CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = R186R

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4186R186RR2949RsyncgCcgT454044600.9823799110-9112
ORF1ab/nsp4186R186RR2949RsyncgCcgA4540740.01629969110-9112
ORF1ab/nsp4186R186RR2949RsyncgCcgG454060.001321599110-9112

Details of the mutation R186R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4186R186RcgCcgT44604540All0.000853
ORF1ab/nsp4186R186RcgCcgA744540All0.000014
ORF1ab/nsp4186R186RcgCcgG64540All0.000001
ORF1ab/nsp4186R186RcgCcgT26432643AY.40.004114
ORF1ab/nsp4186R186RcgCcgT265282B.1.1.70.000237
ORF1ab/nsp4186R186RcgCcgA17282B.1.1.70.000015
ORF1ab/nsp4186R186RcgCcgT179179P.1.140.008556
ORF1ab/nsp4186R186RcgCcgT174174AY.9.10.014568
ORF1ab/nsp4186R186RcgCcgT168172AY.250.00101
ORF1ab/nsp4186R186RcgCcgA4172AY.250.000024
ORF1ab/nsp4186R186RcgCcgT145146AY.1030.0009
ORF1ab/nsp4186R186RcgCcgA1146AY.1030.000006
ORF1ab/nsp4186R186RcgCcgT106108AY.440.000645
ORF1ab/nsp4186R186RcgCcgA2108AY.440.000012
ORF1ab/nsp4186R186RcgCcgT7376B.1.20.000643
ORF1ab/nsp4186R186RcgCcgA376B.1.20.000026
ORF1ab/nsp4186R186RcgCcgT7172B.1.617.20.000267
ORF1ab/nsp4186R186RcgCcgA172B.1.617.20.000004
ORF1ab/nsp4186R186RcgCcgT6262AY.840.027122
ORF1ab/nsp4186R186RcgCcgT5151B.1.258.240.548387
ORF1ab/nsp4186R186RcgCcgT2536AY.430.000111
ORF1ab/nsp4186R186RcgCcgA1136AY.430.000049
ORF1ab/nsp4186R186RcgCcgT3636P.10.000567
ORF1ab/nsp4186R186RcgCcgT3233B.1.3510.000951
ORF1ab/nsp4186R186RcgCcgA133B.1.3510.00003
ORF1ab/nsp4186R186RcgCcgT2828AY.390.000692
ORF1ab/nsp4186R186RcgCcgT2626B.1.1.5190.001032
ORF1ab/nsp4186R186RcgCcgT2424AY.1200.000892
ORF1ab/nsp4186R186RcgCcgT2224B.1.10.000399
ORF1ab/nsp4186R186RcgCcgG124B.1.10.000018
ORF1ab/nsp4186R186RcgCcgA124B.1.10.000018
ORF1ab/nsp4186R186RcgCcgT1822B.10.000165
ORF1ab/nsp4186R186RcgCcgA322B.10.000027
ORF1ab/nsp4186R186RcgCcgG122B.10.000009
ORF1ab/nsp4186R186RcgCcgT1919B.1.5250.00215
ORF1ab/nsp4186R186RcgCcgT1818B.1.1.4320.022785
ORF1ab/nsp4186R186RcgCcgT1718C.370.001973
ORF1ab/nsp4186R186RcgCcgA118C.370.000116
ORF1ab/nsp4186R186RcgCcgT1616AY.30.000159
ORF1ab/nsp4186R186RcgCcgT1111AY.1110.002015
ORF1ab/nsp4186R186RcgCcgA911AY.1190.000318
ORF1ab/nsp4186R186RcgCcgT211AY.1190.000071
ORF1ab/nsp4186R186RcgCcgT1111B.1.1.3170.004529
