CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = A457A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4457A457AA3220AsyngcAgcG7955370.6754729923-9925
ORF1ab/nsp4457A457AA3220AsyngcAgcT7952160.2716989923-9925
ORF1ab/nsp4457A457AA3220AsyngcAgcC795420.05283029923-9925

Details of the mutation A457A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4457A457AgcAgcG537795All0.000103
ORF1ab/nsp4457A457AgcAgcT216795All0.000041
ORF1ab/nsp4457A457AgcAgcC42795All0.000008
ORF1ab/nsp4457A457AgcAgcG382382B.1.36.380.627258
ORF1ab/nsp4457A457AgcAgcT7979B.1.177.720.267797
ORF1ab/nsp4457A457AgcAgcG2455AY.40.000037
ORF1ab/nsp4457A457AgcAgcC2455AY.40.000037
ORF1ab/nsp4457A457AgcAgcT755AY.40.000011
ORF1ab/nsp4457A457AgcAgcG2237B.1.1.70.00002
ORF1ab/nsp4457A457AgcAgcT1437B.1.1.70.000013
ORF1ab/nsp4457A457AgcAgcC137B.1.1.70.000001
ORF1ab/nsp4457A457AgcAgcG2736AY.1030.000168
ORF1ab/nsp4457A457AgcAgcT736AY.1030.000043
ORF1ab/nsp4457A457AgcAgcC236AY.1030.000012
ORF1ab/nsp4457A457AgcAgcG2729B.1.20.000238
ORF1ab/nsp4457A457AgcAgcT229B.1.20.000018
ORF1ab/nsp4457A457AgcAgcT2222AY.140.001936
ORF1ab/nsp4457A457AgcAgcT1113P.10.000173
ORF1ab/nsp4457A457AgcAgcG213P.10.000032
ORF1ab/nsp4457A457AgcAgcG1112B.1.2210.000781
ORF1ab/nsp4457A457AgcAgcT112B.1.2210.000071
ORF1ab/nsp4457A457AgcAgcT1111AY.230.000767
ORF1ab/nsp4457A457AgcAgcG99AY.260.000255
ORF1ab/nsp4457A457AgcAgcC99B.1.1.630.003472
ORF1ab/nsp4457A457AgcAgcG88B.1.360.001167
ORF1ab/nsp4457A457AgcAgcT24AY.1020.000053
ORF1ab/nsp4457A457AgcAgcG24AY.1020.000053
ORF1ab/nsp4457A457AgcAgcT44AY.1160.001147
ORF1ab/nsp4457A457AgcAgcT44AY.750.000224
ORF1ab/nsp4457A457AgcAgcT24B.1.617.20.000008
ORF1ab/nsp4457A457AgcAgcC14B.1.617.20.000004
ORF1ab/nsp4457A457AgcAgcG14B.1.617.20.000004
ORF1ab/nsp4457A457AgcAgcG23AY.250.000012
ORF1ab/nsp4457A457AgcAgcT13AY.250.000006
ORF1ab/nsp4457A457AgcAgcT23AY.430.000009
ORF1ab/nsp4457A457AgcAgcC13AY.430.000004
ORF1ab/nsp4457A457AgcAgcT33AY.440.000018
ORF1ab/nsp4457A457AgcAgcT23B.1.1770.000026
ORF1ab/nsp4457A457AgcAgcG13B.1.1770.000013
ORF1ab/nsp4457A457AgcAgcT33B.1.3510.000089
ORF1ab/nsp4457A457AgcAgcG23B.1.5260.000047
ORF1ab/nsp4457A457AgcAgcT13B.1.5260.000024
ORF1ab/nsp4457A457AgcAgcT23P.1.140.000096
ORF1ab/nsp4457A457AgcAgcG13P.1.140.000048
ORF1ab/nsp4457A457AgcAgcT22AD.20.000438
ORF1ab/nsp4457A457AgcAgcT22AY.200.000078
ORF1ab/nsp4457A457AgcAgcT12AY.46.60.000072
ORF1ab/nsp4457A457AgcAgcG12AY.46.60.000072
ORF1ab/nsp4457A457AgcAgcT12AY.480.000465
ORF1ab/nsp4457A457AgcAgcG12AY.480.000465
ORF1ab/nsp4457A457AgcAgcT22AY.9.10.000167
ORF1ab/nsp4457A457AgcAgcT12AY.980.000079
ORF1ab/nsp4457A457AgcAgcC12AY.980.000079
ORF1ab/nsp4457A457AgcAgcG12B.10.000009
ORF1ab/nsp4457A457AgcAgcT12B.10.000009
ORF1ab/nsp4457A457AgcAgcG12B.1.10.000018
ORF1ab/nsp4457A457AgcAgcC12B.1.10.000018
ORF1ab/nsp4457A457AgcAgcT22B.1.1.1980.002937
ORF1ab/nsp4457A457AgcAgcT22B.1.1.2220.000408
ORF1ab/nsp4457A457AgcAgcT22B.1.1.2980.001724
ORF1ab/nsp4457A457AgcAgcG12B.1.1.5190.00004
ORF1ab/nsp4457A457AgcAgcT12B.1.1.5190.00004
ORF1ab/nsp4457A457AgcAgcT12B.1.4290.000024
ORF1ab/nsp4457A457AgcAgcC12B.1.4290.000024
ORF1ab/nsp4457A457AgcAgcG22B.1.466.20.000782
ORF1ab/nsp4457A457AgcAgcT11AY.120.000316
ORF1ab/nsp4457A457AgcAgcG11AY.30.00001
ORF1ab/nsp4457A457AgcAgcG11AY.4.20.000022
ORF1ab/nsp4457A457AgcAgcG11AY.420.00004
ORF1ab/nsp4457A457AgcAgcT11AY.50.000021
ORF1ab/nsp4457A457AgcAgcT11AY.580.000907
ORF1ab/nsp4457A457AgcAgcT11AY.590.00053
ORF1ab/nsp4457A457AgcAgcT11AY.75.10.00018
ORF1ab/nsp4457A457AgcAgcT11AY.870.000833
ORF1ab/nsp4457A457AgcAgcT11B.1.1.2140.000055
ORF1ab/nsp4457A457AgcAgcT11B.1.1.280.000311
ORF1ab/nsp4457A457AgcAgcT11B.1.1.3180.000302
ORF1ab/nsp4457A457AgcAgcG11B.1.160.150.00495
ORF1ab/nsp4457A457AgcAgcT11B.1.177.420.000894
ORF1ab/nsp4457A457AgcAgcT11B.1.177.460.000918
ORF1ab/nsp4457A457AgcAgcG11B.1.177.60.000977
ORF1ab/nsp4457A457AgcAgcG11B.1.177.730.000566
ORF1ab/nsp4457A457AgcAgcT11B.1.1790.003759
ORF1ab/nsp4457A457AgcAgcT11B.1.258.40.003448
ORF1ab/nsp4457A457AgcAgcG11B.1.3850.010638
ORF1ab/nsp4457A457AgcAgcT11B.1.5240.001406
ORF1ab/nsp4457A457AgcAgcG11B.1.5250.000113
ORF1ab/nsp4457A457AgcAgcG11B.1.5500.013699
ORF1ab/nsp4457A457AgcAgcT11B.1.6280.000352
ORF1ab/nsp4457A457AgcAgcT11B.400.000364
ORF1ab/nsp4457A457AgcAgcC11D.20.000075
ORF1ab/nsp4457A457AgcAgcT11P.1.150.000232
ORF1ab/nsp4457A457AgcAgcT11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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