CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : CodonNum = 449

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4449N449NN3212NsynaaTaaC1376137619899-9901
ORF1ab/nsp4449N449TN3212TnonsynaAtaCt2662650.9962419899-9901
ORF1ab/nsp4449N449TN3212TnonsynaATaCC26610.00375949899-9901
ORF1ab/nsp4449N449delN3212deldelAAT---11511519899-9901
ORF1ab/nsp4449N449SN3212SnonsynaAtaGt68670.9852949899-9901
ORF1ab/nsp4449N449SN3212SnonsynAAtTCt6810.01470599899-9901
ORF1ab/nsp4449N449KN3212KnonsynaaTaaG27160.5925939899-9901
ORF1ab/nsp4449N449KN3212KnonsynaaTaaA27110.4074079899-9901
ORF1ab/nsp4449N449YN3212YnonsynAatTat101019899-9901
ORF1ab/nsp4449N449IN3212InonsynaAtaTt9919899-9901
ORF1ab/nsp4449N449del1N3212del1delaaTaa-840.59899-9901
ORF1ab/nsp4449N449del1N3212del1delAat-at840.59899-9901
ORF1ab/nsp4449N449DN3212DnonsynAatGat4419899-9901
ORF1ab/nsp4449N449del2N3212del2delaATa--210.59899-9901
ORF1ab/nsp4449N449del2N3212del2delAAt--t210.59899-9901
ORF1ab/nsp4449N449GN3212GnonsynAAtGGt1119899-9901
ORF1ab/nsp4449N449FN3212FnonsynAAtTTt1119899-9901
ORF1ab/nsp4449N449CN3212CnonsynAATTGC1119899-9901

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4449N449NaaTaaC13761376All0.000263
ORF1ab/nsp4449N449NaaTaaC529529AY.430.002344
ORF1ab/nsp4449N449TaAtaCt265266All0.000051
ORF1ab/nsp4449N449TaATaCC1266All0
ORF1ab/nsp4449N449TaAtaCt245245B.1.1.2431
ORF1ab/nsp4449N449NaaTaaC240240AY.440.001461
ORF1ab/nsp4449N449NaaTaaC230230B.1.1.70.000206
ORF1ab/nsp4449N449NaaTaaC126126B.1.617.20.000474
ORF1ab/nsp4449N449delAAT---115115All0.000022
ORF1ab/nsp4449N449SaAtaGt6768All0.000013
ORF1ab/nsp4449N449SAAtTCt168All0
ORF1ab/nsp4449N449SaAtaGt3838AY.1190.001342
ORF1ab/nsp4449N449delAAT---3434B.1.1.70.00003
ORF1ab/nsp4449N449KaaTaaG1627All0.000003
ORF1ab/nsp4449N449KaaTaaA1127All0.000002
ORF1ab/nsp4449N449NaaTaaC2525AY.1060.008372
ORF1ab/nsp4449N449NaaTaaC1818AY.99.20.001659
ORF1ab/nsp4449N449NaaTaaC1515P.10.000236
ORF1ab/nsp4449N449NaaTaaC1414AY.1030.000087
ORF1ab/nsp4449N449NaaTaaC1414AY.40.000022
ORF1ab/nsp4449N449KaaTaaG1414B.1.3150.084848
ORF1ab/nsp4449N449NaaTaaC1414B.1.4160.017766
ORF1ab/nsp4449N449NaaTaaC1111AT.10.05641
ORF1ab/nsp4449N449NaaTaaC1111AY.1090.008136
ORF1ab/nsp4449N449YAatTat1010All0.000002
ORF1ab/nsp4449N449delAAT---1010B.10.000092
ORF1ab/nsp4449N449IaAtaTt99All0.000002
ORF1ab/nsp4449N449del1Aat-at48All0.000001
ORF1ab/nsp4449N449del1aaTaa-48All0.000001
