CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = D217X

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp4	217	D217X	D2980X	nonsyn	GaT	TaA	2	1	0.5	9203-9205
ORF1ab/nsp4	217	D217X	D2980X	nonsyn	GAT	TGA	2	1	0.5	9203-9205

Details of the mutation D217X within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp4	217	D217X	GaT	TaA	1	2		0.055556
ORF1ab/nsp4	217	D217X	GAT	TGA	1	2		0.055556
ORF1ab/nsp4	217	D217X	GaT	TaA	1	2	All	0
ORF1ab/nsp4	217	D217X	GAT	TGA	1	2	All	0

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.