ORF1ab/nsp4186R186RcgCcgT1111Q.10.00139
ORF1ab/nsp4186R186RcgCcgT99AY.740.001041
ORF1ab/nsp4186R186RcgCcgT99B.1.177.820.004296
ORF1ab/nsp4186R186RcgCcgT88AY.1020.000212
ORF1ab/nsp4186R186RcgCcgT88B.1.1.1350.037559
ORF1ab/nsp4186R186RcgCcgT88B.1.1.4860.012618
ORF1ab/nsp4186R186RcgCcgT77AY.200.000272
ORF1ab/nsp4186R186RcgCcgA77AY.340.000679
ORF1ab/nsp4186R186RcgCcgT77AY.4.50.000752
ORF1ab/nsp4186R186RcgCcgT66AY.480.002791
ORF1ab/nsp4186R186RcgCcgT35AY.290.000047
ORF1ab/nsp4186R186RcgCcgA25AY.290.000032
ORF1ab/nsp4186R186RcgCcgT55B.1.1.2140.000277
ORF1ab/nsp4186R186RcgCcgT55B.1.5260.000118
ORF1ab/nsp4186R186RcgCcgG340.166667
ORF1ab/nsp4186R186RcgCcgA140.055556
ORF1ab/nsp4186R186RcgCcgT34AY.1000.000138
ORF1ab/nsp4186R186RcgCcgA14AY.1000.000046
ORF1ab/nsp4186R186RcgCcgT44AY.39.10.000158
ORF1ab/nsp4186R186RcgCcgT44B.1.1770.000053
ORF1ab/nsp4186R186RcgCcgT44B.1.2580.000266
ORF1ab/nsp4186R186RcgCcgT44B.1.6280.001409
ORF1ab/nsp4186R186RcgCcgA23AY.1170.000169
ORF1ab/nsp4186R186RcgCcgT13AY.1170.000085
ORF1ab/nsp4186R186RcgCcgT33AY.1180.000188
ORF1ab/nsp4186R186RcgCcgT33AY.29.10.000662
ORF1ab/nsp4186R186RcgCcgT33AY.330.0002
ORF1ab/nsp4186R186RcgCcgT33AY.5.30.001012
ORF1ab/nsp4186R186RcgCcgT33AY.60.000123
ORF1ab/nsp4186R186RcgCcgT33B.1.1.1330.025424
ORF1ab/nsp4186R186RcgCcgT33B.1.1.2840.000322
ORF1ab/nsp4186R186RcgCcgT33B.1.1.3180.000905
ORF1ab/nsp4186R186RcgCcgT33B.1.36.290.001552
ORF1ab/nsp4186R186RcgCcgT33B.1.4270.000151
ORF1ab/nsp4186R186RcgCcgT33B.1.5950.000783
ORF1ab/nsp4186R186RcgCcgT33Q.60.019868
ORF1ab/nsp4186R186RcgCcgT22AY.370.000632
ORF1ab/nsp4186R186RcgCcgT22AY.39.20.003082
ORF1ab/nsp4186R186RcgCcgT22AY.4.20.000043
ORF1ab/nsp4186R186RcgCcgT22AY.420.00008
ORF1ab/nsp4186R186RcgCcgT22AY.460.000208
ORF1ab/nsp4186R186RcgCcgT22AY.470.000062
ORF1ab/nsp4186R186RcgCcgT22AY.50.000041
ORF1ab/nsp4186R186RcgCcgA12AY.750.000056
ORF1ab/nsp4186R186RcgCcgT12AY.750.000056
ORF1ab/nsp4186R186RcgCcgT22AY.780.003082
ORF1ab/nsp4186R186RcgCcgT22AY.920.000575
ORF1ab/nsp4186R186RcgCcgT22AY.980.000158
ORF1ab/nsp4186R186RcgCcgT22B.1.1.10.000653
ORF1ab/nsp4186R186RcgCcgT22B.1.177.810.000379
ORF1ab/nsp4186R186RcgCcgT22B.1.2340.000264
ORF1ab/nsp4186R186RcgCcgT22B.1.438.10.000215