ORF1ab/nsp4449N449NaaTaaC88B.1.10.000145
ORF1ab/nsp4449N449delAAT---77AY.750.000392
ORF1ab/nsp4449N449NaaTaaC77B.1.4290.000165
ORF1ab/nsp4449N449delAAT---77P.10.00011
ORF1ab/nsp4449N449NaaTaaC66AY.1020.000159
ORF1ab/nsp4449N449NaaTaaC66AY.230.000418
ORF1ab/nsp4449N449NaaTaaC66AY.290.000095
ORF1ab/nsp4449N449SaAtaGt55AY.1130.000712
ORF1ab/nsp4449N449NaaTaaC55AY.1190.000177
ORF1ab/nsp4449N449KaaTaaA55AY.4.50.000537
ORF1ab/nsp4449N449NaaTaaC55B.10.000046
ORF1ab/nsp4449N449delAAT---55B.1.10.000091
ORF1ab/nsp4449N449TaAtaCt55B.1.10.000091
ORF1ab/nsp4449N449TaAtaCt55B.1.416.10.007812
ORF1ab/nsp4449N449delAAT---55P.1.120.00242
ORF1ab/nsp4449N449DAatGat44All0.000001
ORF1ab/nsp4449N449NaaTaaC44AY.250.000024
ORF1ab/nsp4449N449SaAtaGt44AY.340.000388
ORF1ab/nsp4449N449NaaTaaC44AY.390.000099
ORF1ab/nsp4449N449delAAT---44AY.4.50.00043
ORF1ab/nsp4449N449NaaTaaC44AY.460.000416
ORF1ab/nsp4449N449NaaTaaC44AY.610.000419
ORF1ab/nsp4449N449NaaTaaC44AY.630.001547
ORF1ab/nsp4449N449delAAT---44B.1.1770.000053
ORF1ab/nsp4449N449NaaTaaC44B.1.3510.000119
ORF1ab/nsp4449N449NaaTaaC44B.1.360.000584
ORF1ab/nsp4449N449NaaTaaC33AY.30.00003
ORF1ab/nsp4449N449delAAT---33AY.390.000074
ORF1ab/nsp4449N449KaaTaaA33AY.40.000005
ORF1ab/nsp4449N449NaaTaaC33AY.60.000123
ORF1ab/nsp4449N449NaaTaaC33B.1.1.2840.000322
ORF1ab/nsp4449N449NaaTaaC33B.1.20.000026
ORF1ab/nsp4449N449NaaTaaC33B.1.2210.000213
ORF1ab/nsp4449N449del1aaTaa-33B.1.5250.000339
ORF1ab/nsp4449N449TaAtaCt33B.1.780.025641
ORF1ab/nsp4449N449del2aATa--12All0
ORF1ab/nsp4449N449del2AAt--t12All0
ORF1ab/nsp4449N449SaAtaGt22AY.1110.000366
ORF1ab/nsp4449N449NaaTaaC22AY.1160.000574
ORF1ab/nsp4449N449SaAtaGt22AY.250.000012
ORF1ab/nsp4449N449NaaTaaC22AY.260.000057
ORF1ab/nsp4449N449NaaTaaC22AY.360.000296
ORF1ab/nsp4449N449delAAT---22AY.40.000003
ORF1ab/nsp4449N449NaaTaaC22AY.4.20.000043
ORF1ab/nsp4449N449delAAT---22AY.430.000009
ORF1ab/nsp4449N449NaaTaaC22AY.450.000243
ORF1ab/nsp4449N449delAAT---22AY.520.001629
ORF1ab/nsp4449N449NaaTaaC22AY.680.000547
ORF1ab/nsp4449N449NaaTaaC22AY.7.10.000225
ORF1ab/nsp4449N449NaaTaaC22B.1.1.2690.002706
ORF1ab/nsp4449N449delAAT---22B.1.1.4090.005666
ORF1ab/nsp4449N449IaAtaTt22B.1.1.70.000002
ORF1ab/nsp4449N449YAatTat22B.1.1.70.000002
ORF1ab/nsp4449N449delAAT---22B.1.177.40.000422
ORF1ab/nsp4449N449SaAtaGt22B.1.617.20.000008
ORF1ab/nsp4449N449YAatTat22P.1.10.000635
