CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : CodonNum = 266 & Codon = gTt
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 266 | A266V | A3529V | nonsyn | gCt | gTt | 768 | 767 | 0.998698 | 10850-10852 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 767 | 768 | All | 0.000147 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 319 | 319 | B.1.319 | 0.972561 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 132 | 132 | B.1.1.7 | 0.000118 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 92 | 92 | B.1 | 0.000843 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 20 | 20 | AY.4 | 0.000031 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 17 | 17 | B.1.617.2 | 0.000064 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 13 | 13 | AY.44 | 0.000079 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 13 | 13 | B.1.1 | 0.000236 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 8 | 8 | AY.25 | 0.000048 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 6 | 6 | AY.34 | 0.000582 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 6 | 6 | B.1.1.311 | 0.002149 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 6 | 6 | B.1.2 | 0.000053 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 6 | 6 | B.1.438.1 | 0.000644 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 5 | 5 | AY.26 | 0.000142 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 5 | 5 | B.1.177 | 0.000066 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 5 | 5 | B.1.177.21 | 0.000382 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 5 | 5 | B.1.258 | 0.000333 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 4 | 4 | B.1.1.306 | 0.001754 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 4 | 4 | B.1.1.519 | 0.000159 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 4 | 4 | B.1.177.32 | 0.005398 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 4 | 4 | B.1.526 | 0.000094 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | AY.103 | 0.000019 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | AY.119 | 0.000106 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | AY.3 | 0.00003 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | B.1.320 | 0.003736 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 3 | 3 | P.1 | 0.000047 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 2 | 0.055556 | |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | AY.43 | 0.000009 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | AY.90 | 0.001369 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B | 0.000256 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.1.39 | 0.001019 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.221 | 0.000142 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.306 | 0.011429 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.429 | 0.000047 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.568 | 0.002222 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | B.1.637 | 0.000146 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | A.9 | 0.045455 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AD.2 | 0.000219 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.107 | 0.000466 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.29.1 | 0.000221 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.63 | 0.000387 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | AZ.2 | 0.000821 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.198 | 0.001468 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.289 | 0.002083 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.336 | 0.016667 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.337 | 0.003597 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.416 | 0.000905 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.160.16 | 0.000929 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.177.12 | 0.000152 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.177.16 | 0.000664 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.258.7 | 0.001912 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.326 | 0.007576 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.333 | 0.010526 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.36.17 | 0.000494 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.381 | 0.007812 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.422 | 0.000812 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.434 | 0.052632 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.44 | 0.008333 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.465 | 0.003802 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.485 | 0.014925 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.565 | 0.00081 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp5A-B | 266 | A266V | gCt | gTt | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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