ORF1ab/nsp4186R186RcgCcgT12B.1.4990.00105
ORF1ab/nsp4186R186RcgCcgA12B.1.4990.00105
ORF1ab/nsp4186R186RcgCcgT22B.1.5960.000174
ORF1ab/nsp4186R186RcgCcgT22B.1.80.003945
ORF1ab/nsp4186R186RcgCcgT22D.20.00015
ORF1ab/nsp4186R186RcgCcgT11AD.20.000219
ORF1ab/nsp4186R186RcgCcgT11AY.10.000396
ORF1ab/nsp4186R186RcgCcgT11AY.1140.000231
ORF1ab/nsp4186R186RcgCcgA11AY.1160.000287
ORF1ab/nsp4186R186RcgCcgT11AY.160.00038
ORF1ab/nsp4186R186RcgCcgT11AY.260.000028
ORF1ab/nsp4186R186RcgCcgT11AY.3.10.000085
ORF1ab/nsp4186R186RcgCcgT11AY.34.10.00051
ORF1ab/nsp4186R186RcgCcgT11AY.450.000122
ORF1ab/nsp4186R186RcgCcgT11AY.46.30.000934
ORF1ab/nsp4186R186RcgCcgT11AY.520.000814
ORF1ab/nsp4186R186RcgCcgT11AY.540.000095
ORF1ab/nsp4186R186RcgCcgT11AY.590.00053
ORF1ab/nsp4186R186RcgCcgT11AY.610.000105
ORF1ab/nsp4186R186RcgCcgT11AY.680.000274
ORF1ab/nsp4186R186RcgCcgT11AY.880.000884
ORF1ab/nsp4186R186RcgCcgA11AY.98.10.000048
ORF1ab/nsp4186R186RcgCcgT11B0.000128
ORF1ab/nsp4186R186RcgCcgT11B.1.1.1130.006993
ORF1ab/nsp4186R186RcgCcgT11B.1.1.1980.001468
ORF1ab/nsp4186R186RcgCcgT11B.1.1.2220.000204
ORF1ab/nsp4186R186RcgCcgT11B.1.1.3060.000438
ORF1ab/nsp4186R186RcgCcgT11B.1.1.370.000193
ORF1ab/nsp4186R186RcgCcgT11B.1.1.4340.000349
ORF1ab/nsp4186R186RcgCcgT11B.1.1.540.003021
ORF1ab/nsp4186R186RcgCcgT11B.1.1390.000733
ORF1ab/nsp4186R186RcgCcgT11B.1.160.320.004292
ORF1ab/nsp4186R186RcgCcgT11B.1.1640.014925
ORF1ab/nsp4186R186RcgCcgT11B.1.2210.000071
ORF1ab/nsp4186R186RcgCcgT11B.1.2370.004975
ORF1ab/nsp4186R186RcgCcgT11B.1.2390.001221
ORF1ab/nsp4186R186RcgCcgT11B.1.2790.000514
ORF1ab/nsp4186R186RcgCcgA11B.1.351.50.0006
ORF1ab/nsp4186R186RcgCcgT11B.1.36.70.004
ORF1ab/nsp4186R186RcgCcgT11B.1.3670.000792
ORF1ab/nsp4186R186RcgCcgG11B.1.4290.000024
ORF1ab/nsp4186R186RcgCcgT11B.1.4700.001404
ORF1ab/nsp4186R186RcgCcgT11B.1.617.10.000129
ORF1ab/nsp4186R186RcgCcgT11B.1.6210.000089
ORF1ab/nsp4186R186RcgCcgA11B.1.930.000934
ORF1ab/nsp4186R186RcgCcgT11B.60.00091
ORF1ab/nsp4186R186RcgCcgT11L.10.001905
ORF1ab/nsp4186R186RcgCcgT11P.1.120.000484
ORF1ab/nsp4186R186RcgCcgT11P.1.150.000232
ORF1ab/nsp4186R186RcgCcgT11P.1.70.000319
ORF1ab/nsp4186R186RcgCcgA11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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