ORF1ab/nsp4449N449TaAtaCt22P.1.170.000324
ORF1ab/nsp4449N449YAatTat11A0.000387
ORF1ab/nsp4449N449delAAT---11A.210.00277
ORF1ab/nsp4449N449GAAtGGt11All0
ORF1ab/nsp4449N449FAAtTTt11All0
ORF1ab/nsp4449N449CAATTGC11All0
ORF1ab/nsp4449N449delAAT---11AY.1000.000046
ORF1ab/nsp4449N449NaaTaaC11AY.1050.000643
ORF1ab/nsp4449N449delAAT---11AY.1080.001103
ORF1ab/nsp4449N449SaAtaGt11AY.1100.000113
ORF1ab/nsp4449N449NaaTaaC11AY.1170.000085
ORF1ab/nsp4449N449NaaTaaC11AY.1180.000063
ORF1ab/nsp4449N449SaAtaGt11AY.1200.000037
ORF1ab/nsp4449N449delAAT---11AY.190.00114
ORF1ab/nsp4449N449NaaTaaC11AY.200.000039
ORF1ab/nsp4449N449KaaTaaA11AY.250.000006
ORF1ab/nsp4449N449delAAT---11AY.250.000006
ORF1ab/nsp4449N449delAAT---11AY.260.000028
ORF1ab/nsp4449N449NaaTaaC11AY.270.000065
ORF1ab/nsp4449N449NaaTaaC11AY.29.10.000221
ORF1ab/nsp4449N449delAAT---11AY.30.00001
ORF1ab/nsp4449N449NaaTaaC11AY.330.000067
ORF1ab/nsp4449N449TaATaCC11AY.390.000025
ORF1ab/nsp4449N449SaAtaGt11AY.39.10.00004
ORF1ab/nsp4449N449YAatTat11AY.40.000002
ORF1ab/nsp4449N449SaAtaGt11AY.4.20.000022
ORF1ab/nsp4449N449del1Aat-at11AY.4.2.10.000149
ORF1ab/nsp4449N449delAAT---11AY.4.2.10.000149
ORF1ab/nsp4449N449SaAtaGt11AY.430.000004
ORF1ab/nsp4449N449DAatGat11AY.440.000006
ORF1ab/nsp4449N449SaAtaGt11AY.460.000104
ORF1ab/nsp4449N449NaaTaaC11AY.46.20.000635
ORF1ab/nsp4449N449NaaTaaC11AY.46.60.000072
ORF1ab/nsp4449N449NaaTaaC11AY.470.000031
ORF1ab/nsp4449N449NaaTaaC11AY.50.000021
ORF1ab/nsp4449N449delAAT---11AY.60.000041
ORF1ab/nsp4449N449delAAT---11AY.620.000436
ORF1ab/nsp4449N449NaaTaaC11AY.740.000116
ORF1ab/nsp4449N449NaaTaaC11AY.840.000437
ORF1ab/nsp4449N449KaaTaaA11AY.870.000833
ORF1ab/nsp4449N449NaaTaaC11AY.870.000833
ORF1ab/nsp4449N449SaAtaGt11AY.9.20.000037
ORF1ab/nsp4449N449delAAT---11AY.9.20.000037
ORF1ab/nsp4449N449NaaTaaC11AY.920.000287
ORF1ab/nsp4449N449KaaTaaA11AY.930.000273
ORF1ab/nsp4449N449NaaTaaC11AY.990.001049
ORF1ab/nsp4449N449FAAtTTt11B.10.000009
ORF1ab/nsp4449N449KaaTaaG11B.10.000009
ORF1ab/nsp4449N449del1Aat-at11B.10.000009
ORF1ab/nsp4449N449IaAtaTt11B.10.000009
ORF1ab/nsp4449N449DAatGat11B.10.000009
ORF1ab/nsp4449N449IaAtaTt11B.1.10.000018
ORF1ab/nsp4449N449delAAT---11B.1.1.1390.022727
ORF1ab/nsp4449N449TaAtaCt11B.1.1.1920.002309
ORF1ab/nsp4449N449NaaTaaC11B.1.1.2140.000055
ORF1ab/nsp4449N449IaAtaTt11B.1.1.250.000569
ORF1ab/nsp4449N449TaAtaCt11B.1.1.3090.005848
