CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : CodonNum = 241 & Codon = ccG

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp5A-B	241	P241P	P3504P	syn	ccT	ccG	282	32	0.113475	10775-10777

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	32	282	All	0.000006
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	4	54	AY.43	0.000018
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	6	17	AY.4	0.000009
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	15	B.1.1.7	0.000001
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	11	AY.103	0.000006
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	11	11	AY.37	0.003477
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	6	B.1.617.2	0.000004
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	3	3	AY.113	0.000427
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	2	2	B.1.379	0.034483
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	1	AY.102	0.000027
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	1	AY.119	0.000035
ORF1ab/nsp5A-B	241	P241P	ccT	ccG	1	1	B.1.577	0.000687

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.