CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = D217E

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4217D217ED2980EnonsyngaTgaG54430.7962969203-9205
ORF1ab/nsp4217D217ED2980EnonsyngaTgaA54110.2037049203-9205

Details of the mutation D217E within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4217D217EgaTgaG4354All0.000008
ORF1ab/nsp4217D217EgaTgaA1154All0.000002
ORF1ab/nsp4217D217EgaTgaG1111B.1.10.0002
ORF1ab/nsp4217D217EgaTgaG56AY.430.000022
ORF1ab/nsp4217D217EgaTgaA16AY.430.000004
ORF1ab/nsp4217D217EgaTgaG46B.1.1.70.000004
ORF1ab/nsp4217D217EgaTgaA26B.1.1.70.000002
ORF1ab/nsp4217D217EgaTgaG45B.10.000037
ORF1ab/nsp4217D217EgaTgaA15B.10.000009
ORF1ab/nsp4217D217EgaTgaG44AY.250.000024
ORF1ab/nsp4217D217EgaTgaA23B.1.617.20.000008
ORF1ab/nsp4217D217EgaTgaG13B.1.617.20.000004
ORF1ab/nsp4217D217EgaTgaG22AY.1030.000012
ORF1ab/nsp4217D217EgaTgaG22AY.390.000049
ORF1ab/nsp4217D217EgaTgaG22AY.4.20.000043
ORF1ab/nsp4217D217EgaTgaA22B.1.5820.000981
ORF1ab/nsp4217D217EgaTgaA110.055556
ORF1ab/nsp4217D217EgaTgaG11AY.40.000002
ORF1ab/nsp4217D217EgaTgaA11AY.440.000006
ORF1ab/nsp4217D217EgaTgaG11AY.530.000288
ORF1ab/nsp4217D217EgaTgaG11AY.690.000187
ORF1ab/nsp4217D217EgaTgaG11B.1.1.2630.001558
ORF1ab/nsp4217D217EgaTgaG11B.1.1.5190.00004
ORF1ab/nsp4217D217EgaTgaA11B.1.3110.000275
ORF1ab/nsp4217D217EgaTgaG11B.1.4620.007246
ORF1ab/nsp4217D217EgaTgaG11P.10.000016
ORF1ab/nsp4217D217EgaTgaG11Q.40.000455

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.