624 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 6 | 6 | B.1.177.81 | 0.001136 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 6 | 6 | B.1.429 | 0.000141 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | AY.100 | 0.00023 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | AY.111 | 0.000916 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | B.1.243 | 0.000348 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | B.1.258.17 | 0.00052 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | B.1.351 | 0.000149 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | B.1.36.29 | 0.002587 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 5 | 5 | B.1.582 | 0.002453 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 4 | 4 | B.1.1.222 | 0.000816 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 4 | 4 | B.1.1.306 | 0.001754 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 4 | 4 | B.1.618 | 0.016129 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3 | 3 | AY.102 | 0.00008 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3 | 3 | B.1.621 | 0.000266 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 3 | 3 | B.1.76 | 0.034091 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | AY.117 | 0.000169 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | AY.13 | 0.000322 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | AY.88 | 0.001768 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.1.207 | 0.002364 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.139 | 0.001466 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.177.44 | 0.001038 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.221 | 0.000142 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.232 | 0.001075 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.311 | 0.000549 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.369 | 0.00057 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.1.466.2 | 0.000782 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 2 | 2 | B.31 | 0.007463 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | A.3 | 0.002096 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.35 | 0.000233 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.58 | 0.000907 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.65 | 0.000533 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.95 | 0.000761 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.1.382 | 0.035714 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.1.409 | 0.002833 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.177.30 | 0.002513 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.222 | 0.001692 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.247 | 0.014925 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.258.11 | 0.000396 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.258.22 | 0.002667 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.315 | 0.006061 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.348 | 0.018182 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.36.8 | 0.001 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.370 | 0.008 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.396 | 0.000706 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.460 | 0.017857 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.555 | 0.022222 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.565 | 0.00081 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.1.610 | 0.003546 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | B.3 | 0.000831 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | P.1.7 | 0.000319 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | P.2 | 0.000187 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | P.3 | 0.001595 |
| ORF1ab/nsp5A-B | 248 | D248D | gaC | gaT | 1 | 1 | Q.3 | 0.000145 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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