CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : CodonNum = 205
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 205 | L205V | L3468V | nonsyn | Tta | Gta | 5272 | 5271 | 0.99981 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205V | L3468V | nonsyn | TtA | GtG | 5272 | 1 | 0.000189681 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205L | L3468L | syn | ttA | ttG | 153 | 104 | 0.679739 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205L | L3468L | syn | Tta | Cta | 153 | 49 | 0.320261 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205del | L3468del | del | TTA | --- | 40 | 40 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205I | L3468I | nonsyn | Tta | Ata | 7 | 7 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205F | L3468F | nonsyn | ttA | ttT | 4 | 4 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205K | L3468K | nonsyn | TTa | AAa | 3 | 3 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205del2 | L3468del2 | del | TTA | --N | 2 | 1 | 0.5 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205del2 | L3468del2 | del | TTA | --W | 2 | 1 | 0.5 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205X | L3468X | nonsyn | tTa | tAa | 2 | 1 | 0.5 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205X | L3468X | nonsyn | tTa | tGa | 2 | 1 | 0.5 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205G | L3468G | nonsyn | TTa | GGa | 1 | 1 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205S | L3468S | nonsyn | tTa | tCa | 1 | 1 | 1 | 10667-10669 |
| ORF1ab/nsp5A-B | 205 | L205Y | L3468Y | nonsyn | tTA | tAT | 1 | 1 | 1 | 10667-10669 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 5271 | 5272 | All | 0.001008 |
| ORF1ab/nsp5A-B | 205 | L205V | TtA | GtG | 1 | 5272 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 5207 | 5208 | P.2 | 0.971818 |
| ORF1ab/nsp5A-B | 205 | L205V | TtA | GtG | 1 | 5208 | P.2 | 0.000187 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 104 | 153 | All | 0.00002 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 49 | 153 | All | 0.000009 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 40 | 40 | All | 0.000008 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 13 | 21 | AY.25 | 0.000078 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 8 | 21 | AY.25 | 0.000048 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 20 | 20 | B.1 | 0.000183 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 14 | 20 | B.1.1.7 | 0.000013 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 6 | 20 | B.1.1.7 | 0.000005 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 12 | 17 | B.1.617.2 | 0.000045 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 5 | 17 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 14 | 14 | B.1.258 | 0.000932 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 12 | 12 | B.1.1 | 0.000218 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 11 | 11 | B.1.1.7 | 0.00001 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 7 | 8 | AY.4 | 0.000011 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 8 | AY.4 | 0.000002 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 6 | 8 | AY.4.2 | 0.00013 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 2 | 8 | AY.4.2 | 0.000043 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 8 | 8 | B.1.177 | 0.000105 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 7 | 7 | All | 0.000001 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 7 | 7 | B.1.1.7 | 0.000006 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 4 | 6 | AY.43 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 2 | 6 | AY.43 | 0.000009 |
| ORF1ab/nsp5A-B | 205 | L205F | ttA | ttT | 4 | 4 | All | 0.000001 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 4 | 4 | AY.100 | 0.000184 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 4 | 4 | AY.103 | 0.000025 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 3 | 4 | AY.44 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 4 | AY.44 | 0.000006 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 4 | 4 | B.1.1.261 | 0.034483 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 4 | 4 | B.1.617.2 | 0.000015 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 4 | 4 | P.1.1 | 0.001271 |
| ORF1ab/nsp5A-B | 205 | L205K | TTa | AAa | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 3 | 3 | AY.4 | 0.000005 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 2 | 3 | B.1 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 3 | B.1 | 0.000009 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 3 | 3 | P.6 | 0.009434 |
| ORF1ab/nsp5A-B | 205 | L205F | ttA | ttT | 2 | 2 | 0.111111 | |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 2 | 2 | 0.111111 | |
| ORF1ab/nsp5A-B | 205 | L205K | TTa | AAa | 2 | 2 | 0.111111 | |
| ORF1ab/nsp5A-B | 205 | L205del2 | TTA | --W | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205del2 | TTA | --N | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205X | tTa | tGa | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205X | tTa | tAa | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 2 | AY.102 | 0.000027 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 2 | AY.102 | 0.000027 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 2 | 2 | AY.4.5 | 0.000215 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 2 | 2 | B.1.1.28 | 0.000622 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 2 | 2 | B.1.424 | 0.016129 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 2 | B.1.429 | 0.000024 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 2 | B.1.429 | 0.000024 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 2 | 2 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 2 | B.1.621 | 0.000089 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 2 | B.1.621 | 0.000089 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp5A-B | 205 | L205Y | tTA | tAT | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205S | tTa | tCa | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205G | TTa | GGa | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp5A-B | 205 | L205K | TTa | AAa | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp5A-B | 205 | L205del2 | TTA | --W | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp5A-B | 205 | L205S | tTa | tCa | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp5A-B | 205 | L205Y | tTA | tAT | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp5A-B | 205 | L205F | ttA | ttT | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp5A-B | 205 | L205G | TTa | GGa | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.1.128 | 0.007092 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.1.288 | 0.001916 |
| ORF1ab/nsp5A-B | 205 | L205X | tTa | tGa | 1 | 1 | B.1.1.300 | 0.010753 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.1.44 | 0.00241 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.1.521 | 0.005348 |
| ORF1ab/nsp5A-B | 205 | L205del2 | TTA | --N | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 1 | B.1.160.30 | 0.002976 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp5A-B | 205 | L205X | tTa | tAa | 1 | 1 | B.1.177.32 | 0.00135 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.177.76 | 0.002494 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.351.5 | 0.0006 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.407 | 0.035714 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 1 | B.1.416.1 | 0.001563 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.470 | 0.001404 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | B.1.6 | 0.017241 |
| ORF1ab/nsp5A-B | 205 | L205F | ttA | ttT | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.618 | 0.004032 |
| ORF1ab/nsp5A-B | 205 | L205I | Tta | Ata | 1 | 1 | B.1.621.1 | 0.000506 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 1 | B.1.633 | 0.041667 |
| ORF1ab/nsp5A-B | 205 | L205V | Tta | Gta | 1 | 1 | B.1.91 | 0.002075 |
| ORF1ab/nsp5A-B | 205 | L205L | Tta | Cta | 1 | 1 | B.4 | 0.002208 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | C.36 | 0.000911 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | N.4 | 0.004255 |
| ORF1ab/nsp5A-B | 205 | L205del | TTA | --- | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp5A-B | 205 | L205L | ttA | ttG | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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