CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = D459N

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4459D459ND3222NnonsynGatAat371037000.9973059929-9931
ORF1ab/nsp4459D459ND3222NnonsynGaTAaC3710100.002695429929-9931

Details of the mutation D459N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4459D459NGatAat37003710All0.000708
ORF1ab/nsp4459D459NGaTAaC103710All0.000002
ORF1ab/nsp4459D459NGatAat17461747C.36.30.990357
ORF1ab/nsp4459D459NGaTAaC11747C.36.30.000567
ORF1ab/nsp4459D459NGatAat522522C.360.47541
ORF1ab/nsp4459D459NGatAat503507B.1.1.70.00045
ORF1ab/nsp4459D459NGaTAaC4507B.1.1.70.000004
ORF1ab/nsp4459D459NGatAat328328C.36.3.10.891304
ORF1ab/nsp4459D459NGatAat132132B.10.001209
ORF1ab/nsp4459D459NGatAat6969B.1.243.21
ORF1ab/nsp4459D459NGatAat4646B.1.5090.039827
ORF1ab/nsp4459D459NGatAat3737AY.40.000058
ORF1ab/nsp4459D459NGatAat3333B.1.3460.04325
ORF1ab/nsp4459D459NGatAat3030B.1.10.000544
ORF1ab/nsp4459D459NGatAat2424B.1.1820.173913
ORF1ab/nsp4459D459NGatAat2020B.1.1770.000263
ORF1ab/nsp4459D459NGatAat1616AY.60.000658
ORF1ab/nsp4459D459NGatAat1414B.1.617.20.000053
ORF1ab/nsp4459D459NGatAat1010AY.1000.00046
ORF1ab/nsp4459D459NGatAat99AY.430.00004
ORF1ab/nsp4459D459NGatAat88AY.200.000311
ORF1ab/nsp4459D459NGatAat88B.1.1.2940.010127
ORF1ab/nsp4459D459NGatAat88P.1.70.002554
ORF1ab/nsp4459D459NGatAat77P.1.140.000335
ORF1ab/nsp4459D459NGatAat66AY.1210.000812
ORF1ab/nsp4459D459NGatAat66C.170.333333
ORF1ab/nsp4459D459NGatAat55B.1.230.030303
ORF1ab/nsp4459D459NGatAat55C.350.00387
ORF1ab/nsp4459D459NGatAat55C.390.09434
ORF1ab/nsp4459D459NGatAat55P.50.068493
ORF1ab/nsp4459D459NGatAat44AY.260.000113
ORF1ab/nsp4459D459NGatAat44AY.3.10.000341
ORF1ab/nsp4459D459NGatAat44B.1.6370.000292
ORF1ab/nsp4459D459NGatAat33AY.1030.000019
ORF1ab/nsp4459D459NGatAat33AY.440.000018
ORF1ab/nsp4459D459NGatAat33B.1.1.10.00098
ORF1ab/nsp4459D459NGatAat33B.1.1.280.000934
ORF1ab/nsp4459D459NGatAat33B.1.2390.003663
ORF1ab/nsp4459D459NGatAat33B.1.3510.000089
ORF1ab/nsp4459D459NGatAat33B.60.00273
ORF1ab/nsp4459D459NGatAat33C.160.003181
ORF1ab/nsp4459D459NGatAat23P.10.000032
ORF1ab/nsp4459D459NGaTAaC13P.10.000016
ORF1ab/nsp4459D459NGatAat22AY.1020.000053
ORF1ab/nsp4459D459NGatAat22AY.140.000176
ORF1ab/nsp4459D459NGatAat22AY.250.000012
ORF1ab/nsp4459D459NGatAat22AY.380.000999
ORF1ab/nsp4459D459NGatAat22AY.530.000575
ORF1ab/nsp4459D459NGatAat22B.1.1.2410.004141
ORF1ab/nsp4459D459NGatAat22B.1.1.3720.001377
ORF1ab/nsp4459D459NGatAat22B.1.1.4580.083333
ORF1ab/nsp4459D459NGatAat12B.1.20.000009
ORF1ab/nsp4459D459NGaTAaC12B.1.20.000009
ORF1ab/nsp4459D459NGatAat22B.1.3240.00321
ORF1ab/nsp4459D459NGatAat22B.1.3750.001639
ORF1ab/nsp4459D459NGatAat22B.1.4480.005249
ORF1ab/nsp4459D459NGatAat22B.1.6230.001073
ORF1ab/nsp4459D459NGatAat22B.1.810.042553
ORF1ab/nsp4459D459NGatAat22Q.80.00033
ORF1ab/nsp4459D459NGatAat11AY.1010.00049
ORF1ab/nsp4459D459NGatAat11AY.1070.000466
ORF1ab/nsp4459D459NGatAat11AY.1170.000085
ORF1ab/nsp4459D459NGatAat11AY.120.10.000321
ORF1ab/nsp4459D459NGatAat11AY.290.000016
ORF1ab/nsp4459D459NGaTAaC11AY.30.00001
ORF1ab/nsp4459D459NGatAat11AY.370.000316
ORF1ab/nsp4459D459NGatAat11AY.390.000025
ORF1ab/nsp4459D459NGatAat11AY.4.20.000022
ORF1ab/nsp4459D459NGatAat11AY.740.000116
ORF1ab/nsp4459D459NGaTAaC11AY.750.000056
ORF1ab/nsp4459D459NGatAat11B0.000128
ORF1ab/nsp4459D459NGatAat11B.1.1.1820.090909
ORF1ab/nsp4459D459NGatAat11B.1.1.2140.000055
ORF1ab/nsp4459D459NGatAat11B.1.1.2200.001859
ORF1ab/nsp4459D459NGaTAaC11B.1.1.3480.000796
ORF1ab/nsp4459D459NGatAat11B.1.1.4020.011111
ORF1ab/nsp4459D459NGatAat11B.1.1.5190.00004
ORF1ab/nsp4459D459NGatAat11B.1.1.5230.001563
ORF1ab/nsp4459D459NGatAat11B.1.1080.005814
ORF1ab/nsp4459D459NGatAat11B.1.1600.000031
ORF1ab/nsp4459D459NGatAat11B.1.177.30.007634
ORF1ab/nsp4459D459NGatAat11B.1.177.440.000519
ORF1ab/nsp4459D459NGatAat11B.1.177.530.002392
ORF1ab/nsp4459D459NGatAat11B.1.2210.000071
ORF1ab/nsp4459D459NGatAat11B.1.2430.00007
ORF1ab/nsp4459D459NGatAat11B.1.3560.001727
ORF1ab/nsp4459D459NGatAat11B.1.3690.000285
ORF1ab/nsp4459D459NGatAat11B.1.3990.001934
ORF1ab/nsp4459D459NGatAat11B.1.5950.000261
ORF1ab/nsp4459D459NGatAat11B.1.6050.005952
ORF1ab/nsp4459D459NGatAat11B.1.6210.000089
ORF1ab/nsp4459D459NGatAat11B.1.621.10.000506
ORF1ab/nsp4459D459NGatAat11P.1.120.000484

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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