CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp5A-B : CodonNum = 102
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp5A-B | 102 | K102K | K3365K | syn | aaG | aaA | 721 | 721 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102R | K3365R | nonsyn | aAg | aGg | 618 | 618 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102N | K3365N | nonsyn | aaG | aaT | 51 | 45 | 0.882353 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102N | K3365N | nonsyn | aaG | aaC | 51 | 6 | 0.117647 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102del | K3365del | del | AAG | --- | 43 | 43 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102E | K3365E | nonsyn | Aag | Gag | 3 | 3 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102X | K3365X | nonsyn | Aag | Tag | 2 | 2 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102M | K3365M | nonsyn | aAg | aTg | 2 | 2 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102T | K3365T | nonsyn | aAg | aCg | 2 | 2 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102S | K3365S | nonsyn | AAg | TCg | 2 | 1 | 0.5 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102S | K3365S | nonsyn | aAG | aGT | 2 | 1 | 0.5 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102del1 | K3365del1 | del | Aag | -ag | 2 | 1 | 0.5 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102del1 | K3365del1 | del | aAG | aG- | 2 | 1 | 0.5 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102C | K3365C | nonsyn | AAG | TGT | 1 | 1 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102del2 | K3365del2 | del | aAG | a-- | 1 | 1 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102V | K3365V | nonsyn | AAg | GTg | 1 | 1 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102L | K3365L | nonsyn | AAg | TTg | 1 | 1 | 1 | 10358-10360 |
| ORF1ab/nsp5A-B | 102 | K102Y | K3365Y | nonsyn | AaG | TaC | 1 | 1 | 1 | 10358-10360 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 721 | 721 | All | 0.000138 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 618 | 618 | All | 0.000118 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 518 | 518 | B.1.1.7 | 0.000464 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 260 | 260 | B.1.1.329 | 1 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 156 | 156 | B.1.1.389 | 0.945455 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 80 | 80 | B.1.1 | 0.001451 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 59 | 59 | B.1.1.328 | 1 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 45 | 51 | All | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaC | 6 | 51 | All | 0.000001 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 43 | 43 | All | 0.000008 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 43 | 43 | B.1.1.7 | 0.000038 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 40 | 40 | B.1 | 0.000366 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 18 | 18 | AY.26 | 0.00051 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 14 | 14 | B.1.619.1 | 0.00898 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 13 | 13 | B.1.177 | 0.000171 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 13 | 13 | B.1.617.2 | 0.000049 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 12 | 12 | B.1.1.7 | 0.000011 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 11 | 11 | B.1.351 | 0.000327 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 9 | 9 | AY.44 | 0.000055 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 7 | 7 | P.1 | 0.00011 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 7 | 7 | Q.8 | 0.001154 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 6 | 6 | AY.25 | 0.000036 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 6 | 6 | AY.4 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 6 | 6 | B.1.1.311 | 0.002149 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 6 | 6 | B.1.1.432 | 0.007595 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 6 | 6 | B.1.617.2 | 0.000023 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 5 | 5 | AY.4 | 0.000008 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 5 | 5 | B.1.526 | 0.000118 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 2 | 4 | 0.111111 | |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaC | 2 | 4 | 0.111111 | |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 4 | 4 | AY.43 | 0.000018 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 4 | 4 | B.1.1.7 | 0.000004 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 4 | 4 | B.1.617.2 | 0.000015 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaC | 4 | 4 | C.36 | 0.003643 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 4 | 4 | P.1 | 0.000063 |
| ORF1ab/nsp5A-B | 102 | K102E | Aag | Gag | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 3 | 3 | AY.102 | 0.00008 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 3 | 3 | AY.44 | 0.000018 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | 0.111111 | |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 2 | 2 | 0.111111 | |
| ORF1ab/nsp5A-B | 102 | K102X | Aag | Tag | 2 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102T | aAg | aCg | 2 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102M | aAg | aTg | 2 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102S | AAg | TCg | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102del1 | Aag | -ag | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102del1 | aAG | aG- | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102S | aAG | aGT | 1 | 2 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | AY.119 | 0.000071 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | AY.4 | 0.000003 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 2 | 2 | AY.43 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | AY.43 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 2 | 2 | AY.7.1 | 0.000225 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | AY.9.1 | 0.000167 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | B.1.243 | 0.000139 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | B.1.438.1 | 0.000215 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | B.1.609 | 0.000959 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 2 | 2 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 2 | 2 | B.1.621.1 | 0.001012 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 2 | 2 | Q.1 | 0.000253 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp5A-B | 102 | K102Y | AaG | TaC | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102V | AAg | GTg | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102C | AAG | TGT | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102del2 | aAG | a-- | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102L | AAg | TTg | 1 | 1 | All | 0 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp5A-B | 102 | K102L | AAg | TTg | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp5A-B | 102 | K102V | AAg | GTg | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp5A-B | 102 | K102del1 | Aag | -ag | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | AY.69 | 0.000187 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | AY.73 | 0.000665 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp5A-B | 102 | K102T | aAg | aCg | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp5A-B | 102 | K102E | Aag | Gag | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.1.277 | 0.000759 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1.1.39 | 0.00051 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1.1.420 | 0.001006 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1.1.523 | 0.001563 |
| ORF1ab/nsp5A-B | 102 | K102M | aAg | aTg | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp5A-B | 102 | K102X | Aag | Tag | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.1.86 | 0.035714 |
| ORF1ab/nsp5A-B | 102 | K102T | aAg | aCg | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp5A-B | 102 | K102E | Aag | Gag | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp5A-B | 102 | K102S | aAG | aGT | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1.177.18 | 0.00116 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.177.18 | 0.00116 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp5A-B | 102 | K102E | Aag | Gag | 1 | 1 | B.1.177.63 | 0.002703 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.177.87 | 0.000728 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.236 | 0.002053 |
| ORF1ab/nsp5A-B | 102 | K102X | Aag | Tag | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp5A-B | 102 | K102M | aAg | aTg | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.395 | 0.007042 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.400 | 0.000429 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.473 | 0.019231 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | B.1.560 | 0.00463 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp5A-B | 102 | K102del1 | aAG | aG- | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp5A-B | 102 | K102Y | AaG | TaC | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp5A-B | 102 | K102C | AAG | TGT | 1 | 1 | C.16 | 0.00106 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp5A-B | 102 | K102R | aAg | aGg | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | N.4 | 0.004255 |
| ORF1ab/nsp5A-B | 102 | K102del2 | aAG | a-- | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp5A-B | 102 | K102S | AAg | TCg | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | P.2 | 0.000187 |
| ORF1ab/nsp5A-B | 102 | K102del | AAG | --- | 1 | 1 | Q.2 | 0.000613 |
| ORF1ab/nsp5A-B | 102 | K102K | aaG | aaA | 1 | 1 | Q.8 | 0.000165 |
| ORF1ab/nsp5A-B | 102 | K102N | aaG | aaT | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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