ORF1ab/nsp4449N449NaaTaaC11B.1.1.3170.000412
ORF1ab/nsp4449N449delAAT---11B.1.1.3480.000796
ORF1ab/nsp4449N449NaaTaaC11B.1.1.3700.012658
ORF1ab/nsp4449N449delAAT---11B.1.1.5280.004808
ORF1ab/nsp4449N449del2aATa--11B.1.1.70.000001
ORF1ab/nsp4449N449CAATTGC11B.1.1.70.000001
ORF1ab/nsp4449N449SaAtaGt11B.1.1.70.000001
ORF1ab/nsp4449N449del1aaTaa-11B.1.1.70.000001
ORF1ab/nsp4449N449TaAtaCt11B.1.1.70.000001
ORF1ab/nsp4449N449NaaTaaC11B.1.130.002375
ORF1ab/nsp4449N449YAatTat11B.1.1390.000733
ORF1ab/nsp4449N449SaAtaGt11B.1.1770.000013
ORF1ab/nsp4449N449DAatGat11B.1.1770.000013
ORF1ab/nsp4449N449del2AAt--t11B.1.1770.000013
ORF1ab/nsp4449N449GAAtGGt11B.1.1770.000013
ORF1ab/nsp4449N449del1Aat-at11B.1.1770.000013
ORF1ab/nsp4449N449delAAT---11B.1.177.150.000631
ORF1ab/nsp4449N449delAAT---11B.1.177.160.000664
ORF1ab/nsp4449N449delAAT---11B.1.177.540.000606
ORF1ab/nsp4449N449SaAtaGt11B.1.177.70.000165
ORF1ab/nsp4449N449NaaTaaC11B.1.177.760.002494
ORF1ab/nsp4449N449NaaTaaC11B.1.177.80.000752
ORF1ab/nsp4449N449NaaTaaC11B.1.177.810.000189
ORF1ab/nsp4449N449delAAT---11B.1.177.810.000189
ORF1ab/nsp4449N449delAAT---11B.1.1790.003759
ORF1ab/nsp4449N449del1Aat-at11B.1.20.000009
ORF1ab/nsp4449N449delAAT---11B.1.258.30.001675
ORF1ab/nsp4449N449IaAtaTt11B.1.351.30.000876
ORF1ab/nsp4449N449delAAT---11B.1.360.000146
ORF1ab/nsp4449N449YAatTat11B.1.36.160.001425
ORF1ab/nsp4449N449delAAT---11B.1.4290.000024
ORF1ab/nsp4449N449IaAtaTt11B.1.4460.02
ORF1ab/nsp4449N449delAAT---11B.1.4560.003268
ORF1ab/nsp4449N449IaAtaTt11B.1.4650.003802
ORF1ab/nsp4449N449NaaTaaC11B.1.466.20.000391
ORF1ab/nsp4449N449YAatTat11B.1.5760.000907
ORF1ab/nsp4449N449SaAtaGt11B.1.5960.000087
ORF1ab/nsp4449N449NaaTaaC11B.1.617.10.000129
ORF1ab/nsp4449N449YAatTat11B.1.617.20.000004
ORF1ab/nsp4449N449TaAtaCt11B.1.617.20.000004
ORF1ab/nsp4449N449SaAtaGt11B.1.6360.006711
ORF1ab/nsp4449N449TaAtaCt11C.140.004329
ORF1ab/nsp4449N449KaaTaaG11C.350.000774
ORF1ab/nsp4449N449SaAtaGt11C.370.000116
ORF1ab/nsp4449N449SaAtaGt11C.380.008065
ORF1ab/nsp4449N449IaAtaTt11D.20.000075
ORF1ab/nsp4449N449SAAtTCt11P.1.10.000318
ORF1ab/nsp4449N449delAAT---11P.1.10.10.00813
ORF1ab/nsp4449N449DAatGat11P.1.120.000484
ORF1ab/nsp4449N449NaaTaaC11P.1.120.000484
ORF1ab/nsp4449N449delAAT---11P.1.150.000232
ORF1ab/nsp4449N449delAAT---11Q.10.000126
ORF1ab/nsp4449N449NaaTaaC11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.