CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : Mut = A446S

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4446A446SA3209SnonsynGctTct44644619890-9892

Details of the mutation A446S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4446A446SGctTct446446All0.000085
ORF1ab/nsp4446A446SGctTct7373B.1.1.531
ORF1ab/nsp4446A446SGctTct5858B.1.617.20.000218
ORF1ab/nsp4446A446SGctTct5454B.1.10.00098
ORF1ab/nsp4446A446SGctTct4646B.1.20.000405
ORF1ab/nsp4446A446SGctTct2828AY.40.000044
ORF1ab/nsp4446A446SGctTct2727B.1.1.70.000024
ORF1ab/nsp4446A446SGctTct2323AY.1030.000143
ORF1ab/nsp4446A446SGctTct2020B.10.000183
ORF1ab/nsp4446A446SGctTct1313AY.430.000058
ORF1ab/nsp4446A446SGctTct1212AY.250.000072
ORF1ab/nsp4446A446SGctTct1111AY.440.000067
ORF1ab/nsp4446A446SGctTct66B.1.1.520.073171
ORF1ab/nsp4446A446SGctTct66B.1.2410.00487
ORF1ab/nsp4446A446SGctTct55B.1.4270.000252
ORF1ab/nsp4446A446SGctTct44P.10.000063
ORF1ab/nsp4446A446SGctTct33AY.290.000047
ORF1ab/nsp4446A446SGctTct33AY.30.00003
ORF1ab/nsp4446A446SGctTct33AY.330.0002
ORF1ab/nsp4446A446SGctTct33AY.390.000074
ORF1ab/nsp4446A446SGctTct33B.1.1.3980.009677
ORF1ab/nsp4446A446SGctTct33D.20.000225
ORF1ab/nsp4446A446SGctTct22A0.000774
ORF1ab/nsp4446A446SGctTct22AY.1020.000053
ORF1ab/nsp4446A446SGctTct22AY.1100.000225
ORF1ab/nsp4446A446SGctTct22AY.1190.000071
ORF1ab/nsp4446A446SGctTct22B.1.1.3060.000877
ORF1ab/nsp4446A446SGctTct22B.1.1.390.001019
ORF1ab/nsp4446A446SGctTct22B.1.1.5190.000079
ORF1ab/nsp4446A446SGctTct22B.1.1110.00235
ORF1ab/nsp4446A446SGctTct22B.1.4290.000047
ORF1ab/nsp4446A446SGctTct22B.1.5600.009259
ORF1ab/nsp4446A446SGctTct22P.20.000373
ORF1ab/nsp4446A446SGctTct11A.2.50.000499
ORF1ab/nsp4446A446SGctTct11AS.10.009524
ORF1ab/nsp4446A446SGctTct11AY.1050.000643
ORF1ab/nsp4446A446SGctTct11AY.230.00007
ORF1ab/nsp4446A446SGctTct11AY.4.20.000022
ORF1ab/nsp4446A446SGctTct11AY.420.00004
ORF1ab/nsp4446A446SGctTct11AY.450.000122
ORF1ab/nsp4446A446SGctTct11AY.980.000079
ORF1ab/nsp4446A446SGctTct11B0.000128
ORF1ab/nsp4446A446SGctTct11B.1.1.1530.001095
ORF1ab/nsp4446A446SGctTct11B.1.1.3770.001381
ORF1ab/nsp4446A446SGctTct11B.1.1.4090.002833
ORF1ab/nsp4446A446SGctTct11B.1.1770.000013
ORF1ab/nsp4446A446SGctTct11B.1.177.40.000211
ORF1ab/nsp4446A446SGctTct11B.1.177.480.003125
ORF1ab/nsp4446A446SGctTct11B.1.177.560.000668
ORF1ab/nsp4446A446SGctTct11B.1.360.000146
ORF1ab/nsp4446A446SGctTct11B.1.4560.003268
ORF1ab/nsp4446A446SGctTct11B.1.780.008547
ORF1ab/nsp4446A446SGctTct11B.400.000364

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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