CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = R186C

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4186R186CR2949CnonsynCgcTgc46246219110-9112

Details of the mutation R186C within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4186R186CCgcTgc462462All0.000088
ORF1ab/nsp4186R186CCgcTgc9999AY.40.000154
ORF1ab/nsp4186R186CCgcTgc5454B.1.1.70.000048
ORF1ab/nsp4186R186CCgcTgc3838B.1.617.20.000143
ORF1ab/nsp4186R186CCgcTgc2525AY.430.000111
ORF1ab/nsp4186R186CCgcTgc2222AY.1030.000137
ORF1ab/nsp4186R186CCgcTgc1919AY.440.000116
ORF1ab/nsp4186R186CCgcTgc1515D.20.001126
ORF1ab/nsp4186R186CCgcTgc1111AY.30.000109
ORF1ab/nsp4186R186CCgcTgc1010B.1.20.000088
ORF1ab/nsp4186R186CCgcTgc99AY.290.000142
ORF1ab/nsp4186R186CCgcTgc99B.10.000082
ORF1ab/nsp4186R186CCgcTgc88AY.50.000165
ORF1ab/nsp4186R186CCgcTgc77AY.1020.000186
ORF1ab/nsp4186R186CCgcTgc77AY.250.000042
ORF1ab/nsp4186R186CCgcTgc66AY.470.000187
ORF1ab/nsp4186R186CCgcTgc66B.1.1770.000079
ORF1ab/nsp4186R186CCgcTgc55AY.390.000124
ORF1ab/nsp4186R186CCgcTgc44AY.360.000593
ORF1ab/nsp4186R186CCgcTgc44B.1.10.000073
ORF1ab/nsp4186R186CCgcTgc44B.1.1.5190.000159
ORF1ab/nsp4186R186CCgcTgc33AY.300.001187
ORF1ab/nsp4186R186CCgcTgc33AY.9.10.000251
ORF1ab/nsp4186R186CCgcTgc33B.1.1.2430.012245
ORF1ab/nsp4186R186CCgcTgc33B.1.4290.000071
ORF1ab/nsp4186R186CCgcTgc220.111111
ORF1ab/nsp4186R186CCgcTgc22AY.1180.000125
ORF1ab/nsp4186R186CCgcTgc22AY.1190.000071
ORF1ab/nsp4186R186CCgcTgc22AY.1210.000271
ORF1ab/nsp4186R186CCgcTgc22AY.230.000139
ORF1ab/nsp4186R186CCgcTgc22AY.23.10.000835
ORF1ab/nsp4186R186CCgcTgc22AY.29.10.000441
ORF1ab/nsp4186R186CCgcTgc22AY.330.000134
ORF1ab/nsp4186R186CCgcTgc22AY.39.10.000079
ORF1ab/nsp4186R186CCgcTgc22AY.420.00008
ORF1ab/nsp4186R186CCgcTgc22AY.460.000208
ORF1ab/nsp4186R186CCgcTgc22AY.46.60.000144
ORF1ab/nsp4186R186CCgcTgc22AY.60.000082
ORF1ab/nsp4186R186CCgcTgc22AY.980.000158
ORF1ab/nsp4186R186CCgcTgc22B.1.1.2140.000111
ORF1ab/nsp4186R186CCgcTgc22B.1.177.810.000379
ORF1ab/nsp4186R186CCgcTgc22B.1.2210.000142
ORF1ab/nsp4186R186CCgcTgc22B.1.3510.000059
ORF1ab/nsp4186R186CCgcTgc22B.1.36.180.00084
ORF1ab/nsp4186R186CCgcTgc22B.1.6090.000959
ORF1ab/nsp4186R186CCgcTgc22R.10.00018
ORF1ab/nsp4186R186CCgcTgc11A.270.001656
ORF1ab/nsp4186R186CCgcTgc11AE.80.000489
ORF1ab/nsp4186R186CCgcTgc11AT.10.005128
ORF1ab/nsp4186R186CCgcTgc11AY.1000.000046
ORF1ab/nsp4186R186CCgcTgc11AY.1100.000113
ORF1ab/nsp4186R186CCgcTgc11AY.1200.000037
ORF1ab/nsp4186R186CCgcTgc11AY.120.10.000321
ORF1ab/nsp4186R186CCgcTgc11AY.200.000039
ORF1ab/nsp4186R186CCgcTgc11AY.240.000431
ORF1ab/nsp4186R186CCgcTgc11AY.340.000097
ORF1ab/nsp4186R186CCgcTgc11AY.350.000233
ORF1ab/nsp4186R186CCgcTgc11AY.4.50.000107
ORF1ab/nsp4186R186CCgcTgc11AY.450.000122
ORF1ab/nsp4186R186CCgcTgc11AY.7.10.000113
ORF1ab/nsp4186R186CCgcTgc11AY.860.00083
ORF1ab/nsp4186R186CCgcTgc11AY.930.000273
ORF1ab/nsp4186R186CCgcTgc11AY.940.000443
ORF1ab/nsp4186R186CCgcTgc11AY.950.000761
ORF1ab/nsp4186R186CCgcTgc11AY.960.002075
ORF1ab/nsp4186R186CCgcTgc11AY.98.10.000048
ORF1ab/nsp4186R186CCgcTgc11B0.000128
ORF1ab/nsp4186R186CCgcTgc11B.1.1.2630.001558
ORF1ab/nsp4186R186CCgcTgc11B.1.1.2890.002083
ORF1ab/nsp4186R186CCgcTgc11B.1.1.390.00051
ORF1ab/nsp4186R186CCgcTgc11B.1.177.100.000878
ORF1ab/nsp4186R186CCgcTgc11B.1.177.330.001645
ORF1ab/nsp4186R186CCgcTgc11B.1.177.40.000211
ORF1ab/nsp4186R186CCgcTgc11B.1.177.570.000281
ORF1ab/nsp4186R186CCgcTgc11B.1.177.820.000477
ORF1ab/nsp4186R186CCgcTgc11B.1.2340.000132
ORF1ab/nsp4186R186CCgcTgc11B.1.2360.002053
ORF1ab/nsp4186R186CCgcTgc11B.1.2410.000812
ORF1ab/nsp4186R186CCgcTgc11B.1.2580.000067
ORF1ab/nsp4186R186CCgcTgc11B.1.3690.000285
ORF1ab/nsp4186R186CCgcTgc11B.1.3990.001934
ORF1ab/nsp4186R186CCgcTgc11B.1.438.10.000107
ORF1ab/nsp4186R186CCgcTgc11B.1.5090.000866
ORF1ab/nsp4186R186CCgcTgc11B.1.5260.000024
ORF1ab/nsp4186R186CCgcTgc11B.1.5570.05
ORF1ab/nsp4186R186CCgcTgc11B.1.5640.000426
ORF1ab/nsp4186R186CCgcTgc11B.1.6120.002653
ORF1ab/nsp4186R186CCgcTgc11B.1.617.10.000129
ORF1ab/nsp4186R186CCgcTgc11B.1.6210.000089
ORF1ab/nsp4186R186CCgcTgc11B.230.002924
ORF1ab/nsp4186R186CCgcTgc11B.40.002208
ORF1ab/nsp4186R186CCgcTgc11P.1.100.000269

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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