CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = K35L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp4	35	K35L	K2798L	nonsyn	AAa	TTa	151	148	0.980132	8657-8659
ORF1ab/nsp4	35	K35L	K2798L	nonsyn	AAa	CTa	151	2	0.013245	8657-8659
ORF1ab/nsp4	35	K35L	K2798L	nonsyn	AAA	CTT	151	1	0.00662252	8657-8659

Details of the mutation K35L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp4	35	K35L	AAa	TTa	148	151	All	0.000028
ORF1ab/nsp4	35	K35L	AAa	CTa	2	151	All	0
ORF1ab/nsp4	35	K35L	AAA	CTT	1	151	All	0
ORF1ab/nsp4	35	K35L	AAa	TTa	136	138	B.1.1.7	0.000122
ORF1ab/nsp4	35	K35L	AAA	CTT	1	138	B.1.1.7	0.000001
ORF1ab/nsp4	35	K35L	AAa	CTa	1	138	B.1.1.7	0.000001
ORF1ab/nsp4	35	K35L	AAa	TTa	6	6	P.1	0.000095
ORF1ab/nsp4	35	K35L	AAa	TTa	1	2	B.1	0.000009
ORF1ab/nsp4	35	K35L	AAa	CTa	1	2	B.1	0.000009
ORF1ab/nsp4	35	K35L	AAa	TTa	2	2	B.1.1	0.000036
ORF1ab/nsp4	35	K35L	AAa	TTa	1	1	AY.25	0.000006
ORF1ab/nsp4	35	K35L	AAa	TTa	1	1	B.1.576	0.000907
ORF1ab/nsp4	35	K35L	AAa	TTa	1	1	B.1.617.2	0.000004

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.