CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : CodonNum = 457 & Codon = gcC

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp4	457	A457A	A3220A	syn	gcA	gcC	795	42	0.0528302	9923-9925

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp4	457	A457A	gcA	gcC	42	795	All	0.000008
ORF1ab/nsp4	457	A457A	gcA	gcC	24	55	AY.4	0.000037
ORF1ab/nsp4	457	A457A	gcA	gcC	1	37	B.1.1.7	0.000001
ORF1ab/nsp4	457	A457A	gcA	gcC	2	36	AY.103	0.000012
ORF1ab/nsp4	457	A457A	gcA	gcC	9	9	B.1.1.63	0.003472
ORF1ab/nsp4	457	A457A	gcA	gcC	1	4	B.1.617.2	0.000004
ORF1ab/nsp4	457	A457A	gcA	gcC	1	3	AY.43	0.000004
ORF1ab/nsp4	457	A457A	gcA	gcC	1	2	AY.98	0.000079
ORF1ab/nsp4	457	A457A	gcA	gcC	1	2	B.1.1	0.000018
ORF1ab/nsp4	457	A457A	gcA	gcC	1	2	B.1.429	0.000024
ORF1ab/nsp4	457	A457A	gcA	gcC	1	1	D.2	0.000075

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.