CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = H389Q

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4389H389QH3152QnonsyncaTcaG110620.5636369719-9721
ORF1ab/nsp4389H389QH3152QnonsyncaTcaA110480.4363649719-9721

Details of the mutation H389Q within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4389H389QcaTcaG62110All0.000012
ORF1ab/nsp4389H389QcaTcaA48110All0.000009
ORF1ab/nsp4389H389QcaTcaA3537AY.1030.000217
ORF1ab/nsp4389H389QcaTcaG237AY.1030.000012
ORF1ab/nsp4389H389QcaTcaG3131B.1.5170.013237
ORF1ab/nsp4389H389QcaTcaA66AY.4.20.00013
ORF1ab/nsp4389H389QcaTcaG45AY.40.000006
ORF1ab/nsp4389H389QcaTcaA15AY.40.000002
ORF1ab/nsp4389H389QcaTcaG34B.1.10.000054
ORF1ab/nsp4389H389QcaTcaA14B.1.10.000018
ORF1ab/nsp4389H389QcaTcaG44B.1.177.810.000757
ORF1ab/nsp4389H389QcaTcaA22AY.1140.000462
ORF1ab/nsp4389H389QcaTcaG22AY.1210.000271
ORF1ab/nsp4389H389QcaTcaG22AY.250.000012
ORF1ab/nsp4389H389QcaTcaG22AY.390.000049
ORF1ab/nsp4389H389QcaTcaG22AY.440.000012
ORF1ab/nsp4389H389QcaTcaG22B.1.1770.000026
ORF1ab/nsp4389H389QcaTcaG22B.1.617.20.000008
ORF1ab/nsp4389H389QcaTcaA110.055556
ORF1ab/nsp4389H389QcaTcaG11AU.10.001266
ORF1ab/nsp4389H389QcaTcaG11AY.200.000039
ORF1ab/nsp4389H389QcaTcaG11AY.580.000907
ORF1ab/nsp4389H389QcaTcaA11B.10.000009
ORF1ab/nsp4389H389QcaTcaG11B.1.1.3690.000446
ORF1ab/nsp4389H389QcaTcaG11B.1.1.3770.001381
ORF1ab/nsp4389H389QcaTcaG11B.1.1600.000031
ORF1ab/nsp4389H389QcaTcaA11B.1.5760.000907

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.